FlyBase Allele Report: Dmel\par-1[KN.UAS]

General Information

Symbol

Dmel\par-1^KN.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0146944

Feature type

allele

Associated gene

Dmel\par-1

Associated Insertion(s)

Carried in Construct

P{UAS-par-1.KN}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Sun et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-par-1.KN}

Cytology

Description

UASt regulatory sequences drive expression of a kinase negative form of par-1.

(Sun et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

par-1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology, with Scer\GAL4^Mhc.PW

(Zhang et al., 2007)

Phenotype Manifest In

embryonic/first instar larval cuticle, with Scer\GAL4^{VP16.mat.αTub67C}

(Sun et al., 2001)

ventral denticle belt, with Scer\GAL4^{VP16.mat.αTub67C}

(Sun et al., 2001)

ventral denticle belt | ectopic, with Scer\GAL4^{VP16.mat.αTub67C}

(Sun et al., 2001)

Detailed Description

Statement

Reference

Expression of par-1^KN.Scer\UAS under the control of Scer\GAL4^elav.PU has no significant effect on the number of boutons or branching complexity at the neuromuscular junction of muscle 6/7.

The frequency and amplitude of the miniature excitatory junctional current of animals expressing par-1^KN.Scer\UAS under the control of under the control of Scer\GAL4^Mhc.PW are not altered compared to controls. The amplitude of the evoked excitatory junctional current is increased compared to controls and the quantal content is increased.

(Zhang et al., 2007)

Flies expressing par-1^KN.Scer\UAS under the control of Scer\GAL4^hs.2sev do not have a mutant eye phenotype.

(Nishimura et al., 2004)

Expression of par-1^KN.Scer\UAS under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in embryos with localised ectopic denticle formation and fusion of denticle belts.

(Sun et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to rescue

Scer\GAL4^GMR57C10/par-1^KN.UAS fails to rescue par-1^Δ-16

(Herzmann et al., 2017)

Comments

The pruning defects observed in class IV dendritic arborizing neuron par-1^Δ-16 mutant MARCM clones cannot be rescued by expression of par-1^KN.Scer\UAS (with Scer\GAL4^GMR57C10) in the mutant clones.

(Herzmann et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

par-1^KN.Scer\UAS

par-1^KN.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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