FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term inositol-1,4,5-trisphosphate 5-phosphatase activity ID (Ontology) GO:0052658 (Gene Ontology)
Definition Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 inositol-1,4,5-trisphosphate 5-phosphatase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | inositol-1,4,5-trisphosphate 5-phosphatase activity
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  inositol trisphosphate phosphatase activity
   |__inositol-polyphosphate 5-phosphatase activity
       |__inositol-1,4,5-trisphosphate 5-phosphatase activity  1 rec.
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Is a inositol-polyphosphate 5-phosphatase activity
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Synonyms
  • "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" RELATED[ EC:3 ]
    "5PTase activity" RELATED[ EC:3 ]
    "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" RELATED[ EC:3 ]
    "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" RELATED[ EC:3 ]
    "D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity" RELATED[ EC:3 ]
    "inosine triphosphatase activity" RELATED[ EC:3 ]
    "inositol 1,4,5-trisphosphate phosphatase activity" BROAD[ EC:3 ]
    "inositol phosphate 5-phosphomonoesterase activity" BROAD[ EC:3 ]
    "inositol polyphosphate-5-phosphatase activity" BROAD[ EC:3 ]
    "Ins(1,4,5)P3 5-phosphatase activity" RELATED[ EC:3 ]
    "InsP(3) 5-phosphatase activity" BROAD[ EC:3 ]
    "InsP3 5-phosphatase activity" BROAD[ EC:3 ]
    "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD[ EC:3 ]
    "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" RELATED[ EC:3 ]
    "type I inositol-polyphosphate phosphatase activity" RELATED[ EC:3 ]
    "type II inositol polyphosphate 5-phosphatase activity" RELATED
Secondary IDs
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KEGG_REACTION:R03394
MetaCyc:3.1.3.56-RXN
Reactome:R-HSA-1855174 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol"
Reactome:R-HSA-1855222 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane"
RHEA:19797