FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Synj
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General Information
Symbol
Dmel\Synj
Species
D. melanogaster
Name
Synaptojanin
Annotation Symbol
CG6562
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034691
Gene Model Status
Current
Stock Availability
18 publicly available
Enzyme Name (EC)
phosphoinositide 5-phosphatase (3.1.3.36)
phosphatidylinositol-3-phosphatase (3.1.3.64)
Gene Summary
Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
58B4-58B4
Sequence location
Recombination map
2-98
RefSeq locus
NT_033778 REGION:22080176..22085767
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (22 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
enables inositol-1,4,5-trisphosphate 5-phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN002597976
(GO Reference Genome Project, 2011-)
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR035979
(InterPro Project Members, 2004-)
enables phosphatase activity
inferred from electronic annotation with InterPro:IPR000300, InterPro:IPR002013
(InterPro Project Members, 2004-)
enables phosphatidylinositol phosphate 5-phosphatase activity
inferred from sequence or structural similarity with UniProtKB:Q62910
(Gene Ontology Curators, 2002-)
enables phosphatidylinositol-3-phosphate phosphatase activity
inferred from sequence or structural similarity with UniProtKB:O43426
(Gene Ontology Curators, 2002-)
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN008514002
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:O43426
(Gene Ontology Curators, 2002-)
enables phosphatidylinositol-4-phosphate phosphatase activity
inferred from sequence or structural similarity with UniProtKB:O43426
(Gene Ontology Curators, 2002-)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in bulk synaptic vesicle endocytosis
inferred from mutant phenotype
(Verstreken et al., 2003)
involved_in clathrin-dependent synaptic vesicle endocytosis
inferred from mutant phenotype
(Verstreken et al., 2003)
involved_in maintenance of presynaptic active zone structure
inferred from mutant phenotype
(Dickman et al., 2006)
involved_in negative regulation of smoothened signaling pathway
inferred from mutant phenotype
(Ahaley, 2018)
involved_in positive regulation of autophagosome assembly
inferred from mutant phenotype
(Vanhauwaert et al., 2017)
involved_in regulation of synapse structure or activity
inferred from mutant phenotype
(Dickman et al., 2006)
involved_in synaptic vesicle endocytosis
inferred from mutant phenotype
(Dickman et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in phosphatidylinositol dephosphorylation
inferred from electronic annotation with InterPro:IPR000300, InterPro:IPR046985
(InterPro Project Members, 2004-)
involved_in synaptic vesicle endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000878538
(GO Reference Genome Project, 2011-)
Cellular Component (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Vanhauwaert et al., 2017)
located_in autophagosome
inferred from direct assay
(Vanhauwaert et al., 2017)
located_in terminal bouton
inferred from direct assay
(Verstreken et al., 2003)
located_in type I terminal bouton
inferred from direct assay
(Vanhauwaert et al., 2017)
located_in vesicle membrane
inferred from direct assay
(Verstreken et al., 2003)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000127779
(GO Reference Genome Project, 2011-)
is_active_in membrane
inferred from biological aspect of ancestor with PANTHER:PTN000127779
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
inositol-1,4,5-trisphosphate 5-phosphatase activity
RHEA 19797: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate (3.1.3.36)
RHEA 22764: phosphatidylinositol-3-phosphate phosphatase activity
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate (3.1.3.64)
RHEA 12316: phosphatidylinositol-4-phosphate phosphatase activity
RHEA 55652:
Summaries
Gene Snapshot
Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES -
Phosphoinositide phosphate (PtdInsP) phosphatases and Inositol phosphate (InsP) phosphatases are enzymes that catalyze the hydrolysis of phosphate groups from inositol. Many of these phosphatases can act on both PtdInsP and InsP substrates. (Adapted from PMID:23681533).
Pathway (FlyBase)
NEGATIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Synj for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q5U0V7)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.51

Gene model reviewed during 6.19

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Synj-RA
FBtr0071757
NM_166505
4409
1218
Synj-RB
FBtr0071756
NM_130462
4243
1218
Synj-RC
FBtr0308239
NM_001259525
4638
1218
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Synj-PA
FBpp0071671
134.6
1218
6.99
Q5U0V7
NP_726155
AAF46796
Synj-PB
FBpp0071670
134.6
1218
6.99
Q5U0V7
NP_569729
AAG22194
Synj-PC
FBpp0300559
134.6
1218
6.99
Q5U0V7
NP_001246454
AFH08207
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1218 aa isoforms: Synj-PA, Synj-PB, Synj-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Synj using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.27

Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism

Comment: expressed at low levels

(Verstreken et al., 2003)
larval stage
organism

Comment: expressed at high levels

(Verstreken et al., 2003)
adult stage
organism

Comment: expressed at high levels

(Verstreken et al., 2003)
Additional Descriptive Data

expressed at high levels during larvae and adults, at low levels in embryos, and not at all in pupae.

(Verstreken et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
cell fractionation
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Verstreken et al., 2003)
immunohistochemistry
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
NMJ bouton
(Verstreken et al., 2003)
adult stage
optic cartridge
(Verstreken et al., 2003)
outer photoreceptor cell
(Verstreken et al., 2003)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in autolysosome
inferred from direct assay
(Vanhauwaert et al., 2017)
located_in autophagosome
inferred from direct assay
(Vanhauwaert et al., 2017)
located_in terminal bouton
inferred from direct assay
(Verstreken et al., 2003)
located_in type I terminal bouton
inferred from direct assay
(Vanhauwaert et al., 2017)
located_in vesicle membrane
inferred from direct assay
(Verstreken et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Synj in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 14 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Synj
Transgenic constructs containing regulatory region of Synj
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
lethal - all die before end of larval stage (with Synj1)
lethal - all die before end of larval stage (with Synj2)
partially lethal - majority die (with Synj1)
partially lethal - majority die (with Synj2)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal chemosensory behavior | adult stage
abnormal locomotor behavior | larval stage | recessive
abnormal neuroanatomy (with Df(2R)X58-7)
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | somatic clone
abnormal neurophysiology (with Df(2R)R1-8)
abnormal neurophysiology (with Df(2R)X58-7)
abnormal neurophysiology (with Synj1)
abnormal neurophysiology (with Synj2)
abnormal neurophysiology | adult stage | somatic clone
abnormal neurophysiology | larval stage
abnormal neurophysiology | somatic clone
abnormal neurophysiology | third instar larval stage (with Synj1)
abnormal neurophysiology | third instar larval stage (with Synj2)
decreased cell number | adult stage
decreased rate of adult locomotory behavior | progressive
increased size | adult stage
short lived | nutrition conditional
short lived | nutrition conditional, with Scer\GAL4Toll-6-D42, Synj2/Synj1
short lived | nutrition conditional (with Synj1), with Scer\GAL4Toll-6-D42, SynjRQ.UAS
short lived | nutrition conditional (with Synj2), with Scer\GAL4Toll-6-D42, SynjRQ.UAS
Phenotype manifest in
Allele
adult dopaminergic neuron
adult mushroom body
adult olfactory projection neuron
autolysosome | third instar larval stage | nutrition conditional (with Synj1)
autolysosome | third instar larval stage | nutrition conditional (with Synj2)
autophagosome | third instar larval stage | conditional, with Scer\GAL4Toll-6-D42, Synj2/Synj1
autophagosome | third instar larval stage | conditional (with Synj1), with Scer\GAL4Toll-6-D42, SynjRQ.UAS
autophagosome | third instar larval stage | conditional (with Synj2), with Scer\GAL4Toll-6-D42, SynjRQ.UAS
autophagosome | third instar larval stage | nutrition conditional, with Scer\GAL4Toll-6-D42, Synj2/Synj1
autophagosome | third instar larval stage | nutrition conditional (with Synj1)
autophagosome | third instar larval stage | nutrition conditional (with Synj1), with Scer\GAL4Toll-6-D42, SynjRQ.UAS
autophagosome | third instar larval stage | nutrition conditional (with Synj2)
autophagosome | third instar larval stage | nutrition conditional (with Synj2), with Scer\GAL4Toll-6-D42, SynjRQ.UAS
bouton | larval stage
dense body | increased number (with Df(2R)X58-7)
dopaminergic PPL1 neuron | adult stage
dopaminergic PPM3 neuron | adult stage
eye | somatic clone
mitochondrial membrane | larval stage
neuromuscular junction & synaptic vesicle (with Df(2R)X58-7)
neuromuscular junction | third instar larval stage
neuromuscular junction | third instar larval stage (with Synj1)
neuromuscular junction | third instar larval stage (with Synj2)
neuromuscular junction | third instar larval stage | nutrition conditional
neuromuscular junction | third instar larval stage | nutrition conditional (with Synj1)
neuromuscular junction | third instar larval stage | nutrition conditional (with Synj2)
NMJ bouton | increased number (with Df(2R)X58-7)
NMJ bouton | larval stage
NMJ bouton | third instar larval stage (with Synj1)
NMJ bouton | third instar larval stage (with Synj2)
ommatidium | adult stage, with Scer\GAL4nSyb.PU, Synj2/Synj1
ommatidium | adult stage (with Synj1), with Scer\GAL4nSyb.PU, SynjRQ.UAS
ommatidium | adult stage (with Synj2), with Scer\GAL4nSyb.PU, SynjRQ.UAS
photoreceptor & synaptic vesicle
presynaptic active zone (with Df(2R)X58-7)
retina | adult stage | somatic clone
retina | somatic clone
synaptic vesicle | somatic clone
synaptic vesicle | third instar larval stage | nutrition conditional
synaptic vesicle | third instar larval stage | nutrition conditional (with Synj1)
synaptic vesicle | third instar larval stage | nutrition conditional (with Synj2)
type I terminal bouton | third instar larval stage (with Synj1)
type I terminal bouton | third instar larval stage (with Synj2)
vesicle | third instar larval stage (with Synj1)
vesicle | third instar larval stage (with Synj2)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (15)
Hsap\SYNJ1
14 of 14
Yes
Yes
Hsap\SYNJ2
10 of 14
No
Yes
Hsap\INPP5D
3 of 14
No
Yes
1  
Hsap\INPP5F
3 of 14
No
No
Hsap\INPP5J
3 of 14
No
No
Hsap\INPP5K
3 of 14
No
No
1  
Hsap\INPPL1
3 of 14
No
Yes
Hsap\OCRL
3 of 14
No
No
Hsap\FIG4
2 of 14
No
No
Hsap\INPP5B
2 of 14
No
No
1  
Hsap\INPP5E
2 of 14
No
No
1  
Hsap\SACM1L
2 of 14
No
No
Hsap\SH2D1A
2 of 14
No
Yes
Hsap\SH2D1B
2 of 14
No
Yes
1  
Hsap\INPP5A
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (15)
Rnor\Synj1
13 of 14
Yes
Yes
Rnor\Synj2
10 of 14
No
Yes
Rnor\Inpp5d
3 of 14
No
Yes
Rnor\Inpp5f
3 of 14
No
No
Rnor\Inpp5j
3 of 14
No
No
Rnor\Inppl1
3 of 14
No
Yes
Rnor\Fig4
2 of 14
No
No
Rnor\Inpp5b
2 of 14
No
No
Rnor\Inpp5k
2 of 14
No
No
Rnor\Ocrl
2 of 14
No
No
Rnor\Sacm1l
2 of 14
No
No
Rnor\Sh2d1a
2 of 14
No
Yes
Rnor\Sh2d1b2
2 of 14
No
Yes
Rnor\Sh2d1b
2 of 14
No
Yes
Rnor\Inpp5e
1 of 14
No
No
Mus musculus (laboratory mouse) (15)
Mmus\Synj1
14 of 14
Yes
Yes
Mmus\Synj2
10 of 14
No
Yes
Mmus\Inpp5d
3 of 14
No
Yes
Mmus\Inpp5j
3 of 14
No
No
Mmus\Inpp5k
3 of 14
No
No
Mmus\Inppl1
3 of 14
No
Yes
Mmus\Ocrl
3 of 14
No
No
Mmus\Fig4
2 of 14
No
No
Mmus\Inpp5b
2 of 14
No
No
Mmus\Inpp5e
2 of 14
No
No
Mmus\Inpp5f
2 of 14
No
No
Mmus\Sacm1l
2 of 14
No
No
Mmus\Sh2d1a
2 of 14
No
Yes
Mmus\Sh2d1b2
2 of 14
No
Yes
Mmus\Sh2d1b1
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (14)
Xtro\synj1
11 of 13
Yes
Yes
Xtro\synj2
8 of 13
No
Yes
Xtro\acss2.1
1 of 13
No
No
Xtro\emilin2
1 of 13
No
No
Xtro\fig4
1 of 13
No
No
Xtro\inpp5f
1 of 13
No
No
Xtro\LOC116409534
1 of 13
No
No
Xtro\mak
1 of 13
No
No
Xtro\nfyc
1 of 13
No
No
Xtro\sacm1l
1 of 13
No
No
Xtro\sipa1l3
1 of 13
No
No
Xtro\sulf2
1 of 13
No
No
Xtro\trappc9
1 of 13
No
No
Xtro\vrk1
1 of 13
No
No
Danio rerio (Zebrafish) (19)
Drer\synj1
13 of 14
Yes
Yes
Drer\inpp5f
3 of 14
No
No
Drer\inpp5jb
3 of 14
No
No
Drer\ocrl
3 of 14
No
No
Drer\fig4a
2 of 14
No
No
Drer\inpp5d
2 of 14
No
Yes
Drer\inpp5ka
2 of 14
No
No
Drer\inpp5kb
2 of 14
No
No
Drer\inppl1a
2 of 14
No
Yes
Drer\inppl1b
2 of 14
No
Yes
Drer\sacm1la
2 of 14
No
No
Drer\sacm1lb
2 of 14
No
No
Drer\sh2d1aa
2 of 14
No
Yes
Drer\sh2d1ab
2 of 14
No
Yes
Drer\si:ch73-264p11.1
2 of 14
No
Yes
Drer\fig4b
1 of 14
No
Yes
Drer\inpp5b
1 of 14
No
No
Drer\inpp5e
1 of 14
No
No
Drer\LOC569568
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\unc-26
13 of 14
Yes
Yes
Cele\cil-1
2 of 14
No
No
Cele\figo-1
2 of 14
No
No
Cele\sac-1
2 of 14
No
No
Cele\sac-2
2 of 14
No
No
Cele\inpp-1
1 of 14
No
No
Cele\ocrl-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP012175
12 of 12
Yes
Yes
Agam\AgaP_AGAP000483
2 of 12
No
No
Agam\AgaP_AGAP000891
2 of 12
No
No
Agam\AgaP_AGAP004477
2 of 12
No
No
Agam\AgaP_AGAP005139
2 of 12
No
No
Agam\AgaP_AGAP010556
2 of 12
No
No
Agam\AgaP_AGAP011644
2 of 12
No
No
Agam\AgaP_AGAP000203
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (24)
Atha\AT2G37440
3 of 13
Yes
No
Atha\AT3G63240
3 of 13
Yes
No
Atha\BST1
3 of 13
Yes
No
Atha\CVL1
3 of 13
Yes
No
Atha\CVP2
3 of 13
Yes
No
Atha\5PTASE11
2 of 13
No
No
Atha\5PTase12
2 of 13
No
No
Atha\5PTASE13
2 of 13
No
No
Atha\5PTase14
2 of 13
No
No
Atha\AT1G17340
2 of 13
No
No
Atha\AT1G71710
2 of 13
No
No
Atha\AT2G01900
2 of 13
No
No
Atha\AT3G14205
2 of 13
No
No
Atha\AT3G43220
2 of 13
No
No
Atha\AT5G04980
2 of 13
No
No
Atha\AT5G20840
2 of 13
No
No
Atha\ATSAC1B
2 of 13
No
No
Atha\FRA3
2 of 13
No
No
Atha\IP5PI
2 of 13
No
No
Atha\IP5PII
2 of 13
No
No
Atha\RHD4
2 of 13
No
No
Atha\SAC8
2 of 13
No
No
Atha\SAC9
2 of 13
No
No
Atha\ATSAC1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (6)
Scer\INP52
11 of 13
Yes
Yes
Scer\INP53
11 of 13
Yes
Yes
Scer\INP51
6 of 13
No
Yes
Scer\INP54
2 of 13
No
No
Scer\FIG4
1 of 13
No
No
Scer\SAC1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\syj1
10 of 12
Yes
Yes
Spom\syj2
4 of 12
No
Yes
Spom\SPAC9G1.10c
2 of 12
No
No
Spom\SPAC3C7.01c
1 of 12
No
No
Spom\SPAC1093.03
1 of 12
No
No
Spom\SPBC19F5.03
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Synj. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
CG6805
4 of 13
CG9784
4 of 13
Ocrl
4 of 13
FIG4
3 of 13
INPP5E
3 of 13
Sac1
3 of 13
sp3
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SYNJ1; synaptojanin 1
14 of 14
604297
SYNJ2; synaptojanin 2
10 of 14
609410
      INPP5D; inositol polyphosphate-5-phosphatase D
      3 of 14
      601582
           
          INPP5F; inositol polyphosphate-5-phosphatase F
          3 of 14
          609389
              INPP5J; inositol polyphosphate-5-phosphatase J
              3 of 14
              606481
                  INPP5K; inositol polyphosphate-5-phosphatase K
                  3 of 14
                  607875
                   
                  INPPL1; inositol polyphosphate phosphatase like 1
                  3 of 14
                  600829
                    OCRL; OCRL inositol polyphosphate-5-phosphatase
                    3 of 14
                    300535
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Synj
                    enhanceable
                    EndoA
                    (Verstreken et al., 2003)
                    Synj
                    suppressible
                    EndoA
                    (Verstreken et al., 2003)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    mnb
                    suppressible
                    Synj
                    (Chen et al., 2014)
                    shi
                    enhanceable
                    Synj
                    (Dickman et al., 2005)
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                    KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                    External Data
                    Linkouts
                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2R
                    Recombination map
                    2-98
                    Cytogenetic map
                    58B4-58B4
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    58B4-58B4
                    Limits computationally determined from genome sequence between P{EP}CG6393EP2457 and P{PZ}ari-207768
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    58A-58B
                    (Lloyd et al., 2000)
                    Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
                    (Lloyd et al., 2000)
                    Experimentally Determined Recombination Data
                    Location

                    2-98

                    (FlyBase, 2016)

                    2-103.6

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (18)
                    Genomic Clones (17)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (18)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Geng et al., 2016, Chen et al., 2014, Verstreken et al., 2003)
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                          (Kiger et al., 2003)
                          Relationship to Other Genes
                          Source for database merge of
                          Additional comments
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: synaptojanin CG6562

                          (Verstreken and Bellen, 2000.9.4)

                          Source for identity of: Synj synj

                          (FlyBase, 2009-)
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (7)
                          Reported As
                          Symbol Synonym
                          CG6562
                          (National Institute of Genetics Fly Stocks, 2022-, Allen et al., 2020, Trivedi et al., 2020, Jouette et al., 2017, Meadows, 2017.9.14, Balakrishnan et al., 2015, Hosono et al., 2015, Ni et al., 2010.12.1, Perkins et al., 2009, Seeds et al., 2004, Morrison et al., 2000)
                          IPP
                          (Morrison et al., 2000)
                          Synj
                          (Pech et al., 2025, Bilder et al., 2021, Lasko and Lüthy, 2021, Ostalé et al., 2021, Pang et al., 2021, Allen et al., 2020, Takai et al., 2020, Arbones et al., 2019, Aryal and Lee, 2019, Ahaley, 2018, Gene Disruption Project members, 2018-, Jouette et al., 2017, Song et al., 2017, Transgenic RNAi Project members, 2017-, Androschuk et al., 2015, Vanhauwaert and Verstreken, 2015, Massarwa et al., 2007, Koh et al., 2004)
                          synj
                          (Lu et al., 2022, Peng et al., 2021, Li et al., 2020, Vanhauwaert et al., 2017, Fischer et al., 2016, Geng et al., 2016, Balakrishnan et al., 2015, Di Cara et al., 2015, Huang et al., 2015, Chen et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Petersen and Stowers, 2011, Khuong et al., 2010, Chang and Min, 2009, Compagnon et al., 2009, Dickman and Davis, 2009, Venken et al., 2009, Venken et al., 2009, Verstreken et al., 2009, Kasprowicz et al., 2008, Venken et al., 2008, Korolchuk et al., 2007, Dickman, 2006, Hiesinger et al., 2006, Dickman et al., 2005)
                          Name Synonyms
                          Synaptojanin
                          (Tsai et al., 2017, Chen et al., 2014, Font-Burgada et al., 2008, Venken et al., 2008, Roos and Kelly, 1998)
                          synaptojanin
                          (Li et al., 2020, Latcheva et al., 2019, Fischer et al., 2016, Bothe et al., 2014, Petersen and Stowers, 2011, Khuong et al., 2010, Chang and Min, 2009, Verstreken et al., 2009, Habets et al., 2008, Kasprowicz et al., 2008, Venken et al., 2008, Dickman et al., 2006)
                          synaptojanin-1
                          (Ciampelli et al., 2025)
                          Secondary FlyBase IDs
                            Datasets (0)
                            Study focus (0)
                            Experimental Role
                            Project
                            Project Type
                            Title
                            Study result (0)
                            Result
                            Result Type
                            Title
                            External Crossreferences and Linkouts ( 67 )
                            Sequence Crossreferences
                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                            Other crossreferences
                            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                            FlyMine - An integrated database for Drosophila genomics
                            InterPro - A database of protein families, domains and functional sites
                            KEGG Genes - Molecular building blocks of life in the genomic space.
                            MARRVEL_MODEL - MARRVEL (model organism gene)
                            Linkouts
                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                            DroID - A comprehensive database of gene and protein interactions.
                            DRSC - Results frm RNAi screens
                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                            FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                            Flygut - An atlas of the Drosophila adult midgut
                            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                            KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                            MIST (genetic) - An integrated Molecular Interaction Database
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                            References (113)