FlyBase Allele Report: Dmel\Mtx2[1]

General Information

Symbol

Dmel\Mtx2¹

Species

D. melanogaster

Name

FlyBase ID

FBal0407313

Feature type

allele

Associated gene

Dmel\Mtx2

Associated Insertion(s)

Carried in Construct

Also Known As

dMtx2¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Zhang et al., 2025)

Progenitor genotype

Cytology

Description

A single-nucleotide deletion (coding T135) in Mtx2 that is predicted to produce a short-truncated peptide.

(Zhang et al., 2025)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:19,928,230..19,928,230 [-]

Comment:

A single nucleotide deletion in codon 45 of Mtx2 causes a frameshift and early translation termination.

(Zhang et al., 2025)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Shou et al., 2026)

abnormal size | adult stage (with Mtx2^EGFP-)

(Zhang et al., 2025)

decreased size | P-stage

(Shou et al., 2026)

fertile | dominant

(Zhang et al., 2025)

lethal (with Mtx2^EGFP-)

(Shou et al., 2026)

lethal (with Mtx2^ΔDsRed)

(Shou et al., 2026)

lethal - all die during pharate adult stage (with Mtx2^EGFP-)

(Zhang et al., 2025)

lethal - all die during pharate adult stage (with Mtx2^ΔDsRed)

(Zhang et al., 2025)

lethal - all die during pharate adult stage | recessive

(Zhang et al., 2025)

lethal - all die during P-stage

(Shou et al., 2026)

short lived (with Mtx2^ΔDsRed), with Mtx2^UAS.EGFP, Scer\GAL4^Mef2.PR

(Shou et al., 2026)

short lived | female (with Mtx2^ΔDsRed), with Mtx2^UAS.EGFP, Scer\GAL4^Act5C.PU

(Shou et al., 2026)

some die during P-stage (with Mtx2^ΔDsRed)

(Shou et al., 2026)

Phenotype Manifest In

adult antennal lobe (with Mtx2^EGFP-)

(Zhang et al., 2025)

adult antennal lobe | pharate adult stage

(Zhang et al., 2025)

adult mushroom body (with Mtx2^EGFP-)

(Zhang et al., 2025)

axon | adult stage (with Mtx2^EGFP-)

(Zhang et al., 2025)

dorsal longitudinal indirect flight muscle 45c | P-stage

(Shou et al., 2026)

dorsal longitudinal indirect flight muscle | P-stage

(Shou et al., 2026)

gustatory receptor neuron of the wing (with Mtx2^EGFP-)

(Zhang et al., 2025)

mitochondrion | adult stage (with Mtx2^EGFP-)

(Zhang et al., 2025)

mitochondrion | larval stage

(Zhang et al., 2025)

mitochondrion | pharate adult stage

(Zhang et al., 2025)

mitochondrion | P-stage

(Shou et al., 2026)

muscle cell | P-stage

(Shou et al., 2026)

NMJ bouton | larval stage

(Zhang et al., 2025)

sarcomere | P-stage

(Shou et al., 2026)

wing sensillum | increased number (with Mtx2^EGFP-)

(Zhang et al., 2025)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, suppressible by Myc^UAS.cZa/Scer\GAL4^Mef2.PR

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, suppressible by Scer\GAL4^Act5C.PU/Hsap\MTX2^UAS.EGFP

(Shou et al., 2026)

NOT suppressed by

Statement

Reference

Mtx2¹ has lethal phenotype, non-suppressible by Hsap\MTX2^UAS.EGFP/Scer\GAL4^Tub.PU

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Scer\GAL4^Mef2.PR/Diap1^UASp.cPa

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Pi3K92E^UAS.cUa/Scer\GAL4^Mef2.PR

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Akt^UAS.cUa/Scer\GAL4^Mef2.PR

(Shou et al., 2026)

Mtx2¹ has lethal phenotype, non-suppressible by Scer\GAL4^Tub.PU/Hsap\MTX2^{294-295del.UAS.EGFP}

(Shou et al., 2026)

Mtx2¹ has lethal phenotype, non-suppressible by Hsap\MTX2^{603delG.UAS.EGFP}/Scer\GAL4^Tub.PU

(Shou et al., 2026)

Mtx2¹ has lethal phenotype, non-suppressible by Scer\GAL4^Tub.PU/Hsap\MTX2^{501instT.UAS.EGFP}

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed has lethal phenotype, non-suppressible by Scer\GAL4^Mef2.PR/BacA\p35^UAS.cHa

(Shou et al., 2026)

Other

Statement

Reference

Mtx2¹/Mtx2^ΔDsRed, Myc^UAS.cZa, Scer\GAL4^Mef2.PR has short lived phenotype

(Shou et al., 2026)

Hsap\MTX2^UAS.EGFP, Mtx2¹/Mtx2^ΔDsRed, Scer\GAL4^Act5C.PU has short lived phenotype

(Shou et al., 2026)

CG5662¹, Mtx2¹ has lethal - all die during pharate adult stage phenotype

(Zhang et al., 2025)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Mtx2^EGFP-/Mtx2¹ has mitochondrion | adult stage phenotype, non-enhanceable by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP-/Mtx2¹ has gustatory receptor neuron of the wing phenotype, non-enhanceable by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP-/Mtx2¹ has axon | adult stage phenotype, non-enhanceable by CG5662¹

(Zhang et al., 2025)

NOT suppressed by

Statement

Reference

Mtx2^EGFP-/Mtx2¹ has mitochondrion | adult stage phenotype, non-suppressible by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP-/Mtx2¹ has gustatory receptor neuron of the wing phenotype, non-suppressible by CG5662¹

(Zhang et al., 2025)

Mtx2^EGFP-/Mtx2¹ has axon | adult stage phenotype, non-suppressible by CG5662¹

(Zhang et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Mtx2¹ is rescued by Scer\GAL4^Mef2.PR/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Tub.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Act5C.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Mef2.PR/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2^EGFP-/Mtx2¹ is rescued by Scer\GAL4^Tub.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2^EGFP-/Mtx2¹ is rescued by Scer\GAL4^Mef2.PR/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is rescued by Scer\GAL4^Tub.PU/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Mtx2^EGFP-/Mtx2¹ is rescued by Scer\GAL4^Tub.PU/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Mtx2^EGFP-/Mtx2¹ is rescued by Scer\GAL4^GMR15B07/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Partially rescued by

Mtx2¹/Mtx2^ΔDsRed is partially rescued by Scer\GAL4^Mhc.PK/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2^EGFP-/Mtx2¹ is partially rescued by Scer\GAL4^Mhc.PK/Mtx2^UAS.EGFP

(Shou et al., 2026)

Not rescued by

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^Cg.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^repo/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^Hand.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2^EGFP-/Mtx2¹ is not rescued by Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2^EGFP-/Mtx2¹ is not rescued by Scer\GAL4^Cg.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2^EGFP-/Mtx2¹ is not rescued by Scer\GAL4^repo/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2^EGFP-/Mtx2¹ is not rescued by Scer\GAL4^Hand.PU/Mtx2^UAS.EGFP

(Shou et al., 2026)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^nSyb.PS/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Mtx2¹/Mtx2^ΔDsRed is not rescued by Scer\GAL4^GMR57C10/Mtx2^UAS.EGFP

(Zhang et al., 2025)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mtx2¹

dMtx2¹

(Shou et al., 2026, Zhang et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (2)

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