FB2026_03 , released September 17, 2026
CV Term Report
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Term phosphatidylinositol 3-kinase complex, class IA ID (Ontology) GO:0005943 (Gene Ontology)
Definition A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.[ PubMed:9255069 PubMed:9759495 ]
Also Known As"1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex" ; "1-phosphatidylinositol-4-phosphate kinase, class IA complex" ; "class IA PI3K complex" (for all, see Synonyms field below)
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 phosphatidylinositol 3-kinase complex, class IA (all annotations which use CV term, excluding "NOT" statements)
     part_of | phosphatidylinositol 3-kinase complex, class IA       --
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   |__phosphatidylinositol 3-kinase complex, class I
       |__phosphatidylinositol 3-kinase complex, class IA  3 rec.
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Synonyms
  • "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex" EXACT
    "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT
    "class IA PI3K complex" EXACT
    "phosphoinositide 3-kinase complex, class IA" EXACT
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