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General Information
Symbol
Dmel\rlGD12910
Species
D. melanogaster
Name
FlyBase ID
FBal0288221
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-rolled-i
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of rlGD12910 under the control of Scer\GAL4C587 (in combination with Gal80[ts] to restrict expression to adulthood) leads to a substantial increase in the number of germline stem cells in the germinal proliferation center, as compared to controls.

Expression of rlGD12910 under the control of Scer\GAL4tj-NP1624 results in an accumulation of early germ cells in the testis. The nuclei of many cyst stem cells in the mutant gonad are positioned adjacent to hub cells (in wild type the nuclei are dispersed away from the hub), while the number of germline stem cells associated with the hub is decreased compared to wild type.

Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference
Suppressor of
Phenotype Manifest In
NOT Enhancer of
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of rlGD12910 does not reverse the suppression of the grimGMR.PU eye phenotype seen when Hsap\LRRK2Scer\UAS.cCa is expressed under the control of Scer\GAL4GMR.PU.

Expression of rlGD12910 suppresses the ectopic wing vein phenotype seen when Hsap\AUTS2Scer\UAS.T:Zzzz\FLAG is expressed under the control of Scer\GAL4nub-AC-62.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
rlGD12910
Name Synonyms
Secondary FlyBase IDs
    References (10)