FlyBase Allele Report: Scer\GAL4[GMR57C10]

A 824 base pair fragment from the n-syb region, including the putative endogenous n-syb promoter, is fused upstream of sequence encoding a GAL4 driver.

(Pfeiffer et al., 2011.2.9)

Allele components

Component

Use(s)

Regulatory region(s)

GMR57C10

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage -- third instar larval stage

neuron

(Eschbach et al., 2021)

adult stage

adult optic lobe neuron | subset

(Wu et al., 2016, Nern et al., 2015)

neuron

(Massey et al., 2019)

adult neuron

(Klapoetke et al., 2022)

Additional Information

Statement

Reference

Drives expression in a subset of optic lobe neurons.

(FlyBase Curators, 2017)

ScerGAL4^GMR57C10, in combination with KlacKDR^{GMR29C07.Switch-4}, drives expression stochastically in optic lobe neurons.

(Wu et al., 2016)

Marker for

adult neuron

(Klapoetke et al., 2022)

neuron

(Eschbach et al., 2021)

Reflects expression of

nSyb

(Massey et al., 2019)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | P-stage, with Lgr3^GL01056

(Heredia et al., 2021)

abnormal cell number | adult stage, with EndoA²⁶/EndoA^Δ4, EndoA^UAS.cBa

(Bademosi et al., 2023)

abnormal circadian rhythm | adult stage, with Mmus\Nos2^Mac.UAS

(Kozlov et al., 2020)

abnormal circadian rhythm | adult stage, with Nos^GD12013

(Kozlov et al., 2020)

abnormal courtship behavior, with dsx^RNAi.UAS.M2

(Han et al., 2022)

abnormal courtship behavior, with dsx^TH13361.N

(Han et al., 2022)

abnormal mating, with dsx^RNAi.UAS.M2

(Han et al., 2022)

abnormal mating, with dsx^TH13361.N

(Han et al., 2022)

abnormal mating behavior, with dsx^TH13362.N

(Han et al., 2022)

decreased cell number | adult stage, with EndoA²⁶/EndoA^Δ4, EndoA^D265A.UAS

(Bademosi et al., 2023)

decreased cell number | adult stage, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

decreased rate of adult locomotory behavior | progressive, with Mtx2^EGFP/Mtx2^ΔDsRed, Scer\FLP1^UAS.cUa

(Zhang et al., 2025)

decreased rate of courtship behavior, with dsx^TH13361.N

(Han et al., 2022)

paralytic | adult stage | heat sensitive, with shi^1.UAS

(Pfeiffer et al., 2012)

paralytic | adult stage | heat sensitive, with shi^{ts1.IVS.p10.20xUAS}

(Pfeiffer et al., 2012)

paralytic | adult stage | heat sensitive, with shi^{ts1.IVS.Syn21.p10.20xUAS}

(Pfeiffer et al., 2012)

short lived, with EndoA²⁶/EndoA^Δ4, EndoA^D265A.UAS

(Bademosi et al., 2023)

short lived, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

short lived, with Mtx2^EGFP/Mtx2^ΔDsRed, Scer\FLP1^UAS.cUa

(Zhang et al., 2025)

some die during P-stage, with Lgr3^GL01056

(Heredia et al., 2021)

uncoordinated, with EndoA²⁶/EndoA^Δ4, EndoA^D265A.UAS

(Bademosi et al., 2023)

uncoordinated, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

visible | adult stage, with EndoA²⁶/EndoA^Δ4, EndoA^D265A.UAS

(Bademosi et al., 2023)

visible | adult stage, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

Phenotype Manifest In

adult antennal lobe, with Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa

(Zhang et al., 2025)

adult mushroom body, with Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa

(Zhang et al., 2025)

dopaminergic PPL1 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, EndoA^D265A.UAS

(Bademosi et al., 2023)

dopaminergic PPL1 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

dopaminergic PPM2 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, EndoA^D265A.UAS

(Bademosi et al., 2023)

dopaminergic PPM2 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

dopaminergic PPM3 neuron | adult stage, with EndoA²⁶/EndoA^Δ4, EndoA^UAS.cBa

(Bademosi et al., 2023)

dopaminergic PPM3 neuron | adult stage | decreased number, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

mitochondrion | adult stage, with Mtx2^EGFP/Mtx2¹, Scer\FLP1^UAS.cUa

(Zhang et al., 2025)

wing, with EndoA²⁶/EndoA^Δ4, EndoA^D265A.UAS

(Bademosi et al., 2023)

wing, with EndoA²⁶/EndoA^Δ4, EndoA^D265R.UAS

(Bademosi et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^GMR57C10/shi^{ts1.IVS.p10.20xUAS} is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/shi^1.UAS is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/shi^{ts1.IVS.p10.20xUAS} is a suppressor of abnormal neurophysiology phenotype of para^bss1

(Kroll et al., 2015)

Rab5^{Q88L.UASp.YFP}/Scer\GAL4^GMR57C10 is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Rab8^{T22N.UASp.YFP}/Scer\GAL4^GMR57C10 is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab9^{S26N.UASp.YFP} is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Rab9^{Q71L.UASp.YFP}/Scer\GAL4^GMR57C10 is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab30^{T21N.UASp.YFP} is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab30^{Q66L.UASp.YFP} is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab32^{T33N.UASp.YFP} is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab35^S22N.UAS.YFP is a suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/shi^{ts1.IVS.p10.20xUAS} is a suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR57C10/Synj^UAS.cVa is a non-suppressor of abnormal heat stress response | adult stage phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10 is a non-suppressor of abnormal heat stress response | adult stage phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Scer\GAL4^GMR57C10/Synj^UAS.cVa is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10 is a non-suppressor of abnormal neuroanatomy | adult stage phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Rab3^{T35N.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab3^{Q80L.UASp.YFP} is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Rab3^{T35N.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab3^{Q80L.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab5^{S43N.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Rab8^{Q67L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Rab23^{S51N.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab23^{Q96L.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab27^{T25N.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab27^{Q74L.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Rab32^{Q79L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Rab35^{Q67L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab5^{S43N.UASp.YFP} is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Rab5^{Q88L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Rab8^{T22N.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab9^{S26N.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Rab9^{Q71L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab30^{T21N.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab30^{Q66L.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab32^{T33N.UASp.YFP} is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab35^S22N.UAS.YFP is a non-suppressor of bang sensitive phenotype of eas²

(Kroll et al., 2015)

Rab8^{Q67L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Rab23^{S51N.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab23^{Q96L.UASp.YFP} is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab27^{T25N.UASp.YFP} is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Scer\GAL4^GMR57C10/Rab27^{Q74L.UASp.YFP} is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Rab32^{Q79L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Rab35^{Q67L.UASp.YFP}/Scer\GAL4^GMR57C10 is a non-suppressor of bang sensitive phenotype of para^bss1

(Kroll et al., 2015)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR57C10/Synj^UAS.cVa is a non-suppressor of adult brain phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10 is a non-suppressor of adult brain phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Scer\GAL4^GMR57C10/Synj^UAS.cVa is a non-suppressor of vacuole | increased number | adult stage phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10 is a non-suppressor of vacuole | increased number | adult stage phenotype of Sgip1^KO-WS

(Decet et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Partially rescues

par-1^{UAS.RR.Tag:FLAG}/Scer\GAL4^GMR57C10 partially rescues par-1^Δ-16

(Herzmann et al., 2017)

Scer\GAL4^GMR57C10/par-1^UAS.cSa partially rescues par-1^Δ-16

(Herzmann et al., 2017)

Orai^UAS.cPa/Scer\GAL4^GMR57C10 partially rescues Orai^EY09167

(Pathak et al., 2015)

Fails to rescue

Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP fails to rescue Mtx2¹/Mtx2^ΔDsRed

(Zhang et al., 2025)

Scer\GAL4^GMR57C10/par-1^KN.UAS fails to rescue par-1^Δ-16

(Herzmann et al., 2017)

Comments

Images (0)

Mutant

Wild-type

Stocks (17)

Bloomington

39171

w¹¹¹⁸; P{GMR57C10-GAL4}attP2

90854

w^*; P{GMR57C10-GAL4}attP40; P{UAS-Cerulean.intMEMOIR}attP2/TM3, Sb¹

605702

y¹ w^* P{nanos-phiC31\int.NLS}X; P{AD1(phiC31),R57C10-GAL4}attP40/CyO

605712

y¹ M{vas-Bxb1.nanos3'UTR.RFP-}ZH-2A w^*; P{AD1(Bxb1),R57C10-GAL4}attP2

605713

y¹ M{vas-Bxb1.nanos3'UTR.RFP-}ZH-2A w^*; P{R57C10-GAL4,AD2(Bxb1)}attP2

58763

w^*; P{UAS-CaMPARI}attP40; PBac{GMR57C10-GAL4}VK00040 PBac{GMR57C10-GAL4}VK00020

605707

y¹ M{vas-Bxb1.nanos3'UTR.RFP-}ZH-2A w^*; P{AD1(Bxb1),R57C10-GAL4}attP40

58764

w^*; P{UAS-CaMPARI.V398D}attP40; PBac{GMR57C10-GAL4}VK00040 PBac{GMR57C10-GAL4}VK00020

81082

w¹¹¹⁸ P{13XLexAop2-IVS-CsChrimson.mVenus}attP18; P{GMR57C10-GAL4}attP40/CyO; PBac{UAS-CaMPARI2}VK00005

605706

y¹ w^* P{nanos-phiC31\int.NLS}X; P{10XUAS-IVS-myr::tdTomato,R57C10-GAL4,AD2(phiC31)}attP40/CyO

81088

w¹¹¹⁸ P{13XLexAop2-IVS-CsChrimson.mVenus}attP18 P{UAS-CaMPARI2.L398T}su(Hw)attP8; P{GMR57C10-GAL4}attP40/CyO

605711

y¹ M{vas-Bxb1.nanos3'UTR.RFP-}ZH-2A w^*; P{10XUAS-IVS-myr::tdTomato,R57C10-GAL4,AD2(Bxb1)}attP40/CyO

More stocks available...

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

GAL4^R57C10

(Rode et al., 2018)

Scer\GAL4^GMR57C10

nSyb³⁰⁵⁸⁹

(Pathak et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (115)

Report Sections

Open Close