FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SynjUAS.cVa
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General Information
Symbol
Dmel\SynjUAS.cVa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Vanhauwaert
FlyBase ID
FBal0327485
Feature type
allele
Associated gene
Dmel\Synj
Associated Insertion(s)
Carried in Construct
PBac{UAS-Synj.V}
Also Known As
UAS-synj
Key Links
Transgenic product class
wild_type
(Vanhauwaert et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Vanhauwaert et al., 2017)
Mutagen
in vitro construct
(Vanhauwaert et al., 2017)
Progenitor genotype
Carried in construct
PBac{UAS-Synj.V}
Cytology
Description

UASt regulatory sequences drive expression of Synj.

(Vanhauwaert et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Synj
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Synj1, Synj2
      (Vanhauwaert et al., 2017)
      ameliorates  Parkinson's disease 19A
      modeled by auxRG.HA
      (Jacquemyn et al., 2023)
      modeled by auxF956X, auxRG.HA
      (Jacquemyn et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Synj1/Synj2 transheterozygotes expressing SynjScer\UAS.cVa under the control of Scer\GAL4nSyb.PU present insignificant differences in adult lifespan under starvation conditions and in the number of intact ommatidia upon 7 day exposure to either constant light or constant darkness, as compared to controls; their third instar larval neuromuscular junctions do not present any significant defects, as shown by insignificant differences in the amplitude and frequency of miniature and spontaneous excitatory junctional currents under basal conditions, and by an apparently normal induction of mature autophagosomes (detected as fluorescent Atg8 puncta) in response to direct electric nerve stimulation, as compared to controls.

      (Vanhauwaert et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4GMR57C10/SynjUAS.cVa is a non-suppressor of adult brain phenotype of Sgip1KO-WS

      (Decet et al., 2024)

      Scer\GAL4GMR57C10/SynjUAS.cVa is a non-suppressor of vacuole | increased number | adult stage phenotype of Sgip1KO-WS

      (Decet et al., 2024)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      SynjUAS.cVa/Scer\GAL4GH146 rescues SynjR258Q

      (Pech et al., 2025)

      Scer\GAL4nSyb.PU/SynjUAS.cVa rescues Synj1

      (Vanhauwaert et al., 2017)

      Scer\GAL4nSyb.PU/SynjUAS.cVa rescues Synj2/Synj1

      (Vanhauwaert et al., 2017)

      Scer\GAL4Toll-6-D42/SynjUAS.cVa rescues Synj2/Synj1

      (Vanhauwaert et al., 2017)
      Comments

      The expression of SynjScer\UAS.cVa under the control of Scer\GAL4nSyb.PU rescues the larval lethality of Synj1/Synj2 transheterozygotes; this expression also rescues the decreased synaptic transmission in electroretinograms measured in Synj1 homozygous eyes within mosaic adults, as compared to controls.

      The expression of SynjScer\UAS.cVa under the control of Scer\GAL4Toll-6-D42 rescues the third instar larval neuromuscular junction defects of Synj1/Synj2 transheterozygotes, as it suppresses the failure to sustain neurotransmission under high stimulation conditions and suppresses all the following presynaptic defects: the increase number of satellite boutons, the decrease in endocytosis levels, the failure to starvation-induce mature autophagosomes (detected as fluorescent Atg8 puncta) and autolysosomes (detected as fluorescent Lamp1 puncta), and the concomitant decrease in synaptic vesicles density and increase in cisternae density at boutons under starvation conditions.

      (Vanhauwaert et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SynjScer\UAS.cVa
      SynjUAS.cVa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Vanhauwaert
      Secondary FlyBase IDs
        References (5)