FlyBase Gene Report: Dmel\EndoA

General Information

Symbol

Dmel\EndoA

Species

D. melanogaster

Name

Endophilin A

Annotation Symbol

CG14296

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038659

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Endophilin A (EndoA) encodes an essential protein for synaptic vesicle endocytosis. It recruits or stabilizes the product of Synj (required for vesicle uncoating) to endocytic membranes. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

endophilin, endo

Key Links

Genomic Location

Cytogenetic map

91D4-91D4

Sequence location

3R:18,906,609..18,911,117 [+]

Recombination map

3-65

RefSeq locus

NT_033777 REGION:18906609..18911117

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables phospholipid binding

inferred from direct assay

(Soukup et al., 2016, Matta et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables protein-macromolecule adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN009017043

(GO Reference Genome Project, 2011-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (9 terms)

CV Term

Evidence

References

involved_in autophagosome assembly

inferred from mutant phenotype

(Soukup et al., 2016)

involved_in cellular response to starvation

inferred from mutant phenotype

(Soukup et al., 2016)

inferred from genetic interaction with FLYBASE:Lrrk; FB:FBgn0038816

(Soukup et al., 2016)

involved_in clathrin-dependent synaptic vesicle endocytosis

inferred from mutant phenotype

(Guichet et al., 2002, Verstreken et al., 2002)

involved_in endocytosis

inferred from mutant phenotype

(Soukup et al., 2016)

involved_in membrane bending

inferred from direct assay

(Soukup et al., 2016)

involved_in membrane tubulation

inferred from direct assay

(Soukup et al., 2016)

involved_in plasma membrane tubulation

inferred from direct assay

(Matta et al., 2012)

involved_in regulation of synapse structure or activity

inferred from mutant phenotype

(Dickman et al., 2006, Rikhy et al., 2002)

involved_in synaptic vesicle endocytosis

inferred from mutant phenotype

(Matta et al., 2012, Dickman et al., 2005, Fabian-Fine et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in endocytosis

inferred from biological aspect of ancestor with PANTHER:PTN009017136

(GO Reference Genome Project, 2011-)

involved_in membrane organization

inferred from biological aspect of ancestor with PANTHER:PTN009017136

(GO Reference Genome Project, 2011-)

involved_in synaptic vesicle endocytosis

traceable author statement

(Kjaerulff et al., 2002)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Matta et al., 2012, Guichet et al., 2002)

located_in membrane

inferred from direct assay

(Matta et al., 2012)

located_in type I terminal bouton

inferred from direct assay

(Soukup et al., 2016)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from electronic annotation with InterPro:IPR004148

(InterPro Project Members, 2004-)

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000838547

(GO Reference Genome Project, 2011-)

is_active_in glutamatergic synapse

inferred from biological aspect of ancestor with PANTHER:PTN000070016

(GO Reference Genome Project, 2011-)

is_active_in membrane

inferred from biological aspect of ancestor with PANTHER:PTN009017136

(GO Reference Genome Project, 2011-)

is_active_in presynapse

inferred from biological aspect of ancestor with PANTHER:PTN000070016

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the endophilin family. (Q8T390)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis.

(UniProt, Q8T390)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\EndoA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8T390)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.47

Gene model reviewed during 5.55

Gene model reviewed during 6.61

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

EndoA-RA

FBtr0083698

NM_169838

3561

369

EndoA-RB

FBtr0083699

NM_138767

3740

369

EndoA-RC

FBtr0334522

NM_001275788

4275

369

EndoA-RD

FBtr0482690

3438

369

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

EndoA-PA

FBpp0083112

41.4

369

5.22

FBpp0083113

41.4

369

5.22

FBpp0306589

41.4

369

5.22

FBpp0428610

41.4

369

5.22

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

369 aa isoforms: EndoA-PA, EndoA-PB, EndoA-PC, EndoA-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\EndoA using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.37

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunohistochemistry

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

motor neuron

• presynaptic active zone

Comment: periactive zone

(Marie et al., 2004)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

neuromuscular junction | restricted

Comment: Presynaptic

(Verstreken et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

endoA is present in the periactive zone of the presynapse, and colocalizes witih Dap-160 and dynamin, but not precisely with Fas2.

(Marie et al., 2004)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Matta et al., 2012, Guichet et al., 2002)

located_in membrane

inferred from direct assay

(Matta et al., 2012)

located_in type I terminal bouton

inferred from direct assay

(Soukup et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\EndoA in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\EndoA

View exonic expression by tissue for Dmel\EndoA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038659

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42265/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038659

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038659

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038659

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14296

Flygut - An atlas of the Drosophila adult midgut

FBgn0038659

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\EndoA

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 37 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of EndoA

Transgenic constructs containing regulatory region of EndoA

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6181

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage, with Scer\GAL4^elav-C155

EndoA^A66W.UAS

lethal | germline clone | larval stage | recessive

lethal | larval stage | recessive

lethal | pupal stage, with Scer\GAL4^elav-C155

EndoA^A66W.UAS

lethal | recessive

lethal - all die before end of larval stage (with Df(3R)Cha7)

EndoA¹⁰

lethal - all die before end of larval stage (with EndoA¹⁰)

EndoA²⁶

lethal - all die before end of larval stage (with EndoA²⁶)

lethal - all die before end of larval stage (with EndoA^Δ4)

EndoA²⁶

lethal - all die before end of larval stage | recessive

lethal - all die before end of pupal stage (with EndoA^EP464)

lethal - all die before end of pupal stage (with EndoA^EP593)

lethal - all die before end of pupal stage (with EndoA^EP927)

lethal - all die before end of pupal stage | recessive

EndoA^EP464

lethal - all die before end of second instar larval stage

EndoA^Δ4

partially lethal - majority die

EndoA^CB05084

viable

EndoA^EP3502

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

EndoA^GD7681

viable, with EndoA^Tag:CALI(4C)

EndoA^Δ4

viable, with EndoA^Δ4

EndoA^Tag:CALI(4C)

viable, with Scer\GAL4^elav-C155

viable, with Scer\GAL4^Mef2.PR

EndoA^GD7681

viable, with Scer\GAL4^pnr-MD237

EndoA^GD7681

viable, with Scer\GAL4^tin.CΔ4

EndoA^GD7681

viable (with EndoA^EP464)

EndoA^EP3502

viable (with EndoA^EP593)

EndoA^EP3502

viable (with EndoA^EP927)

EndoA^EP3502

viable (with EndoA^EP3502)

Other Phenotypes

Allele

abnormal cell number | adult stage, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

EndoA^UAS.cBa

abnormal cell number | adult stage (with EndoA²⁶), with EndoA^UAS.cBa, Scer\GAL4^GMR57C10

EndoA^Δ4

abnormal cell number | adult stage (with EndoA^Δ4), with EndoA^UAS.cBa, Scer\GAL4^GMR57C10

EndoA²⁶

abnormal developmental rate | larval stage (with Df(3R)Cha7)

EndoA¹⁰

abnormal developmental rate | larval stage | recessive

EndoA¹⁰

abnormal neuroanatomy

abnormal neuroanatomy, with Scer\GAL4^arm.PS

EndoA^EP927

abnormal neuroanatomy, with Scer\GAL4^rn-GAL4-14

EndoA^EP927

abnormal neuroanatomy (with EndoA^EP927)

EndoA^Δ4

abnormal neuroanatomy (with EndoA^EP927), with Scer\GAL4^rn-GAL4-14

EndoA^Δ4

abnormal neuroanatomy (with EndoA^Δ4)

EndoA^EP927

abnormal neuroanatomy (with EndoA^Δ4), with Scer\GAL4^rn-GAL4-14

EndoA^EP927

abnormal neuroanatomy | larval stage

abnormal neuroanatomy | larval stage (with EndoA¹⁰)

EndoA²⁶

abnormal neuroanatomy | larval stage (with EndoA²⁶)

EndoA¹⁰

abnormal neuroanatomy | recessive | somatic clone

EndoA^EP927

abnormal neuroanatomy | somatic clone

EndoA^EP927

abnormal neurophysiology

abnormal neurophysiology, with Scer\GAL4^arm.PS

EndoA^EP927

abnormal neurophysiology | adult stage, with EndoA²⁶, Scer\GAL4^GMR.long

abnormal neurophysiology | adult stage, with EndoA^D265A.UAS, Scer\GAL4^GMR.long

EndoA²⁶

abnormal neurophysiology | adult stage, with EndoA^D265R.UAS, Scer\GAL4^GMR.long

EndoA²⁶

abnormal neurophysiology | adult stage | conditional, with EndoA²⁶/EndoA^Δ4

abnormal neurophysiology | adult stage | conditional (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

abnormal neurophysiology | adult stage | conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

abnormal neurophysiology | adult stage | conditional (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

abnormal neurophysiology | adult stage | conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

abnormal neurophysiology | adult stage | progressive | somatic clone | conditional

EndoA^Δ4

abnormal neurophysiology | larval stage (with EndoA¹⁰)

EndoA²⁶

abnormal neurophysiology | larval stage (with EndoA²⁶)

EndoA¹⁰

abnormal neurophysiology | recessive

EndoA^EP927

abnormal neurophysiology | recessive | somatic clone

EndoA^EP927

abnormal neurophysiology | somatic clone

EndoA^EP927

abnormal phototaxis | somatic clone

EndoA^EP927

decreased cell number | adult stage, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

decreased cell number | adult stage (with EndoA²⁶), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

decreased cell number | adult stage (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

decreased cell number | adult stage (with EndoA^Δ4), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

decreased cell number | adult stage (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

decreased cell number | adult stage | conditional, with EndoA²⁶/EndoA^Δ4

decreased cell number | adult stage | conditional (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

decreased cell number | adult stage | conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

decreased cell number | adult stage | conditional (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

decreased cell number | adult stage | conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

decreased cell number | adult stage | somatic clone | conditional

EndoA^Δ4

decreased rate of movement | larval stage | recessive

EndoA^EP927

paralytic | germline clone | larval stage | recessive

EndoA¹⁰

paralytic | larval stage

EndoA²⁶

paralytic | larval stage (with Df(3R)Cha7)

EndoA¹⁰

paralytic | larval stage (with EndoA¹⁰)

EndoA²⁶

paralytic | larval stage (with EndoA²⁶)

EndoA¹⁰

paralytic | larval stage | recessive

EndoA¹⁰

short lived, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

short lived (with EndoA²⁶), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

short lived (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

short lived (with EndoA^Δ4), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

short lived (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

some die during larval stage (with Df(3R)Cha7)

EndoA¹⁰

some die during larval stage (with EndoA¹⁰)

EndoA²⁶

some die during larval stage (with EndoA²⁶)

EndoA¹⁰

some die during larval stage | recessive

some die during pupal stage (with EndoA^EP464)

some die during pupal stage (with EndoA^EP593)

some die during pupal stage (with EndoA^EP927)

some die during pupal stage | recessive

EndoA^EP464

some die during second instar larval stage

EndoA^Δ4

uncoordinated, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

uncoordinated (with EndoA²⁶), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

uncoordinated (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

uncoordinated (with EndoA^Δ4), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

uncoordinated (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

visible | adult stage, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

visible | adult stage (with EndoA²⁶), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

visible | adult stage (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

visible | adult stage (with EndoA^Δ4), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

visible | adult stage (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

Phenotype manifest in

Allele

adult pars intercerebralis, with Scer\GAL4^{Stat92E-0092-G4}

EndoA^JF02758

autolysosome | increased number | larval stage | nutrition conditional, with EndoA²⁶/EndoA^Δ4

EndoA^S75D.CyPet

autolysosome | increased number | larval stage | nutrition conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

autolysosome | increased number | larval stage | nutrition conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

autophagosome | increased number | larval stage | nutrition conditional, with EndoA²⁶/EndoA^Δ4

EndoA^S75D.CyPet

autophagosome | increased number | larval stage | nutrition conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

autophagosome | increased number | larval stage | nutrition conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

autophagosome | third instar larval stage | conditional, with EndoA^Tag:CALI(4C)

EndoA^Δ4

autophagosome | third instar larval stage | conditional, with EndoA^Δ4

EndoA^Tag:CALI(4C)

autophagosome | third instar larval stage | nutrition conditional, with EndoA²⁶/EndoA^Δ4

autophagosome | third instar larval stage | nutrition conditional (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

autophagosome | third instar larval stage | nutrition conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

autophagosome | third instar larval stage | nutrition conditional (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

autophagosome | third instar larval stage | nutrition conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

bouton

EndoA^EP927

bouton | increased number

EndoA^unspecified

bouton | increased number, with Scer\GAL4^elav-C155

EndoA^EP927

dopaminergic PPL1 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

dopaminergic PPL1 neuron | adult stage | decreased number (with EndoA²⁶), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

dopaminergic PPL1 neuron | adult stage | decreased number (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

dopaminergic PPL1 neuron | adult stage | decreased number (with EndoA^Δ4), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

dopaminergic PPL1 neuron | adult stage | decreased number (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

dopaminergic PPL1 neuron | adult stage | progressive, with EndoA²⁶/EndoA^Δ4

dopaminergic PPL1 neuron | adult stage | progressive (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

dopaminergic PPL1 neuron | adult stage | progressive (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

dopaminergic PPL1 neuron | adult stage | progressive (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

dopaminergic PPL1 neuron | adult stage | progressive (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

dopaminergic PPM2 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

dopaminergic PPM2 neuron | adult stage | decreased number (with EndoA²⁶), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

dopaminergic PPM2 neuron | adult stage | decreased number (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

dopaminergic PPM2 neuron | adult stage | decreased number (with EndoA^Δ4), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

dopaminergic PPM2 neuron | adult stage | decreased number (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

dopaminergic PPM3 neuron | adult stage, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

EndoA^UAS.cBa

dopaminergic PPM3 neuron | adult stage (with EndoA²⁶), with EndoA^UAS.cBa, Scer\GAL4^GMR57C10

EndoA^Δ4

dopaminergic PPM3 neuron | adult stage (with EndoA^Δ4), with EndoA^UAS.cBa, Scer\GAL4^GMR57C10

EndoA²⁶

dopaminergic PPM3 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

EndoA^D265R.UAS

dopaminergic PPM3 neuron | adult stage | decreased number (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

dopaminergic PPM3 neuron | adult stage | decreased number (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

dopaminergic PPM3 neuron | adult stage | progressive, with EndoA²⁶/EndoA^Δ4

dopaminergic PPM3 neuron | adult stage | progressive (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

dopaminergic PPM3 neuron | adult stage | progressive (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

dopaminergic PPM3 neuron | adult stage | progressive (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

dopaminergic PPM3 neuron | adult stage | progressive (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

embryonic/larval neuromuscular junction, with Scer\GAL4^arm.PS

EndoA^EP927

embryonic/larval neuromuscular junction | larval stage | nutrition conditional, with EndoA²⁶/EndoA^Δ4

EndoA^S75D.CyPet

embryonic/larval neuromuscular junction | larval stage | nutrition conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

embryonic/larval neuromuscular junction | larval stage | nutrition conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

eye, with EndoA^A66W.UAS, Scer\GAL4^elav-C155

EndoA^Δ4

eye, with EndoA^Δ4, Scer\GAL4^elav-C155

EndoA^A66W.UAS

eye, with Scer\GAL4^elav-C155

EndoA^A66W.UAS

eye photoreceptor cell & synaptic vesicle | somatic clone

EndoA^EP927

eye photoreceptor cell | somatic clone

EndoA^EP927

interommatidial bristle, with Scer\GAL4^elav-C155

EndoA^A66W.UAS

lamina | adult stage | conditional, with EndoA²⁶/EndoA^Δ4

lamina | adult stage | conditional (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

lamina | adult stage | conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

lamina | adult stage | conditional (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

lamina | adult stage | conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

lamina | adult stage | somatic clone | conditional

EndoA^Δ4

motor neuron

EndoA^unspecified

NMJ bouton | increased number

EndoA^Δ4

NMJ bouton | increased number, with Scer\GAL4^rn-GAL4-14

EndoA^EP927

NMJ bouton | increased number (with EndoA^EP927)

EndoA^Δ4

NMJ bouton | increased number (with EndoA^EP927), with Scer\GAL4^rn-GAL4-14

EndoA^Δ4

NMJ bouton | increased number (with EndoA^Δ4)

EndoA^EP927

NMJ bouton | increased number (with EndoA^Δ4), with Scer\GAL4^rn-GAL4-14

EndoA^EP927

NMJ bouton | larval stage | increased number

EndoA^EY02730

NMJ bouton | larval stage | nutrition conditional, with EndoA²⁶/EndoA^Δ4

EndoA^S75D.CyPet

NMJ bouton | larval stage | nutrition conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

NMJ bouton | larval stage | nutrition conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

ommatidium, with Scer\GAL4^elav-C155

EndoA^A66W.UAS

ommatidium | adult stage, with EndoA²⁶, Scer\GAL4^GMR.long

ommatidium | adult stage, with EndoA^D265A.UAS, Scer\GAL4^GMR.long

EndoA²⁶

ommatidium | adult stage, with EndoA^D265R.UAS, Scer\GAL4^GMR.long

EndoA²⁶

ommatidium | adult stage | conditional, with EndoA²⁶/EndoA^Δ4

ommatidium | adult stage | conditional (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

ommatidium | adult stage | conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

ommatidium | adult stage | conditional (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

ommatidium | adult stage | conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

ommatidium | adult stage | somatic clone | conditional

EndoA^Δ4

photoreceptor cell & synaptic vesicle | somatic clone

EndoA^EP927

photoreceptor neuron | adult stage | conditional, with EndoA²⁶/EndoA^Δ4

photoreceptor neuron | adult stage | conditional (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

photoreceptor neuron | adult stage | conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

photoreceptor neuron | adult stage | conditional (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

photoreceptor neuron | adult stage | conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

photoreceptor neuron | adult stage | somatic clone | conditional

EndoA^Δ4

presynaptic active zone

EndoA^Δ4

presynaptic active zone, with Scer\GAL4^rn-GAL4-14

EndoA^EP927

presynaptic active zone (with EndoA^EP927)

EndoA^Δ4

presynaptic active zone (with EndoA^EP927), with Scer\GAL4^rn-GAL4-14

EndoA^Δ4

presynaptic active zone (with EndoA^Δ4)

EndoA^EP927

presynaptic active zone (with EndoA^Δ4), with Scer\GAL4^rn-GAL4-14

EndoA^EP927

retina | adult stage, with EndoA²⁶, Scer\GAL4^GMR.long

retina | adult stage, with EndoA^D265A.UAS, Scer\GAL4^GMR.long

EndoA²⁶

retina | adult stage, with EndoA^D265R.UAS, Scer\GAL4^GMR.long

EndoA²⁶

retina | somatic clone

EndoA^EP927

rhabdomere | adult stage | conditional, with EndoA²⁶/EndoA^Δ4

rhabdomere | adult stage | conditional (with EndoA²⁶), with EndoA^S75A.CyPet

EndoA^Δ4

rhabdomere | adult stage | conditional (with EndoA²⁶), with EndoA^S75D.CyPet

EndoA^Δ4

rhabdomere | adult stage | conditional (with EndoA^Δ4), with EndoA^S75A.CyPet

EndoA²⁶

rhabdomere | adult stage | conditional (with EndoA^Δ4), with EndoA^S75D.CyPet

EndoA²⁶

rhabdomere | adult stage | somatic clone | conditional

EndoA^Δ4

synapse

EndoA^EP927

synapse (with EndoA^EP927)

EndoA^Δ4

synapse (with EndoA^Δ4)

EndoA^EP927

synaptic vesicle

EndoA^EP927

terminal bouton | adult stage | increased number, with Scer\GAL4^{Stat92E-0092-G4}

EndoA^JF02758

wing, with EndoA²⁶/EndoA^Δ4, Scer\GAL4^GMR57C10

wing, with Scer\GAL4^elav-C155

EndoA^A66W.UAS

wing (with EndoA²⁶), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

wing (with EndoA²⁶), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA^Δ4

wing (with EndoA^Δ4), with EndoA^D265A.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

wing (with EndoA^Δ4), with EndoA^D265R.UAS, Scer\GAL4^GMR57C10

EndoA²⁶

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (26)

Hsap\SH3GL3

14 of 14

Yes

Hsap\SH3GL1

12 of 14

Yes

Hsap\SH3GL2

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SORBS3

1 of 14

Hsap\VAV1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (26)

Rnor\Sh3gl3

14 of 14

Yes

Rnor\Sh3gl1

12 of 14

Yes

Rnor\Sh3gl2

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (27)

Mmus\Sh3gl3

14 of 14

Yes

Mmus\Sh3gl1

12 of 14

Yes

Mmus\Sh3gl2

12 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\sh3gl3

11 of 13

Yes

Xtro\sh3gl1

10 of 13

Yes

Xtro\sh3gl2

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\nck1

1 of 13

Xtro\sh3rf1

1 of 13

Xtro\trappc5

1 of 13

Danio rerio (Zebrafish) (32)

Drer\sh3gl3a

13 of 14

Yes

Drer\sh3gl3b

13 of 14

Yes

Drer\sh3gl1a

12 of 14

Yes

Drer\sh3gl1b

12 of 14

Yes

Drer\sh3gl2a

12 of 14

Yes

Drer\sh3gl2b

8 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\unc-57

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP004766

11 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\AT1G31440

4 of 13

Yes

Atha\AT4G18060

4 of 13

Yes

Atha\AT4G34660

4 of 13

Yes

Atha\AGD2

1 of 13

Atha\AGD4

1 of 13

Atha\SFC

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\LSB3

2 of 13

Yes

Scer\YSC84

2 of 13

Yes

Scer\NBP2

1 of 13

Scer\RVS167

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\mug137

7 of 12

Yes

Spom\SPBC19C2.10

6 of 12

Yes

Spom\SPBC119.05c

2 of 12

Yes

Spom\abp1

1 of 12

Spom\skb5

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:EndoA. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

EndoB

3 of 13

CAP

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

drk

1 of 13

Nost

1 of 13

nwk

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Parkinson disease, susceptibility to, SH3GL2-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SH3GL1; SH3 domain containing GRB2 like 1, endophilin A2

model of acute myeloid leukemia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

EndoA^UAS.cVa

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Yu et al., 2020)

EndoA^GD7681

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

EndoA^JF02758

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

exacerbates Parkinson's disease

modeled by Hsc70-5^KK100233

(Zhu et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SH3GL3; SH3 domain containing GRB2 like 3, endophilin A3

14 of 14

603362

SH3GL1; SH3 domain containing GRB2 like 1, endophilin A2

12 of 14

601768

LEUKEMIA, ACUTE MYELOID; AML

acute myeloid leukemia

SH3GL2; SH3 domain containing GRB2 like 2, endophilin A1

12 of 14

SH3 DOMAIN, GRB2-LIKE, 2; SH3GL2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

EndoA

two hybrid, molecular sieving, light scattering

(Bademosi et al., 2023, Hu et al., 2017.6.13)

EndoA - Atg9

anti tag coimmunoprecipitation, western blot

(Soukup et al., 2016)

EndoA - Lrrk

enzymatic study, autoradiography

(Matta et al., 2012)

EndoA - Synj

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, pull down

(Geng et al., 2016, Chen et al., 2014, Verstreken et al., 2003)

EndoA - l(3)05822

two hybrid

(Hu et al., 2017.6.13)

EndoA - shi

anti bait coimmunoprecipitation, western blot, pull down

(Bademosi et al., 2023, Chen et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

EndoA

suppressible

EndoA::Hsap\ARFIP2

(Jung et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Li et al., 2010)

enhanceable

(Menon et al., 2015)

enhanceable

(Zhu et al., 2021)

suppressible

(Soukup et al., 2016, Matta et al., 2012)

nwk

enhanceable

EndoA

(O'Connor-Giles et al., 2008)

Ppt1

enhanceable

EndoA

(Buff et al., 2007)

shi

suppressible

EndoA

(Fabian-Fine et al., 2003)

Synj

enhanceable

EndoA

(Verstreken et al., 2003)

Synj

suppressible

EndoA

(Verstreken et al., 2003)

Vps35

suppressible

EndoA

(Inoshita et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67269

DroID - A comprehensive database of gene and protein interactions.

FBgn0038659

MIST (genetic) - An integrated Molecular Interaction Database

42265

MIST (protein-protein) - An integrated Molecular Interaction Database

42265

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q8T390

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011, Stapleton et al., 2006)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-65

Cytogenetic map

91D4-91D4

Sequence location

3R:18,906,609..18,911,117 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

91D4-91D4

Limits computationally determined from genome sequence between P{PZ}sprd⁰⁵²⁸⁴ and P{PZ}cdi⁰⁷⁰¹³&P{lacW}nos^j3B6

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

91D5-91D5

(Verstreken, 2001.9.28)

91D-91F

(Lloyd et al., 2000)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

3-65

(FlyBase, 2016)

3-64.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

26690

y¹ w^*; P{UAS-endo.V}I-III

27679

y¹ v¹; P{TRiP.JF02758}attP2

93757

w^*; EndoA^KO/TM3, Sb¹

65648

w¹¹¹⁸; PBac{IT.GAL4}EndoA^1285-G4

56298

y¹ w^*; Mi{MIC}EndoA^MI11164

92524

y¹ v¹; P{U6.2-EndoA.dgRNA}attP40/CyO

15590

y¹ w^67c23; P{EPgy2}EndoA^EY02730

24881

w^*; P{neoFRT}82B P{EP}EndoA^EP927/TM6B, Tb¹

FlyORF

F002371

M{UAS-EndoA.ORF.3xHA.GW}ZH-86Fb

Kyoto

126242

w¹¹¹⁸; P{RS5}EndoA^5-SZ-3942

VDRC

v110642

P{KK108259}VIE-260B

v24617

w¹¹¹⁸; P{GD7681}v24617

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (186)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI05371

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038659

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038659

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Matta et al., 2012, Rikhy et al., 2002)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

endoA is essential for synaptic vesicle endocytosis, being required from the onset of budding until fission.

(Guichet et al., 2002)

endoA is required presynapticlly at the neuromuscular junction and has a role in endocytosis.

(Verstreken et al., 2002)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: endophilin CG14296

(Verstreken and Bellen, 2000.9.4)

Source for identity of: EndoA endoA

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG14296

(Trivedi et al., 2020, Balakrishnan et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, Guichet et al., 2002, Whitfield et al., 2002)

D-endo

(Kjaerulff et al., 2001)

D-endoA

(Guichet et al., 2002)

Dendo-A

(Richmond and Broadie, 2002)

Endo

(Geng et al., 2016, Chen et al., 2014, Maldonado et al., 2013, Verstreken et al., 2009, Koh et al., 2007, Koh et al., 2004, Marie et al., 2004, Rikhy et al., 2002)

EndoA

(Ciampelli et al., 2025, Crane et al., 2025, Baisgaard et al., 2023, Zhu et al., 2021, Yu et al., 2020, Jiang et al., 2019, Weiss et al., 2019, Kuznetsova et al., 2018, Stephano et al., 2018, Xiong and Yu, 2018, Hu et al., 2017.6.13, Clandinin and Owens, 2016-, Soukup et al., 2016, West et al., 2015, Kasprowicz et al., 2014, Bajpe et al., 2008)

endo

(Goel and Dickman, 2021, Poovathumkadavil and Jagla, 2020, Vanlandingham et al., 2013, Dickman and Davis, 2009, Venken et al., 2009, O'Connor-Giles et al., 2008, Venken et al., 2008, Dickman, 2006, Fabian-Fine et al., 2003, Verstreken et al., 2003)

Name Synonyms

Endophilin

(Geng et al., 2016, Verstreken et al., 2009, Verstreken and Bellen, 2006, Rikhy et al., 2002)

Endophilin A

(Buff et al., 2007)

Endophilin-A

(Jung et al., 2010)

EndophilinA

(Font-Burgada et al., 2008)

endophilin

(Maldonado et al., 2013, Chang and Min, 2009, Venken et al., 2008, Koh et al., 2007, Mattaliano et al., 2007, Dickman et al., 2006, McNiven, 2006, Babcock et al., 2004, Broadie, 2004, Zhen and Jin, 2004, Kjaerulff et al., 2002, Lloyd et al., 2000, Verstreken and Bellen, 2000.9.4)

endophilin A

(Langston et al., 2016, Korey et al., 2007, Korolchuk et al., 2007)

endophilinA

(Uytterhoeven et al., 2015, Li et al., 2010)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 61 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42265

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8T390

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q8T390

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

B5RIU6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8T390

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038659

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42265/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038659

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038659

FlyMine - An integrated database for Drosophila genomics

FBgn0038659

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG14296

MARRVEL_MODEL - MARRVEL (model organism gene)

42265

Linkouts

BioGRID - A database of protein and genetic interactions.

67269

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038659

DroID - A comprehensive database of gene and protein interactions.

FBgn0038659

DRSC - Results frm RNAi screens

FBgn0038659

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038659

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038659

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14296

Flygut - An atlas of the Drosophila adult midgut

FBgn0038659

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038659

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004801

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Endocytosis

MIST (genetic) - An integrated Molecular Interaction Database

42265

MIST (protein-protein) - An integrated Molecular Interaction Database

42265

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q8T390

References (125)

The following external sites may use different assemblies or annotations than FlyBase.

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