FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\drk
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General Information
Symbol
Dmel\drk
Species
D. melanogaster
Name
downstream of receptor kinase
Annotation Symbol
CG6033
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004638
Gene Model Status
Current
Stock Availability
27 publicly available
Gene Summary
downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory). [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)
All Summaries
Also Known As

E(sev)2B, Grb2, l(2)k13809, Drk/Grb2, l(2)10626

Key Links
Genomic Location
Cytogenetic map
50A13-50A13
Sequence location
Recombination map
2-68
RefSeq locus
NT_033778 REGION:13495222..13502841
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (33 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
enables epidermal growth factor receptor binding
inferred from physical interaction with FLYBASE:Egfr; FB:FBgn0003731
(Wang and Pai, 2011)
enables phosphotyrosine residue binding
inferred from physical interaction with FLYBASE:csw; FB:FBgn0000382
(Cleghon et al., 1998)
enables protein binding
inferred from physical interaction with UniProtKB:Q9VZI2
(Schoenherr et al., 2012)
inferred from physical interaction with UniProtKB:Q9VZZ9
(Feller et al., 2002)
inferred from physical interaction with UniProtKB:P98081
(Le and Simon, 1998)
inferred from physical interaction with FLYBASE:Cbl; FB:FBgn0020224
(Wang and Pai, 2011)
inferred from physical interaction with FLYBASE:Sos; FB:FBgn0001965
(Olivier et al., 1993)
enables sevenless binding
inferred from physical interaction with FLYBASE:sev; FB:FBgn0003366
(Raabe et al., 1995, Olivier et al., 1993)
inferred from direct assay
(Almudi et al., 2010)
enables signaling receptor complex adaptor activity
inferred from physical interaction with FLYBASE:Egfr; FB:FBgn0003731
(Schweitzer et al., 1995)
inferred from physical interaction with FLYBASE:Sos; FB:FBgn0001965
(Raabe et al., 1995, Olivier et al., 1993)
inferred from physical interaction with FLYBASE:sev; FB:FBgn0003366
(Olivier et al., 1993)
inferred from physical interaction with FLYBASE:sev; FB:FBgn0003366,FLYBASE:dos; FB:FBgn0016794
(Feller et al., 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables epidermal growth factor receptor binding
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
enables phosphotyrosine residue binding
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
Biological Process (22 terms)
Terms Based on Experimental Evidence (20 terms)
CV Term
Evidence
References
involved_in associative learning
inferred from mutant phenotype
(Moressis et al., 2009)
involved_in epidermal growth factor receptor signaling pathway
inferred from mutant phenotype
(Cabernard and Affolter, 2005, Diaz-Benjumea and Hafen, 1994)
inferred from physical interaction with FLYBASE:Egfr; FB:FBgn0003731
(Schweitzer et al., 1995)
involved_in epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
involved_in fibroblast growth factor receptor signaling pathway
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
involved_in follicle cell of egg chamber development
inferred from mutant phenotype
(Jia et al., 2015)
involved_in imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Dworkin and Gibson, 2006)
involved_in insulin receptor signaling pathway
inferred from physical interaction with FLYBASE:chico; FB:FBgn0024248
(Slack et al., 2015)
involved_in olfactory learning
inferred from mutant phenotype
(Moressis et al., 2009)
involved_in positive regulation of cell size
inferred from mutant phenotype
(Sims et al., 2009)
involved_in positive regulation of ERK1 and ERK2 cascade
inferred from mutant phenotype
(Tran et al., 2013)
involved_in positive regulation of receptor-mediated endocytosis
inferred from genetic interaction with FLYBASE:Cbl; FB:FBgn0020224
(Wang and Pai, 2011)
involved_in positive regulation of TORC1 signaling
inferred from mutant phenotype
(Tran et al., 2013)
involved_in R7 cell fate commitment
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Almudi et al., 2010, Almudi et al., 2009, Simon et al., 1993)
involved_in Ras protein signal transduction
inferred from physical interaction with FLYBASE:Sos; FB:FBgn0001965
(Olivier et al., 1993)
inferred from physical interaction with UniProtKB:P00533
(Olivier et al., 1993)
involved_in sensory perception of sound
inferred from direct assay
(Li et al., 2019)
involved_in sevenless signaling pathway
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Almudi et al., 2009, Raabe et al., 1995, Olivier et al., 1993, Simon et al., 1993)
inferred from direct assay
(Almudi et al., 2010)
inferred from physical interaction with FLYBASE:Sos; FB:FBgn0001965
(Olivier et al., 1993)
inferred from physical interaction with FLYBASE:sev; FB:FBgn0003366
(Olivier et al., 1993)
involved_in short-term memory
inferred from mutant phenotype
(Moressis et al., 2009)
involved_in torso signaling pathway
inferred from genetic interaction with FLYBASE:Shc; FB:FBgn0015296,FLYBASE:dos; FB:FBgn0016794
(Luschnig et al., 2000)
inferred from mutant phenotype
(Hou et al., 1995)
inferred from direct assay
(Cleghon et al., 1998)
involved_in tracheal outgrowth, open tracheal system
inferred from mutant phenotype
(Cabernard and Affolter, 2005)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from direct assay
(Tran et al., 2013)
inferred from mutant phenotype
(Sims et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of MAPK cascade
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
involved_in signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in plasma membrane
inferred from direct assay
(Olivier et al., 1993)
located_in presynapse
inferred from direct assay
(Li et al., 2019)
part_of protein-containing complex
inferred from direct assay
(Schoenherr et al., 2012)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
part_of COP9 signalosome
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
is_active_in nucleoplasm
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN005273574
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the GRB2/sem-5/DRK family. (Q08012)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
downstream of receptor kinase (drk) encodes an adaptor protein that recognizes phosphorylated tyrosine residues of membrane receptors and triggers the Ras/Raf/MAPK pathway. drk product contributes to the regulation of cytoskeletal organization and participates in developmental and cognitive processes (associative learning, anesthesia resistant memory). [Date last reviewed: 2018-09-06]
Pathway (FlyBase)
INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
TORSO SIGNALING PATHWAY CORE COMPONENTS -
The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
SEVENLESS SIGNALING PATHWAY CORE COMPONENTS -
The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
EGFR SIGNALING PATHWAY CORE COMPONENTS -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
FGFR SIGNALING PATHWAY CORE COMPONENTS -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
PVR SIGNALING PATHWAY CORE COMPONENTS -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as sev and Ack (PubMed:22615583, PubMed:8462097, PubMed:8462098). Required for proper signaling by sevenless (PubMed:8462097, PubMed:8462098). May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex (PubMed:8462097, PubMed:8462098). Required for functional and morphological integrities of the scolopidia, sensory neurons and the antennal mechanosensory and motor center (AMMC) brain neuropil (PubMed:30610177). Required for Ack-dependent suppression of apoptosis in the eye (PubMed:22615583).
(UniProt, Q08012)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\drk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q08012)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
drk-RA
FBtr0087696
NM_057510
2744
211
drk-RB
FBtr0087695
NM_165994
1456
211
drk-RC
FBtr0087694
NM_165995
1102
211
drk-RD
FBtr0087698
NM_165996
2795
211
drk-RF
FBtr0087697
NM_165998
2577
211
Additional Transcript Data and Comments
Reported size (kB)

1.156 (longest cDNA)

(Olivier et al., 1993)

2.65 (longest cDNA)

(Simon et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
drk-PA
FBpp0086815
24.4
211
5.01
Q08012
NP_476858
AAF58368
drk-PB
FBpp0086814
24.4
211
5.01
Q08012
NP_725302
AAM68581
drk-PC
FBpp0086813
24.4
211
5.01
Q08012
NP_725303
AAM68582
drk-PD
FBpp0086817
24.4
211
5.01
Q08012
NP_725304
AAM68583
drk-PF
FBpp0086816
24.4
211
5.01
Q08012
NP_725306
AAM68585
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

211 aa isoforms: drk-PA, drk-PB, drk-PC, drk-PD, drk-PF
Additional Polypeptide Data and Comments
Reported size (kDa)

211 (aa); 24 (kD)

(Olivier et al., 1993)

211 (aa)

(Simon et al., 1993)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with autophosphorylated sev via SH2 domain and Sos, Dos and Dab via SH3 domains (PubMed:12128212, PubMed:8462097, PubMed:8462098, PubMed:9671493). Binds to tyrosine phosphorylated Dab via the SH2 domain (PubMed:9671493). Interacts with phosphorylated Ack (PubMed:22615583).

(UniProt, Q08012)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
imaginal disc
(Olivier et al., 1993)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Olivier et al., 1993)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
fat body/gonad primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic proventriculus
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
third instar larval stage
eye-antennal disc
(Olivier et al., 1993)
Additional Descriptive Data

drk transcripts are expressed strongly and uniformly in the eye-imaginal disc of 3rd instar larvae. They are also observed in other imaginal discs and in embryos.

(Olivier et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
photoreceptor neuron | presumptive
(Olivier et al., 1993)
adult stage
(Olivier et al., 1993)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye-antennal disc
(Olivier et al., 1993)
pupal stage
(Olivier et al., 1993)
adult stage
mushroom body calyx | faint | restricted
(Moressis et al., 2009)
pedunculus of adult mushroom body
(Moressis et al., 2009)
adult ellipsoid body ring neuron R4
(Moressis et al., 2009)
adult mushroom body alpha-lobe
(Moressis et al., 2009)
adult mushroom body beta-lobe
(Moressis et al., 2009)
adult antennal lobe glomerulus
(Tan et al., 2013, Moressis et al., 2009)
adult mushroom body alpha-lobe | intense
(Crittenden et al., 1998)
adult mushroom body beta-lobe | intense
(Crittenden et al., 1998)
mushroom body spur | intense
(Crittenden et al., 1998)
adult mushroom body alpha-lobe | faint
(Crittenden et al., 1998)
adult mushroom body beta-lobe | faint
(Crittenden et al., 1998)
calyx of adult mushroom body | faint
(Crittenden et al., 1998)
adult mushroom body gamma-lobe
(Moressis et al., 2009)
adult mushroom body alpha'-lobe | faint
(Moressis et al., 2009)
adult mushroom body gamma-lobe | intense
(Crittenden et al., 1998)
adult mushroom body beta'-lobe | faint
(Moressis et al., 2009)
lobe system of adult mushroom body
(Tan et al., 2013)
calyx of adult mushroom body
(Tan et al., 2013)
protocerebral bridge
(Tan et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

drk protein is strongly expressed in the mushroom body alpha, beta and gamma lobes and spur. It is weakly expressed in the mushroom body alpha and beta lobes and calyx.

(Crittenden et al., 1998)

drk protein was detected in lysates from larvae, pupae, and adults. Immunolocalization studies indicate that it is expressed at high levels in all cells of the eye-antennal disc in third instar larvae, primarily in the apical membranes. Behind the morphogenetic furrow, it is observed at higher levels in a subpopulation of developing photoreceptor cells.

(Olivier et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in nucleoplasm
inferred from high throughput direct assay
(Lye et al., 2014)
located_in plasma membrane
inferred from direct assay
(Olivier et al., 1993)
located_in presynapse
inferred from direct assay
(Li et al., 2019)
part_of protein-containing complex
inferred from direct assay
(Schoenherr et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\drk in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of drk
Transgenic constructs containing regulatory region of drk
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with drke0A)
lethal (with drkΔP24)
lethal | embryonic stage | rescuable maternal effect
lethal | larval stage | recessive
lethal | recessive
lethal - all die before end of pupal stage (with drke0A)
lethal - all die before end of pupal stage (with drkR1)
lethal - all die before end of pupal stage | recessive
partially lethal (with drk6)
partially lethal (with drkΔP24)
partially lethal - majority die (with drk6)
partially lethal - majority die (with drk14-7)
partially lethal - majority live (with drk6)
partially lethal - majority live (with drk14-7)
partially lethal - majority live (with drke0A)
partially lethal - majority live (with drkΔP24)
Other Phenotypes
Allele
abnormal gravitaxis, with Scer\GAL4elav-C155
abnormal gravitaxis (with drk6)
abnormal gravitaxis (with drk14-7)
abnormal gravitaxis | somatic clone
abnormal learning
abnormal learning, with Scer\GAL4c739
abnormal learning, with Scer\GAL4c747
abnormal learning, with Scer\GAL4Mef2.247
abnormal learning, with Scer\GAL4Tab2-201Y
abnormal memory
abnormal neuroanatomy | larval stage, with Scer\GAL4elav-C155
some die during pupal stage (with drke0A)
some die during pupal stage (with drkR1)
some die during pupal stage | recessive
visible | dominant
visible | recessive
Phenotype manifest in
Allele
abdomen | posterior
abdominal 1 lateral pentascolopidial chordotonal organ lch5
abdominal 1 ventral monoscolopidial chordotonal organ vch1
abdominal 2 lateral pentascolopidial chordotonal organ lch5
abdominal 2 ventral monoscolopidial chordotonal organ vch1
abdominal 3 lateral pentascolopidial chordotonal organ lch5
abdominal 3 ventral monoscolopidial chordotonal organ vch1
abdominal 4 lateral pentascolopidial chordotonal organ lch5
abdominal 4 ventral monoscolopidial chordotonal organ vch1
abdominal 5 lateral pentascolopidial chordotonal organ lch5
abdominal 5 ventral monoscolopidial chordotonal organ vch1
abdominal 6 lateral pentascolopidial chordotonal organ lch5
abdominal 6 ventral monoscolopidial chordotonal organ vch1
abdominal 7 lateral pentascolopidial chordotonal organ lch5
abdominal 7 ventral monoscolopidial chordotonal organ vch1
anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155
dorsal air sac primordium | somatic clone
embryonic/first instar larval cuticle
glial cell, with Scer\GAL4drl.442
glial cell, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
head
imaginal disc
larval intersegmental nerve, with Scer\GAL4elav-C155
macrochaeta
photoreceptor cell R7
scolopidium (with drk6)
scolopidium (with drk14-7)
scolopidium | somatic clone
vesicle, with Scer\GAL4drl.442
vesicle, with Scer\GAL4repo, Scer\GAL80ts.αTub84B
wing
wing | posterior
wing vein
wing vein | ectopic
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (86)
Hsap\GRB2
13 of 14
Yes
Yes
Hsap\GRAP
7 of 14
No
Yes
 
2  
Hsap\GRAP2
5 of 14
No
Yes
Hsap\GRAPL
4 of 14
No
Yes
Hsap\ABL1
2 of 14
No
No
0  
Hsap\ABL2
2 of 14
No
No
2  
Hsap\BLK
2 of 14
No
No
Hsap\BTK
2 of 14
No
No
3  
Hsap\CSK
2 of 14
No
No
1  
Hsap\FER
2 of 14
No
No
1  
Hsap\FGR
2 of 14
No
No
1  
Hsap\FRK
2 of 14
No
No
Hsap\FYN
2 of 14
No
No
3  
Hsap\HCK
2 of 14
No
No
Hsap\ITK
2 of 14
No
No
1  
Hsap\LCK
2 of 14
No
No
Hsap\LYN
2 of 14
No
No
Hsap\MATK
2 of 14
No
No
1  
Hsap\PTK6
2 of 14
No
No
Hsap\SRC
2 of 14
No
No
Hsap\SRMS
2 of 14
No
No
Hsap\TEC
2 of 14
No
No
Hsap\TXK
2 of 14
No
No
Hsap\YES1
2 of 14
No
No
Hsap\BCAR3
1 of 14
No
No
1  
Hsap\BMX
1 of 14
No
No
Hsap\CD2AP
1 of 14
No
No
5  
Hsap\CHN2
1 of 14
No
No
Hsap\CISH
1 of 14
No
No
Hsap\CRK
1 of 14
No
No
1  
Hsap\CRKL
1 of 14
No
No
2  
Hsap\DAPP1
1 of 14
No
Yes
Hsap\DNMBP
1 of 14
No
No
Hsap\FCHSD2
1 of 14
No
No
Hsap\FES
1 of 14
No
No
Hsap\GRB14
1 of 14
No
No
Hsap\INPP5D
1 of 14
No
No
1  
Hsap\INPPL1
1 of 14
No
No
Hsap\ITSN1
1 of 14
No
No
Hsap\ITSN2
1 of 14
No
No
1  
Hsap\NCK1
1 of 14
No
No
2  
Hsap\NCK2
1 of 14
No
No
Hsap\PIK3R2
1 of 14
No
No
Hsap\PIK3R3
1 of 14
No
No
Hsap\PLCG1
1 of 14
No
No
8  
Hsap\PLCG2
1 of 14
No
No
2  
Hsap\PSTPIP1
1 of 14
No
No
Hsap\PTPN6
1 of 14
No
No
3  
Hsap\PTPN11
1 of 14
No
No
7  
Hsap\RASA1
1 of 14
No
No
Hsap\SH2D1A
1 of 14
No
No
Hsap\SH2D1B
1 of 14
No
No
1  
Hsap\SH2D4B
1 of 14
No
Yes
Hsap\SH2D7
1 of 14
No
Yes
Hsap\SH3D19
1 of 14
No
No
Hsap\SH3GL2
1 of 14
No
No
4  
Hsap\SH3GL3
1 of 14
No
No
Hsap\SH3KBP1
1 of 14
No
No
1  
Hsap\SH3RF1
1 of 14
No
No
Hsap\SH3RF2
1 of 14
No
No
Hsap\SH3RF3
1 of 14
No
No
Hsap\SHB
1 of 14
No
No
Hsap\SHC1
1 of 14
No
No
1  
Hsap\SHC3
1 of 14
No
No
Hsap\SHC4
1 of 14
No
No
1  
Hsap\SHD
1 of 14
No
No
Hsap\SHE
1 of 14
No
No
Hsap\SHF
1 of 14
No
No
Hsap\SLA2
1 of 14
No
No
Hsap\SLA
1 of 14
No
Yes
Hsap\SOCS1
1 of 14
No
No
Hsap\SOCS2
1 of 14
No
No
1  
Hsap\SOCS3
1 of 14
No
No
1  
Hsap\SOCS4
1 of 14
No
No
1  
Hsap\SOCS5
1 of 14
No
No
Hsap\SOCS6
1 of 14
No
No
1  
Hsap\SOCS7
1 of 14
No
No
Hsap\SORBS1
1 of 14
No
No
Hsap\SORBS2
1 of 14
No
No
Hsap\SORBS3
1 of 14
No
No
1  
Hsap\SPTAN1
1 of 14
No
No
Hsap\SYK
1 of 14
No
No
Hsap\TNS2
1 of 14
No
No
Hsap\VAV1
1 of 14
No
No
1  
Hsap\VAV2
1 of 14
No
No
Hsap\VAV3
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (67)
Rnor\Grb2
13 of 14
Yes
Yes
Rnor\Grap
7 of 14
No
Yes
Rnor\Grap2
5 of 14
No
Yes
Rnor\Abl1
2 of 14
No
No
Rnor\Abl2
2 of 14
No
No
Rnor\Blk
2 of 14
No
No
Rnor\Csk
2 of 14
No
No
Rnor\Fer
2 of 14
No
No
Rnor\Fgr
2 of 14
No
No
Rnor\Frk
2 of 14
No
No
Rnor\Fyn
2 of 14
No
No
Rnor\Hck
2 of 14
No
No
Rnor\Lck
2 of 14
No
No
Rnor\Lyn
2 of 14
No
No
Rnor\Ptk6
2 of 14
No
No
Rnor\Src
2 of 14
No
No
Rnor\Srms
2 of 14
No
No
Rnor\Yes1
2 of 14
No
No
Rnor\Abi2
1 of 14
No
No
Rnor\Bmx
1 of 14
No
No
Rnor\Btk
1 of 14
No
No
Rnor\Cd2ap
1 of 14
No
No
Rnor\Cish
1 of 14
No
No
Rnor\Crkl
1 of 14
No
No
Rnor\Crk
1 of 14
No
No
Rnor\Dnmbp
1 of 14
No
No
Rnor\Eps8
1 of 14
No
No
Rnor\Fes
1 of 14
No
No
Rnor\Itk
1 of 14
No
No
Rnor\Itsn1
1 of 14
No
No
Rnor\Itsn2
1 of 14
No
No
Rnor\LOC100360527
1 of 14
No
Yes
Rnor\Matk
1 of 14
No
No
Rnor\Nck1
1 of 14
No
No
Rnor\Nck2
1 of 14
No
No
Rnor\Plcg1
1 of 14
No
No
Rnor\Plcg2
1 of 14
No
No
Rnor\Prmt2
1 of 14
No
No
Rnor\Rasa1
1 of 14
No
No
Rnor\Sh3d19
1 of 14
No
No
Rnor\Sh3gl1
1 of 14
No
No
Rnor\Sh3gl2
1 of 14
No
No
Rnor\Sh3gl3
1 of 14
No
No
Rnor\Sh3kbp1
1 of 14
No
No
Rnor\Shb
1 of 14
No
No
Rnor\Shc1
1 of 14
No
No
Rnor\Shc2
1 of 14
No
No
Rnor\Shd
1 of 14
No
No
Rnor\She
1 of 14
No
No
Rnor\Shf
1 of 14
No
Yes
Rnor\Sla2
1 of 14
No
Yes
Rnor\Socs1
1 of 14
No
No
Rnor\Socs2
1 of 14
No
Yes
Rnor\Socs3
1 of 14
No
No
Rnor\Socs4
1 of 14
No
No
Rnor\Socs5
1 of 14
No
No
Rnor\Socs6
1 of 14
No
No
Rnor\Socs7
1 of 14
No
No
Rnor\Sorbs2
1 of 14
No
No
Rnor\Sorbs3
1 of 14
No
No
Rnor\Syk
1 of 14
No
No
Rnor\Tec
1 of 14
No
No
Rnor\Tns2
1 of 14
No
No
Rnor\Txk
1 of 14
No
No
Rnor\Vav1
1 of 14
No
No
Rnor\Vav2
1 of 14
No
No
Rnor\Vav3
1 of 14
No
No
Mus musculus (laboratory mouse) (68)
Mmus\Grb2
12 of 14
Yes
Yes
Mmus\Grap
7 of 14
No
Yes
Mmus\Grap2
5 of 14
No
Yes
Mmus\Abl1
2 of 14
No
No
Mmus\Abl2
2 of 14
No
No
Mmus\Blk
2 of 14
No
No
Mmus\Csk
2 of 14
No
No
Mmus\Fer
2 of 14
No
No
Mmus\Fgr
2 of 14
No
No
Mmus\Frk
2 of 14
No
No
Mmus\Fyn
2 of 14
No
No
Mmus\Hck
2 of 14
No
No
Mmus\Lck
2 of 14
No
No
Mmus\Lyn
2 of 14
No
No
Mmus\Ptk6
2 of 14
No
No
Mmus\Src
2 of 14
No
No
Mmus\Srms
2 of 14
No
No
Mmus\Yes1
2 of 14
No
No
Mmus\Bmx
1 of 14
No
No
Mmus\Btk
1 of 14
No
No
Mmus\Cd2ap
1 of 14
No
No
Mmus\Cish
1 of 14
No
No
Mmus\Crkl
1 of 14
No
No
Mmus\Crk
1 of 14
No
No
Mmus\Dapp1
1 of 14
No
Yes
Mmus\Dnmbp
1 of 14
No
Yes
Mmus\Fes
1 of 14
No
No
Mmus\Itk
1 of 14
No
No
Mmus\Itsn1
1 of 14
No
No
Mmus\Itsn2
1 of 14
No
No
Mmus\Matk
1 of 14
No
No
Mmus\Nck1
1 of 14
No
No
Mmus\Nck2
1 of 14
No
No
Mmus\Pik3r3
1 of 14
No
No
Mmus\Plcg1
1 of 14
No
No
Mmus\Plcg2
1 of 14
No
No
Mmus\Prmt2
1 of 14
No
No
Mmus\Rasa1
1 of 14
No
No
Mmus\Sh3d19
1 of 14
No
No
Mmus\Sh3gl1
1 of 14
No
No
Mmus\Sh3gl2
1 of 14
No
No
Mmus\Sh3gl3
1 of 14
No
No
Mmus\Sh3kbp1
1 of 14
No
No
Mmus\Sh3rf3
1 of 14
No
No
Mmus\Shb
1 of 14
No
No
Mmus\Shc1
1 of 14
No
No
Mmus\Shc2
1 of 14
No
No
Mmus\Shd
1 of 14
No
No
Mmus\She
1 of 14
No
No
Mmus\Shf
1 of 14
No
No
Mmus\Sla2
1 of 14
No
Yes
Mmus\Socs1
1 of 14
No
No
Mmus\Socs2
1 of 14
No
No
Mmus\Socs3
1 of 14
No
No
Mmus\Socs4
1 of 14
No
No
Mmus\Socs5
1 of 14
No
No
Mmus\Socs6
1 of 14
No
No
Mmus\Socs7
1 of 14
No
No
Mmus\Sorbs1
1 of 14
No
No
Mmus\Sorbs2
1 of 14
No
No
Mmus\Sorbs3
1 of 14
No
No
Mmus\Syk
1 of 14
No
No
Mmus\Tec
1 of 14
No
No
Mmus\Tns2
1 of 14
No
No
Mmus\Txk
1 of 14
No
No
Mmus\Vav1
1 of 14
No
No
Mmus\Vav2
1 of 14
No
No
Mmus\Vav3
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (70)
Xtro\grb2
11 of 13
Yes
Yes
Xtro\grap
7 of 13
No
Yes
Xtro\grap2
4 of 13
No
Yes
Xtro\abl1
2 of 13
No
No
Xtro\abl2
2 of 13
No
No
Xtro\btk
2 of 13
No
No
Xtro\csk
2 of 13
No
No
Xtro\fer
2 of 13
No
No
Xtro\frk
2 of 13
No
No
Xtro\lck
2 of 13
No
No
Xtro\lrit2
2 of 13
No
No
Xtro\ptk6
2 of 13
No
No
Xtro\tec
2 of 13
No
No
Xtro\uqcrfs1
2 of 13
No
No
Xtro\ahi1
1 of 13
No
Yes
Xtro\bcar3
1 of 13
No
No
Xtro\cish
1 of 13
No
No
Xtro\crkl
1 of 13
No
No
Xtro\eps8l2
1 of 13
No
No
Xtro\fchsd1
1 of 13
No
No
Xtro\fchsd2
1 of 13
No
No
Xtro\fes
1 of 13
No
No
Xtro\fgr
1 of 13
No
No
Xtro\fyn
1 of 13
No
No
Xtro\gm2a
1 of 13
No
No
Xtro\grb7
1 of 13
No
Yes
Xtro\hck
1 of 13
No
No
Xtro\hsh2d
1 of 13
No
Yes
Xtro\itk
1 of 13
No
No
Xtro\itsn2
1 of 13
No
No
Xtro\LOC101733045
1 of 13
No
No
Xtro\lyn
1 of 13
No
No
Xtro\matk
1 of 13
No
No
Xtro\myo1f
1 of 13
No
No
Xtro\nck1
1 of 13
No
No
Xtro\pik3r1
1 of 13
No
No
Xtro\pik3r3
1 of 13
No
No
Xtro\ptpn11b
1 of 13
No
No
Xtro\ptpn11
1 of 13
No
No
Xtro\rasa1
1 of 13
No
No
Xtro\rbm22
1 of 13
No
No
Xtro\sfrpx
1 of 13
No
No
Xtro\sh2d1a
1 of 13
No
Yes
Xtro\sh2d4b
1 of 13
No
Yes
Xtro\sh3gl1
1 of 13
No
No
Xtro\sh3gl3
1 of 13
No
No
Xtro\sh3kbp1
1 of 13
No
No
Xtro\sh3rf1
1 of 13
No
No
Xtro\shb
1 of 13
No
No
Xtro\shc1
1 of 13
No
No
Xtro\shc2
1 of 13
No
No
Xtro\shc4
1 of 13
No
No
Xtro\she
1 of 13
No
No
Xtro\shf
1 of 13
No
No
Xtro\sla2
1 of 13
No
Yes
Xtro\sla
1 of 13
No
Yes
Xtro\sncaip
1 of 13
No
Yes
Xtro\socs1
1 of 13
No
Yes
Xtro\socs3l
1 of 13
No
No
Xtro\socs3
1 of 13
No
No
Xtro\socs4
1 of 13
No
No
Xtro\socs5
1 of 13
No
No
Xtro\socs7
1 of 13
No
No
Xtro\src
1 of 13
No
No
Xtro\tas2r39
1 of 13
No
No
Xtro\tepsin
1 of 13
No
No
Xtro\tob1
1 of 13
No
No
Xtro\XB5826631
1 of 13
No
No
Xtro\yes1
1 of 13
No
No
Xtro\zap70
1 of 13
No
No
Danio rerio (Zebrafish) (85)
Drer\grb2b
13 of 14
Yes
Yes
Drer\grb2a
12 of 14
No
Yes
Drer\grapa
7 of 14
No
Yes
Drer\grapb
7 of 14
No
Yes
Drer\grap2b
6 of 14
No
Yes
Drer\grap2a
5 of 14
No
Yes
Drer\abl1
2 of 14
No
No
Drer\abl2
2 of 14
No
No
Drer\blk
2 of 14
No
No
Drer\btk
2 of 14
No
No
Drer\csk
2 of 14
No
No
Drer\frk
2 of 14
No
No
Drer\fyna
2 of 14
No
No
Drer\fynb
2 of 14
No
No
Drer\hck
2 of 14
No
No
Drer\lck
2 of 14
No
No
Drer\matk
2 of 14
No
No
Drer\ptk6b
2 of 14
No
No
Drer\sla2a
2 of 14
No
Yes
Drer\src
2 of 14
No
No
Drer\srms
2 of 14
No
No
Drer\yes1
2 of 14
No
No
Drer\yrk
2 of 14
No
No
Drer\asap1a
1 of 14
No
No
Drer\asap1b
1 of 14
No
No
Drer\bcar3
1 of 14
No
No
Drer\cishb
1 of 14
No
No
Drer\cish
1 of 14
No
No
Drer\clnk
1 of 14
No
Yes
Drer\crk
1 of 14
No
No
Drer\crkl
1 of 14
No
No
Drer\eps8l3b
1 of 14
No
No
Drer\fer
1 of 14
No
No
Drer\fes
1 of 14
No
No
Drer\itk
1 of 14
No
No
Drer\itsn1
1 of 14
No
No
Drer\itsn2a
1 of 14
No
No
Drer\itsn2b
1 of 14
No
No
Drer\nck1a
1 of 14
No
No
Drer\nck1b
1 of 14
No
No
Drer\nck2a
1 of 14
No
No
Drer\nck2b
1 of 14
No
No
Drer\pik3r1
1 of 14
No
No
Drer\pik3r3a
1 of 14
No
No
Drer\pik3r3b
1 of 14
No
No
Drer\plcg1
1 of 14
No
No
Drer\ptk6a
1 of 14
No
No
Drer\rasa1a
1 of 14
No
No
Drer\rasa1b
1 of 14
No
No
Drer\rin3
1 of 14
No
No
Drer\sh2d3a
1 of 14
No
No
Drer\sh2d4bb
1 of 14
No
Yes
Drer\sh3d21
1 of 14
No
No
Drer\sh3gl1b
1 of 14
No
No
Drer\sh3gl2a
1 of 14
No
No
Drer\sh3gl2b
1 of 14
No
No
Drer\sh3gl3a
1 of 14
No
No
Drer\sh3kbp1
1 of 14
No
No
Drer\shc2
1 of 14
No
No
Drer\shda
1 of 14
No
No
Drer\shdb
1 of 14
No
No
Drer\she
1 of 14
No
No
Drer\si:ch73-340m8.2
1 of 14
No
No
Drer\socs1a
1 of 14
No
No
Drer\socs1b
1 of 14
No
No
Drer\socs2
1 of 14
No
No
Drer\socs3a
1 of 14
No
No
Drer\socs3b
1 of 14
No
No
Drer\socs4
1 of 14
No
No
Drer\socs5a
1 of 14
No
No
Drer\socs5b
1 of 14
No
No
Drer\socs6b
1 of 14
No
No
Drer\socs6
1 of 14
No
No
Drer\socs7
1 of 14
No
No
Drer\socs9
1 of 14
No
No
Drer\sorbs2a
1 of 14
No
No
Drer\srgap1a
1 of 14
No
No
Drer\srgap1b
1 of 14
No
No
Drer\syk
1 of 14
No
No
Drer\tec
1 of 14
No
No
Drer\tns2a
1 of 14
No
No
Drer\txk
1 of 14
No
No
Drer\vav2
1 of 14
No
No
Drer\vav3b
1 of 14
No
No
Drer\zgc:158464
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (41)
Cele\sem-5
13 of 14
Yes
Yes
Cele\abl-1
2 of 14
No
No
Cele\csk-1
2 of 14
No
No
Cele\src-1
2 of 14
No
No
Cele\src-2
2 of 14
No
No
Cele\Y47G6A.5
2 of 14
No
No
Cele\B0303.7
1 of 14
No
No
Cele\C25A8.5
1 of 14
No
No
Cele\C26C6.8
1 of 14
No
No
Cele\C35E7.10
1 of 14
No
No
Cele\C55C3.4
1 of 14
No
No
Cele\cdap-2
1 of 14
No
No
Cele\ced-2
1 of 14
No
No
Cele\F09A5.2
1 of 14
No
No
Cele\F13B12.6
1 of 14
No
Yes
Cele\F22B3.8
1 of 14
No
No
Cele\F23C8.7
1 of 14
No
No
Cele\F39B2.5
1 of 14
No
No
Cele\F57B9.8
1 of 14
No
No
Cele\F59A3.8
1 of 14
No
No
Cele\frk-1
1 of 14
No
No
Cele\itsn-1
1 of 14
No
No
Cele\kin-5
1 of 14
No
No
Cele\kin-14
1 of 14
No
No
Cele\kin-26
1 of 14
No
No
Cele\M176.9
1 of 14
No
No
Cele\nck-1
1 of 14
No
No
Cele\plc-3
1 of 14
No
No
Cele\R11E3.1
1 of 14
No
No
Cele\shc-1
1 of 14
No
No
Cele\sorb-1
1 of 14
No
No
Cele\spc-1
1 of 14
No
No
Cele\svh-2
1 of 14
No
No
Cele\T06C10.3
1 of 14
No
No
Cele\T21G5.1
1 of 14
No
No
Cele\T25B9.4
1 of 14
No
No
Cele\vav-1
1 of 14
No
No
Cele\W01B6.5
1 of 14
No
No
Cele\Y37A1B.17
1 of 14
No
Yes
Cele\Y43C5B.2
1 of 14
No
No
Cele\ZK622.1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (31)
Agam\AgaP_AGAP011768
11 of 12
Yes
Yes
Agam\AgaP_AGAP003986
2 of 12
No
No
Agam\AgaP_AGAP004989
2 of 12
No
No
Agam\AgaP_AGAP006270
2 of 12
No
No
Agam\AgaP_AGAP006510
2 of 12
No
No
Agam\AgaP_AGAP008317
2 of 12
No
No
Agam\AgaP_AGAP000880
1 of 12
No
No
Agam\AgaP_AGAP001148
1 of 12
No
No
Agam\AgaP_AGAP001259
1 of 12
No
No
Agam\AgaP_AGAP002438
1 of 12
No
No
Agam\AgaP_AGAP002493
1 of 12
No
No
Agam\AgaP_AGAP002710
1 of 12
No
No
Agam\AgaP_AGAP002729
1 of 12
No
No
Agam\AgaP_AGAP003651
1 of 12
No
No
Agam\AgaP_AGAP003735
1 of 12
No
No
Agam\AgaP_AGAP003863
1 of 12
No
No
Agam\AgaP_AGAP004211
1 of 12
No
No
Agam\AgaP_AGAP004844
1 of 12
No
No
Agam\AgaP_AGAP005616
1 of 12
No
No
Agam\AgaP_AGAP006774
1 of 12
No
No
Agam\AgaP_AGAP006893
1 of 12
No
No
Agam\AgaP_AGAP007717
1 of 12
No
No
Agam\AgaP_AGAP008273
1 of 12
No
No
Agam\AgaP_AGAP008494
1 of 12
No
No
Agam\AgaP_AGAP009037
1 of 12
No
No
Agam\AgaP_AGAP009499
1 of 12
No
No
Agam\AgaP_AGAP010135
1 of 12
No
No
Agam\AgaP_AGAP010710
1 of 12
No
No
Agam\AgaP_AGAP010886
1 of 12
No
No
Agam\AgaP_AGAP011152
1 of 12
No
No
Agam\AgaP_AGAP012240
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (9)
Atha\AT1G67890
1 of 13
Yes
No
Atha\AT3G06620
1 of 13
Yes
No
Atha\AT3G06630
1 of 13
Yes
No
Atha\AT3G06640
1 of 13
Yes
No
Atha\AT5G49470
1 of 13
Yes
No
Atha\AT5G57610
1 of 13
Yes
No
Atha\STY8
1 of 13
Yes
No
Atha\STY17
1 of 13
Yes
No
Atha\STY46
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\LSB1
2 of 13
Yes
Yes
Scer\LSB3
2 of 13
Yes
Yes
Scer\PIN3
2 of 13
Yes
Yes
Scer\RVS167
2 of 13
Yes
No
Scer\YSC84
2 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\skb5
1 of 12
Yes
Yes
Spom\SPAPJ696.02
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:drk. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (32)
Abl
2 of 13
Btk
2 of 13
CAP
2 of 13
Csk
2 of 13
dock
2 of 13
Src42A
2 of 13
Src64B
2 of 13
cindr
1 of 13
Cortactin
1 of 13
Crk
1 of 13
csw
1 of 13
Dap160
1 of 13
Dlish
1 of 13
Egfrap
1 of 13
EndoA
1 of 13
FER
1 of 13
hwt
1 of 13
l(3)05822
1 of 13
Lnk
1 of 13
metro
1 of 13
nwk
1 of 13
Pi3K21B
1 of 13
POSH
1 of 13
PVRAP
1 of 13
Shark
1 of 13
slpr
1 of 13
sl
1 of 13
Socs16D
1 of 13
Socs36E
1 of 13
Socs44A
1 of 13
spri
1 of 13
vap
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 4 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 5 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
GRB2; growth factor receptor bound protein 2
13 of 14
108355
      GRAP; GRB2 related adaptor protein
      7 of 14
      GRB2-RELATED ADAPTOR PROTEIN; GRAP
       
      GRAP2; GRB2 related adaptor protein 2
      5 of 14
      604518
          GRAPL; GRB2 related adaptor protein like
          4 of 14
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Dmel gene
              Ortholog showing functional complementation
              Supporting References
              drk
              Hsap\GRAP
              (Li et al., 2019)
              Interactions
              Summary of Physical Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please see the Physical Interaction reports below for full details
              RNA-protein
              Physical Interaction
              Assay
              References
              drk - pum
              rna three hybrid
              (Kim et al., 2012)
              protein-protein
              Physical Interaction
              Assay
              References
              drk - 14-3-3ε
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - 14-3-3ζ
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - ATPsynβ
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Ack
              anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot
              (Schoenherr et al., 2012)
              drk - Ack-like
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - C3G
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - CG1806
              experimental knowledge based
              (Guruharsha et al., 2011)
              drk - CG18659
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - CG42788
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - CG5004
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - CG5568
              experimental knowledge based
              (Guruharsha et al., 2011)
              drk - CG6769
              anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
              (Rhee et al., 2014)
              drk - Cad96Ca
              two hybrid, pull down, anti tag western blot
              (Tsarouhas et al., 2014)
              drk - Cbl
              anti bait coimmunoprecipitation, western blot, pull down, autoradiography, two hybrid
              (Wang and Pai, 2011, Robertson et al., 2000)
              drk - Cortactin
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Cyfip
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - DIP2
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Dab
              lambda phage display, autoradiography, anti tag coimmunoprecipitation, western blot, pull down, peptide massfingerprinting, anti bait coimmunoprecipitation
              (Friedman et al., 2011, Le and Simon, 1998)
              drk - Dld
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Dlst
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Egfr
              two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, pull down
              (Friedman et al., 2011, Wang and Pai, 2011, Bianco et al., 2007, MacDougall et al., 2004, Lai et al., 1995, Schweitzer et al., 1995)
              drk - Hexo1
              experimental knowledge based
              (Guruharsha et al., 2011)
              drk - Mec2
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Nin
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Pez
              anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
              (Friedman et al., 2011, Guruharsha et al., 2011)
              drk - Pi3K68D
              pull down, western blot
              (MacDougall et al., 2004)
              drk - Pkn
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Pvr
              two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
              (Friedman et al., 2011, Bianco et al., 2007, Ishimaru et al., 2004)
              drk - Raf
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - RhoGAP15B
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - RhoGAP18B
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - RhoGEF2
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Shc
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Sos
              nuclear magnetic resonance, pull down, western blot, isothermal titration calorimetry, predetermined participant, anti tag coimmunoprecipitation, peptide massfingerprinting, far western blotting, lambda phage display, autoradiography
              (Sayeesh et al., 2023, Thole et al., 2023, Sayeesh et al., 2022, Friedman et al., 2011, Le and Simon, 1998, Olivier et al., 1993)
              drk - Synj
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - Vps37B
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - cindr
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - cno
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - csw
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - dl
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - dos
              nuclear magnetic resonance, pull down, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot
              (Sayeesh et al., 2023, Sayeesh et al., 2022, Friedman et al., 2011, Feller et al., 2002)
              drk - ena
              pull down, western blot
              (Ahern-Djamali et al., 1999)
              drk - ex
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Kwon et al., 2013)
              drk - jub
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - lark
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - loco
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - mim
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - moody
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - mop
              experimental knowledge based
              (Guruharsha et al., 2011)
              drk - msn
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - pico
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - pins
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - pyd
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              drk - sav
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Kwon et al., 2013)
              drk - sev
              anti bait coimmunoprecipitation, western blot, nuclear magnetic resonance, fluorescent resonance energy transfer, fluorescence microscopy, pull down
              (Sayeesh et al., 2024, Almudi et al., 2010, Olivier et al., 1993)
              drk - shi
              anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, autoradiography
              (Friedman et al., 2011, Robertson et al., 2000)
              drk - sty
              anti tag coimmunoprecipitation, peptide massfingerprinting
              (Friedman et al., 2011)
              Summary of Genetic Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              drk
              suppressible
              Raf
              (Moressis et al., 2009)
              drk
              suppressible
              Ras85D
              (Moressis et al., 2009)
              drk
              suppressible
              Sos
              (Lu et al., 2014)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              B-H1
              suppressible
              drk
              (Hayashi et al., 1998)
              Cbl
              suppressible
              drk
              (Wang and Pai, 2011)
              csw
              suppressible
              drk
              (Oishi et al., 2006)
              csw
              enhanceable
              drk
              (Firth et al., 2000)
              CycE
              enhanceable
              drk
              (Brumby et al., 2004)
              Egfr
              suppressible
              drk
              (Read et al., 2005)
              Nab2
              enhanceable
              drk
              (Rounds et al., 2022)
              Pi3K68D
              suppressible
              drk
              (MacDougall et al., 2004)
              Ret
              suppressible
              drk
              (Read et al., 2005)
              sev::tor
              suppressible
              drk
              (Raabe et al., 1995)
              sev
              enhanceable
              drk
              (Almudi et al., 2010, Almudi et al., 2009, Simon et al., 1993)
              sl
              suppressible
              drk
              (Murillo-Maldonado et al., 2011)
              sl
              enhanceable
              drk
              (Murillo-Maldonado et al., 2011)
              Src42A
              suppressible
              drk
              (Zhang et al., 1999, Takahashi et al., 1996)
              Src64B
              suppressible
              drk
              (Cooper et al., 1996)
              svp
              enhanceable
              drk
              (Kramer et al., 1995)
              svp
              suppressible
              drk
              (Begemann et al., 1995)
              tor
              suppressible
              drk
              (Li and Li, 2003, Doyle and Bishop, 1993)
              vap
              suppressible
              drk
              (Botella et al., 2003)
              External Data
              Subunit Structure (UniProtKB)
              Interacts with autophosphorylated sev via SH2 domain and Sos, Dos and Dab via SH3 domains (PubMed:12128212, PubMed:8462097, PubMed:8462098, PubMed:9671493). Binds to tyrosine phosphorylated Dab via the SH2 domain (PubMed:9671493). Interacts with phosphorylated Ack (PubMed:22615583).
              (UniProt, Q08012 )
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              MIST (genetic) - An integrated Molecular Interaction Database
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2R
              Recombination map
              2-68
              Cytogenetic map
              50A13-50A13
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              50A13-50A13
              Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              50A12-50A14
              (BDGP Project Members, 1994-1999, Simon, 1993.6.25)
              50A12-50A14
              (determined by in situ hybridisation)
              (Spradling et al., 1999, Perrimon et al., 1996, Simon et al., 1993)
              50A-50B
              (determined by in situ hybridisation)
              (Roch et al., 1998)
              50A-50A
              (determined by in situ hybridisation)
              (Olivier et al., 1993)
              Experimentally Determined Recombination Data
              Location

              2-68

              (FlyBase, 2016)

              2-72.3

              (Comeron et al., 2012)

              2-70

              (Simon et al., 1993, Simon et al., 1991)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (27)
              Genomic Clones (23)
              cDNA Clones (129)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              Antibody Information
              Laboratory Generated Antibodies
               

              polyclonal

              (Moressis et al., 2009, Olivier et al., 1993)
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  drk affects 90 minute memory formation or stability within the mushroom bodies.

                  (Moressis et al., 2009)

                  dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                  (Kiger et al., 2003)

                  RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. S2R+ cells are unaffected.

                  (Kiger et al., 2003)

                  dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

                  (Rogers et al., 2003)

                  Abnormal eye development caused by ectopic expression of an activated form of Src64B is alleviated by dominant-negative mutations of csw or drk.

                  (Cooper et al., 1996)

                  dos functions upstream or independent of Ras85D and defines a signalling pathway that is independent of direct binding of the drk SH2/SH3 adaptor protein to the sev receptor tyrosine kinase.

                  (Raabe et al., 1996)

                  Membrane localization of Sos protein is independent of drk function.

                  (Karlovich et al., 1995)

                  A high affinity binding site for the drk SH3 domain maps to the Sos product tail. The N-terminal drk SH3 domain is primarily responsible for binding to the tail of the Sos product in vitro, and for signalling to the Ras85D product in vivo.

                  (Raabe et al., 1995)

                  Tyr2546 in the cytoplasmic tail of the sev protein is required for drk protein binding though a mutation in this site does not completely block sev function in vivo.

                  (Raabe et al., 1995)

                  Wild type drk function is essential for signaling by the sev receptor tyrosine kinase. Its biological activity correlates with binding of its SH2 domain to activated receptor tyrosine kinases and concomitant localization to the plasma membrane. In vitro, drk binds the C terminal tail of the Sos (a Ras guanine nucleotide releasing protein) gene product through the drk SH3 domain, thereby linking receptor tyrosine kinases to Ras activation.

                  (Olivier et al., 1993)

                  drk is required for photoreceptor development and is a suppressor of the Egfr phenotype to restore the eye to a nearly normal appearance.

                  (Simon et al., 1991)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: drk l(2)k13809

                  (Beaton, 1999.12.12)
                  Additional comments

                  Not allelic to shot.

                  (Gregory and Brown, 1998)

                  The vulval induction defects of C.elegans Cele\sem-5 mutants are efficiently rescued by drk, but the Soc phenotype of C.elegans Cele\sem-5 mutants is only poorly rescued by drk.

                  (Stern et al., 1993)
                  Nomenclature History
                  Source for database identify of
                  Nomenclature comments
                  Etymology
                  Synonyms and Secondary IDs (22)
                  Reported As
                  Symbol Synonym
                  24/1
                  (BDGP Project Members, 1994-1999)
                  CG6033
                  (Meadows, 2017.1.11, Schertel et al., 2013, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Rogers et al., 2003, Kraut et al., 2001, Kraut et al., 2001)
                  DRK
                  (Davidson and Wood, 2020, Freeman, 2015, Lu et al., 2014, Kosmidis et al., 2010, Slack et al., 2010, Moressis et al., 2009, Ferris et al., 2006, Sacharidou and Skoulakis, 2002, Roche, 2000, Le and Simon, 1998)
                  Drk
                  (Sayeesh et al., 2024, Sayeesh et al., 2023, Thole et al., 2023, Papagiannouli, 2022, Sayeesh et al., 2022, Sheng and Du, 2020, Zhang et al., 2020, Inoue et al., 2018, Lusk et al., 2017, Lye et al., 2014, Tutor et al., 2014, Mbodj et al., 2013, Muha and Müller, 2013, Park et al., 2013, Tran et al., 2013, Bier and Guichard, 2012, Schoenherr et al., 2012, Friedman et al., 2011, Wang and Pai, 2011, Kosmidis et al., 2010, Serio et al., 2010, Almudi et al., 2009, Bianco et al., 2007, Chang et al., 2007, Yatsenko et al., 2007, Bezsonova et al., 2005, Sundaram, 2005, Avery et al., 2004, Cork and Purugganan, 2004, Ishimaru et al., 2004, Voas and Rebay, 2004, Oldham and Hafen, 2003, Rogers et al., 2003, Rogers et al., 2003, Claeys et al., 2002, Borland et al., 2001, Dawes-Hoang and Wieschaus, 2001, Duchek et al., 2001, Kockel et al., 2001, Luzi et al., 2000, Robertson et al., 2000, Baek and Lee, 1999, den Hertog, 1999, Placzek and Skaer, 1999, Foukas et al., 1998, Hime et al., 1997, Okabe and Okano, 1997, Bonfini et al., 1996, Dominguez and Hafen, 1996, MacDougall and Waterfield, 1996, Karlovich et al., 1995, Lai et al., 1995, Schweitzer et al., 1995, Diaz-Benjumea and Hafen, 1994, Boedigheimer et al., 1993, Raabe et al., 1993)
                  Drk/Grb2
                  (Ishimaru et al., 2004, Ghabrial et al., 2003)
                  E(sev)2B
                  (Kumar and Moses, 2000, Takahashi et al., 1996, Kramer and Cagan, 1994, Simon et al., 1993, Yamamoto, 1993, Simon et al., 1992, Simon et al., 1991)
                  GRB2
                  (Bergwitz et al., 2013, Yamaguchi et al., 2006)
                  Grb-2
                  (Settle et al., 2003)
                  Grb/drk
                  (Friedman and Perrimon, 2006)
                  Grb2
                  (Sun et al., 2020, Lusk et al., 2017, Macagno et al., 2014, Muha and Müller, 2013, Yan et al., 2009, Dawes-Hoang and Wieschaus, 2001)
                  Grb2/drk
                  (Wilson and Leptin, 2000)
                  P1112
                  (Liebl, 1999)
                  Su(sev)R1
                  (Kumar and Moses, 2000)
                  crkl
                  (Kumar and Moses, 2000, Simon et al., 1992)
                  downstream of receptor kinase
                  (Bergwitz et al., 2013, Edwards et al., 2006)
                  drk
                  (He et al., 2025, Sutton et al., 2024, Zhao et al., 2023, Bourouliti and Skoulakis, 2022, Perlegos et al., 2022, Rounds et al., 2022, DeAngelis et al., 2021, Marmion et al., 2021, Aboukilila et al., 2020, Lee and Chen, 2019, Li et al., 2019, Ray et al., 2019, Muñoz-Soriano et al., 2018, Ashton-Beaucage and Therrien, 2017, Transgenic RNAi Project members, 2017-, Hoi et al., 2016, Malartre, 2016, Testa and Dworkin, 2016, Gene Disruption Project members, 2015-, Jia et al., 2015, Ashwal-Fluss et al., 2014, Gonzalez et al., 2014, Macagno et al., 2014, Taylor et al., 2014, Tsarouhas et al., 2014, Tutor et al., 2014, Bergwitz et al., 2013, Carter, 2013, de Celis et al., 2013.9.11, Kaipa et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Park et al., 2013, Schertel et al., 2013, Sopko and Perrimon, 2013, Zhang et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Kim et al., 2012, Murray et al., 2012, Dworkin et al., 2011, Friedman et al., 2011, Lee et al., 2011, Murillo-Maldonado et al., 2011, Ragab et al., 2011, Almudi et al., 2010, Fernández-Ayala et al., 2010, Debat et al., 2009, Kaufman, 2009.6.18, Li et al., 2009, Moressis et al., 2009, Oishi et al., 2009, Sims et al., 2009, Xue et al., 2009, Yan et al., 2009, Yakoby et al., 2008, Acevedo et al., 2007, Buszczak et al., 2007, Marsh et al., 2007, Zeitlinger et al., 2007, Dworkin and Gibson, 2006, Dworkin and Gibson., 2006, Oishi et al., 2006, Cabernard and Affolter, 2005, Jordan et al., 2005, Kundrotas and Karshikoff, 2004, MacDougall et al., 2004, Settle et al., 2003, Tollinger et al., 2003, Bergeret et al., 2001, Gim et al., 2001, Crittenden et al., 1998, Zhang et al., 1994)
                  l(2)10626
                  (Gregory and Brown, 1998, Perrimon et al., 1996)
                  l(2)k13809
                  (Liebl, 1999, Roch et al., 1998)
                  Name Synonyms
                  Downstream of receptor kinase
                  (Tutor et al., 2014, Murillo-Maldonado et al., 2011, Chang et al., 2008, Gim et al., 2001)
                  Enhancer of sevenless-2B
                  downstream of receptor kinase
                  (Young and Marcotte, 2017, Malartre, 2016, Cammarato et al., 2011, Moressis et al., 2009, Edwards et al., 2006, Oishi et al., 2006, Jordan et al., 2005)
                  downstream of receptor kinases
                  (Dworkin and Gibson, 2006)
                  downstream receptor kinase
                  (Li et al., 2009)
                  Secondary FlyBase IDs
                  • FBgn0021869
                  Datasets (1)
                  Study focus (1)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  • bait_protein
                  RTK-Ras-ERK_interaction_map
                  Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 170 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  PDB - An information portal to biological macromolecular structures
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                  References (317)