FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sac11
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General Information
Symbol
Dmel\Sac11
Species
D. melanogaster
Name
FlyBase ID
FBal0266063
Feature type
allele
Associated gene
Dmel\Sac1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lee et al., 2011)
Progenitor genotype
P{EP}Sac1G8721
(Lee et al., 2011)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 2222bp deletion that extends from -17 to +2205 relative to the Sac1 translation start site.

(Lee et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:1,248,274..1,250,495 [+]
Comment:

2222 bp deletion, resulting from the imprecise excision of P{EP}Sac1G8721 removes the Sac1 coding sequence.

(Lee et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Central nervous system axons are often seen ectopically crossing the midline in Sac11/Sac12 and Sac11/Sac12107 embryos.

      (Lee et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      robo2/+ Sac11/+ and sli2/+ Sac11/+ double heterozygotes show a high frequency of ectopic midline crossings in the central nervous system.

      (Lee et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Sac11/Sac12 is partially rescued by Scer\GAL4elav-C155/Sac1UAS.WT.Tag:HA

      (Lee et al., 2011)

      Sac11/Sac12 is partially rescued by Scer\GAL4da.G32/Sac1UAS.WT.Tag:HA

      (Lee et al., 2011)
      Not rescued by

      Sac11/Sac12 is not rescued by Scer\GAL4elav-C155/Sac1UAS.CS-TA.Tag:HA

      (Lee et al., 2011)

      Sac11/Sac12 is not rescued by Scer\GAL4da.G32/Sac1UAS.CS-TA.Tag:HA

      (Lee et al., 2011)
      Comments

      Expression of Sac1Scer\UAS.WT.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 substantially rescues the ectopic midline crossing phenotype seen in Sac11/Sac12 embryos.

      Expression of Sac1Scer\UAS.WT.T:Ivir\HA1 under the control of Scer\GAL4da.G32 substantially rescues the lethality of Sac11/Sac12 animals.

      Expression of Sac1Scer\UAS.CS-TA.T:Ivir\HA1 under the control of Scer\GAL4elav-C155 fails to rescue the ectopic midline crossing phenotype seen in Sac11/Sac12 embryos.

      Expression of Sac1Scer\UAS.CS-TA.T:Ivir\HA1 under the control of Scer\GAL4da.G32 fails to rescue the lethality of Sac11/Sac12 animals.

      (Lee et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sac11
      sac11
      (Lee et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)