FB2026_02 , released June 18, 2026
Allele: Dmel\auxRG.HA
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General Information
Symbol
Dmel\auxRG.HA
Species
D. melanogaster
Name
FlyBase ID
FBal0388241
Feature type
allele
Associated gene
Dmel\aux
Associated Insertion(s)
TI{TI}auxRG.HA
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Jacquemyn et al., 2023)
phiC31 integrase
(Jacquemyn et al., 2023)
Progenitor genotype
Associated Insertion(s)
TI{TI}auxRG.HA
Cytology
Description

Amino acid replacement: R1119G.

(Jacquemyn et al., 2023)

Endogenous aux is replaced with aux containing the R1119G mutation (orthologous to the human disease-related R927G mutation) and tagged with Tag:HA at the N-terminal.

(Jacquemyn et al., 2023)
Allele components
Component
Use(s)
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:4,226,659..4,226,659 [+]
Nucleotide change:

C4226659G

Amino acid change:

R1119G | aux-PA; R1119G | aux-PB; R1107G | aux-PC; R1111G | aux-PD

Reported amino acid change:

R1119G

Comment:

Analogous mutation in human DNAJC6 implicated in Parkinson disease, susceptibility to, auxilin-related and Parkinson disease 19A/B, early-onset; mutation at endogenous aux locus; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Jacquemyn et al., 2023)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease 19A
      CEC
      (Jacquemyn et al., 2023)
      CEC with auxF956X
      (Jacquemyn et al., 2023)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Parkinson's disease 19A
      is ameliorated by SynjUAS.cVa
      (Jacquemyn et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Jacquemyn et al., 2023)
      DNAJC6:p.Arg927Gly
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      DNAJC6:p.Arg857Gly
      DNAJC6:p.Arg870Gly
      Associated human disease model(s)
      External database links
      ClinVar: 253094
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HA-dAuxRG
      (Jacquemyn et al., 2023)
      auxRG.HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)