FlyBase Allele Report: Dmel\Sgip1[KO-WS]

General Information

Symbol

Dmel\Sgip1^KO-WS

Species

D. melanogaster

Name

FlyBase ID

FBal0406103

Feature type

allele

Associated gene

Dmel\Sgip1

Associated Insertion(s)

TI{TI}Sgip1^KO-WS

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Decet et al., 2024)

Mutagen

CRISPR/Cas9

(Decet et al., 2024)

gene targeting by homologous recombination

(Decet et al., 2024)

Progenitor genotype

Associated Insertion(s)

TI{TI}Sgip1^KO-WS

Cytology

Description

The Sgip1 coding region is replaced by mini-white.

(Decet et al., 2024)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3R:9,521,011..9,521,350 [+]

Comment:

The Sgip1 first coding exon is replaced by mini-white. Position of deletion endpoints on reference sequence estimatedd from reported primer sequences used to generate homology arms.

(Decet et al., 2024)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of early-onset Parkinson's disease

CEA

(Decet et al., 2024)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Sgip1^KO-WS has abnormal heat stress response | adult stage phenotype, non-suppressible by Scer\GAL4^GMR57C10/Synj^UAS.cVa

(Decet et al., 2024)

Sgip1^KO-WS has abnormal heat stress response | adult stage phenotype, non-suppressible by Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10

(Decet et al., 2024)

Sgip1^KO-WS has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Scer\GAL4^GMR57C10/Synj^UAS.cVa

(Decet et al., 2024)

Sgip1^KO-WS has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10

(Decet et al., 2024)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Sgip1^KO-WS has adult brain phenotype, non-suppressible by Scer\GAL4^GMR57C10/Synj^UAS.cVa

(Decet et al., 2024)

Sgip1^KO-WS has adult brain phenotype, non-suppressible by Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10

(Decet et al., 2024)

Sgip1^KO-WS has vacuole | increased number | adult stage phenotype, non-suppressible by Scer\GAL4^GMR57C10/Synj^UAS.cVa

(Decet et al., 2024)

Sgip1^KO-WS has vacuole | increased number | adult stage phenotype, non-suppressible by Syt1^{DF-N.UAS.pHluorinSE.mCherry}/Scer\GAL4^GMR57C10

(Decet et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG8176^KO-WS

(Decet et al., 2024)

Sgip1^KO-WS

dSgip1^KO-WS

(Decet et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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