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FB2026_01
,
released March 12, 2026
PI3K, p60, dPI3K, Dp60, droPIK57
Please see the JBrowse view of Dmel\Pi3K21B for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
4.6, 4.1, 3.3 (northern blot)
4.6 (unknown)
The group(s) of polypeptides indicated below share identical sequence to each other.
506 (aa); 57 (kD predicted)
506 (aa); 58 (kD predicted)
The Pi3K21B adaptor protein was purified from
S2 cells as a heterodimeric complex with Pi3K92E protein. The Pi3K21B
protein sequence includes two SH2 domains but lacks the SH3 and BH domains
of mammalian adaptor counterparts. As in the mammalian adaptors, the
inter-SH2 domain is predicted to have a coiled-coil structure. The
Pi3K92E/Pi3K21B protein complex possesses lipid and protein kinase
activity when affinity purified from S2 cells.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pi3K21B using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Pi3K21B protein was detected at all stages tested. It is less abundant in third instar larvae than in pupae and adults.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Pi3K21B in JBrowse
2-0.5
2-0.0
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Pi3K21B is autonomously required for imaginal disc cells to achieve their normal adult size.
Df(2L)Pi3K21B-A/Df(2L)Pi3K21B-B, P{U2af38.gR10} mutants (null for Pi3K21B) stop growing normally early in the third larval instar. Though they continue to move and feed for approximately 20 days they grow very slowly. Larvae are transparent, have small imaginal discs and have reduced fat body. Nervous system, trachea and gut appear normal. Some form pupal cases but show no indication of pupal development. Mutant clones in the eye reveal that Pi3K21B is autonomously required for adult cells to reach their normal size.
Pi3K21B has been cloned and characterised.
Source for identity of: Pi3K21B CG2699
