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General Information
Symbol
Dmel\Sac1L2F
Species
D. melanogaster
Name
FlyBase ID
FBal0141545
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G1249603A

Amino acid change:

W438term | Sac1-PA; W438term | Sac1-PB

Reported amino acid change:

W438term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W438term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous embryos have dorsal anterior holes in the cuticle. They also show puckering of the dorsal cuticle and an absence of dorsal hairs along the midline. Homozygous and Sac1L2F/Df(3L)Fpa2 embryos show apical constriction of the middle amnioserosa cells at the onset of dorsal closure (in wild-type embryos, the middle amnioserosa cells are the last to show apical constriction during dorsal closure). Sac1BG02228/Sac1L2F and Sac1L2F/Df(3L)B67 embryos have dorsal anterior holes in the cuticle and puckering of the dorsal cuticle. Heterozygous embryos do not show cuticle defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

The frequency of dorsal holes in the cuticle seen in bsk1 embryos is partially suppressed by Sac1L2F/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Sac1L2F
l(3)2107L2F
Name Synonyms
Secondary FlyBase IDs
    References (3)