FlyBase Allele Report: Dmel\Pi3K21B[GD9810]

General Information

Symbol

Dmel\Pi3K21B^GD9810

Species

D. melanogaster

Name

FlyBase ID

FBal0208068

Feature type

allele

Associated gene

Dmel\Pi3K21B

Associated Insertion(s)

Carried in Construct

P{GD9810}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9810}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9810

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Chiang et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Pi3K21B^GD9810 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9810

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Pi3K21B^GD9810, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU

(Chuang et al., 2014)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Pi3K21B^GD9810, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU

(Chuang et al., 2014)

Pi3K21B^GD9810, Scer\GAL4^GMR.PU is a non-enhancer of ommatidium phenotype of Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU

(Chuang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Pi3K21B^GD9810 does not reverse the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

(Chuang et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v33556

w¹¹¹⁸; P{GD9810}v33556/TM3

Notes on Origin

Discoverer