PI4P phosphatase, lipid phosphatase - promotes microtubule stability in the developing retina, regulates postembryonic synaptic maturation and neurodegeneration - binding partner of VAMP-associated protein 33kDa (Vap33 or DVap) - Drosophila model of amyotrophic lateral sclerosis, functions downstream of STT4 and Ptc in the regulation of Smo membrane localization and Hh pathway activation - dorsal closure - axonal transport - microtubule stability
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sac1 using the Feature Mapper tool.
Sac1 is highly expressed during early stages of embryogenesis and is most prominent in the pole cells. At embryonic stage 13 and 16, expression is mostly restricted to the developing central and peripheral nervous systems. Expression is also observed in the dorsal epidermis around the amnioserosa at stage 13. Sac1 expression at stage 16 completely overlaps the 22C10 antibody pattern in the PNS showing strong expression in all sensory neurons. In the CNS, Sac1 is expressed in a subset of longitudinal fascicles.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Sac1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
A weak Sac1 allele causes defects in eye development, while stronger alleles die as embryos with defects in head involution and dorsal closure.
Mutants die as embryos with defects in dorsal closure.