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Ghosh, A.C., Tattikota, S.G., Liu, Y., Comjean, A., Hu, Y., Barrera, V., Ho Sui, S.J., Perrimon, N. (2020). Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity.  eLife 9(): e56969.
FlyBase ID
FBrf0247588
Publication Type
Research paper
Abstract

PDGF/VEGF ligands regulate a plethora of biological processes in multicellular organisms via autocrine, paracrine, and endocrine mechanisms. We investigated organ-specific metabolic roles of Drosophila PDGF/VEGF-like factors (Pvfs). We combine genetic approaches and single-nuclei sequencing to demonstrate that muscle-derived Pvf1 signals to the Drosophila hepatocyte-like cells/oenocytes to suppress lipid synthesis by activating the Pi3K/Akt1/TOR signaling cascade in the oenocytes. Functionally, this signaling axis regulates expansion of adipose tissue lipid stores in newly eclosed flies. Flies emerge after pupation with limited adipose tissue lipid stores and lipid level is progressively accumulated via lipid synthesis. We find that adult muscle-specific expression of pvf1 increases rapidly during this stage and that muscle-to-oenocyte Pvf1 signaling inhibits expansion of adipose tissue lipid stores as the process reaches completion. Our findings provide the first evidence in a metazoan of a PDGF/VEGF ligand acting as a myokine that regulates systemic lipid homeostasis by activating TOR in hepatocyte-like cells.

PubMed ID
PubMed Central ID
PMC7752135 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Correction: Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity.
Ghosh et al., 2021, eLife 10: e66685 [FBrf0247886]

Note

Muscle signals to the rescue.
Diaz and Reis, 2020, eLife 9: e64587 [FBrf0247760]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference