FlyBase Allele Report: Hsap\LRRK2[UAS.cCa]

General Information

Symbol

Hsap\LRRK2^UAS.cCa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Chuang

FlyBase ID

FBal0299624

Feature type

allele

Associated gene

Hsap\LRRK2

Associated Insertion(s)

Carried in Construct

P{UAS-LRRK2.C}

Key Links

Transgenic product class

wild_type

(Chuang et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Chuang et al., 2014)

Mutagen

in vitro construct

(Chuang et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-LRRK2.C}

Cytology

Description

UAS regulatory sequences drive expression of Hsap\LRRK2.

(Chuang et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\LRRK2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, enhanceable by foxo^UAS.cPa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, enhanceable by Akt^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, enhanceable by foxo^{S259A.UAS.cUa}, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

NOT Enhanced by

Statement

Reference

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, non-enhanceable by hep^GD1461, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, non-enhanceable by Dsor1^GD9123, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, non-enhanceable by sgg^S9A.UAS.cUa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, non-enhanceable by Pi3K21B^GD9810, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, non-enhanceable by rl^GD12910, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Suppressed by

Statement

Reference

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has visible phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Suppressor of

Statement

Reference

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Lrrk^e03680

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor of visible phenotype of hid^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of rpr^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of grim^GMR.PU

(Chuang et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, enhanceable by Akt^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, enhanceable by Akt^RNAi.UAS.cUa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, enhanceable by foxo^UAS.cPa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, enhanceable by foxo^UAS.cPa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, enhanceable by foxo^{S259A.UAS.cUa}, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, enhanceable by foxo^{S259A.UAS.cUa}, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

NOT Enhanced by

Statement

Reference

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, non-enhanceable by hep^GD1461, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, non-enhanceable by Dsor1^GD9123, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, non-enhanceable by Dsor1^GD9123, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, non-enhanceable by sgg^S9A.UAS.cUa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, non-enhanceable by sgg^S9A.UAS.cUa, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, non-enhanceable by Pi3K21B^GD9810, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, non-enhanceable by Pi3K21B^GD9810, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, non-enhanceable by rl^GD12910, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, non-enhanceable by rl^GD12910, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, non-enhanceable by hep^GD1461, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Suppressed by

Statement

Reference

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has eye phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa, Scer\GAL4^GMR.PU, grim^GMR.PU has ommatidium phenotype, suppressible by Akt^UAS.Exel, Scer\GAL4^GMR.PU

(Chuang et al., 2014)

Suppressor of

Statement

Reference

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of rpr^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor | partially of ommatidium phenotype of rpr^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of hid^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor of ommatidium phenotype of hid^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of grim^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor | partially of ommatidium phenotype of grim^GMR.PU

(Chuang et al., 2014)

Hsap\LRRK2^UAS.cCa/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Lrrk^e03680

(Chuang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\LRRK2^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PU partially suppresses the eye phenotypes seen upon expression of grim^GMR.PU.

Expression of Hsap\LRRK2^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PU partially suppresses the eye phenotypes seen upon expression of hid^GMR.PU.

Expression of Hsap\LRRK2^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PU partially suppresses the eye phenotypes seen upon expression of rpr^GMR.PU.

Expression of Hsap\LRRK2^Scer\UAS.cCa under the control of Scer\GAL4^GMR.PU rescues the reduced eye size seen in Lrrk^e03680 mutant flies.

Co-expression of Akt1^VDRC.cUa reverses the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of Akt1^{Scer\UAS.Exel} enhances the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of Pi3K21B^GD9810 does not reverse the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of rl^GD12910 does not reverse the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of hep^GD1461 does not reverse the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of Dsor1^GD9123 does not reverse the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of foxo^Scer\UAS.cPa reverses the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of foxo^{S259A.Scer\UAS.cUa} reverses the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

Co-expression of sgg^{S9A.Scer\UAS.cUa} does not reverse the suppression of the grim^GMR.PU eye phenotype seen when Hsap\LRRK2^Scer\UAS.cCa is expressed under the control of Scer\GAL4^GMR.PU.

(Chuang et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\LRRK2^Scer\UAS.cCa

Hsap\LRRK2^UAS.cCa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Chuang

Secondary FlyBase IDs

References (1)

Report Sections

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