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General Information
Symbol
Dmel\OraiEY09167
Species
D. melanogaster
Name
FlyBase ID
FBal0158867
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Orai3
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion components
P{EPgy2}OraiEY09167
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

olf186-FEY09167 homozygous larvae are smaller and developmentally delayed and majority of them die as third instar larvae, the body size of the surviving adults is significantly reduced compared to controls.

Adult viability of olf186-FEY09167 mutants is found to be approximately 20%. Their lethality is very likely in the larval stages because all pupae eclosed as adults.

Adults that enclose appear smaller than wild-type and have outspread wings. olf186-FEY09167 mutants are flightless.

The normal pattern of action potentials in response to an air puff is absent in olf186-FEY09167 flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Stimko/+;olf186-FEY09167/+ double heterozygotes show reduced eclosion rate as significantly fewer adults emerge compared to wild-type and the single heterozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The developmental delay, small body size and partial lethality of olf186-FEY09167 homozygous mutants is rescued by expression of olf186-FScer\UAS.cZa under the control of the Scer\GAL4elav-C155 driver. The lethality is also partially rescued when the expression is driven by either Scer\GAL4ple.PF or Scer\GAL4VGlut-OK371, no rescue is observed with either Scer\GAL4dimm-929 or Scer\GAL4Mef2.PR drivers.

A small but significant rescue of the flight deficit in olf186-FEY09167 is obtained by neuronal expression of olf186-FScer\UAS.cPa under the control of Scer\GAL4GMR57C10.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)