FlyBase Gene Report: Dmel\Pvf1

General Information

Symbol

Dmel\Pvf1

Species

D. melanogaster

Name

PDGF- and VEGF-related factor 1

Annotation Symbol

CG7103

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030964

Gene Model Status

Current

Stock Availability

24 publicly available

Gene Summary

PDGF- and VEGF-related factor 1 (Pvf1) encodes a PDGF- and VEGF-related factor that binds to and activates the receptor tyrosine kinase encoded by Pvr. It is involved in cell migration regulation and it has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1, Rho family small GTPases and the JNK cascade, in a context-dependent manner. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

PVF, Pvf-1, VEGF, Vegf17E, l(1)G0146

Key Links

Genomic Location

Cytogenetic map

17E1-17E1

Sequence location

X:18,832,682..18,842,901 [+]

Recombination map

1-61

RefSeq locus

NC_004354 REGION:18832682..18842901

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables heparin binding

inferred from direct assay

(Rosin et al., 2004)

enables receptor ligand activity

inferred from direct assay

(Duchek et al., 2001)

enables vascular endothelial growth factor receptor binding

inferred from physical interaction with FLYBASE:Pvr; FB:FBgn0032006

(Duchek et al., 2001)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables growth factor activity

inferred from electronic annotation with InterPro:IPR000072

(InterPro Project Members, 2004-)

enables growth factor receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN000908679

(GO Reference Genome Project, 2011-)

enables vascular endothelial growth factor receptor binding

inferred from sequence or structural similarity with UniProtKB:P15692

(Cho et al., 2002)

Biological Process (16 terms)

Terms Based on Experimental Evidence (15 terms)

CV Term

Evidence

References

involved_in anterior Malpighian tubule development

inferred from mutant phenotype

(Bunt et al., 2010)

involved_in border follicle cell migration

inferred from mutant phenotype

(Bianco et al., 2007)

involved_in dorsal closure

inferred from mutant phenotype

(Macias et al., 2004)

involved_in glial cell migration

inferred from mutant phenotype

(Learte et al., 2008)

involved_in hemocyte migration

inferred from expression pattern

(Cho et al., 2002)

inferred from genetic interaction with FLYBASE:Pvf2; FB:FBgn0031888,FLYBASE:Pvf3; FB:FBgn0085407

(Cho et al., 2002)

involved_in Malpighian tubule morphogenesis

inferred from mutant phenotype

(Bunt et al., 2010)

involved_in negative regulation of apoptotic signaling pathway

inferred from mutant phenotype

(Bilak et al., 2014)

involved_in positive regulation of border follicle cell migration

inferred from mutant phenotype

(Mathieu et al., 2007, McDonald et al., 2006, McDonald et al., 2003, Duchek et al., 2001)

inferred from genetic interaction with FLYBASE:tai; FB:FBgn0041092

(McDonald et al., 2003)

involved_in positive regulation of cell migration

inferred from mutant phenotype

(Harris et al., 2007)

involved_in positive regulation of JNK cascade

inferred from mutant phenotype

(Macias et al., 2004)

involved_in regulation of cellular response to X-ray

inferred from mutant phenotype

(Bilak et al., 2014)

involved_in salivary gland morphogenesis

inferred from mutant phenotype

(Harris et al., 2007)

involved_in vascular endothelial growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:yki; FB:FBgn0034970

(Song et al., 2019)

inferred from direct assay

(Fernández-Espartero et al., 2013, Duchek et al., 2001)

inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006

(Tsai et al., 2022)

inferred from mutant phenotype

(Ragab et al., 2011, Macias et al., 2004)

inferred from genetic interaction with FLYBASE:Pvf2; FB:FBgn0031888,FLYBASE:Pvr; FB:FBgn0032006,FLYBASE:Pvf3; FB:FBgn0085407

(Read, 2018)

inferred from genetic interaction with FLYBASE:Pvf2; FB:FBgn0031888,FLYBASE:Pvf3; FB:FBgn0085407

(Cho et al., 2002)

involved_in wound healing, spreading of cells

inferred from mutant phenotype

(Tsai et al., 2022)

involved_in wound healing, spreading of epidermal cells

inferred from mutant phenotype

(Wu et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in positive regulation of cell migration

inferred from biological aspect of ancestor with PANTHER:PTN000908679

(GO Reference Genome Project, 2011-)

involved_in positive regulation of cell population proliferation

inferred from biological aspect of ancestor with PANTHER:PTN000908679

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Rosin et al., 2004, Duchek et al., 2001)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR000072

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

PDGF- AND VEGF-RELATED FACTORS

Pathway (FlyBase)

PVR SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Pathway (FlyBase)

PVR SIGNALING PATHWAY CORE COMPONENTS -: PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).

Gene Group (FlyBase)

PDGF- AND VEGF-RELATED FACTORS -: PDGF- and VEGF-related factors bind and activate the PDGF/VEGF-receptor related receptor tyrosine kinase, Pvr. (Adapted from FBrf0221727.)

Summary (Interactive Fly)

ligands that orchestrate migratory patterns of hemocytes at the embryonic ventral midline - essential cell autonomously for proper positioning of the salivary glands - border cell migration

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pvf1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VWP6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pvf1-RA

FBtr0074640

NM_078683

1896

325

Pvf1-RB

FBtr0301667

NM_001169321

1804

314

Pvf1-RC

FBtr0343604

NM_001298486

2783

300

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pvf1-PA

FBpp0074411

35.8

325

7.02

FBpp0290881

34.5

314

5.81

FBpp0310199

32.9

300

7.54

X2JCH3

NP_001285415

AHN59885

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pvf1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pvf1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.43

Transcript Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

embryonic/larval salivary gland

(Harris et al., 2007)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Heino et al., 2001)

embryonic/larval Malpighian tubule

(Wood et al., 2006)

posterior ectoderm

(Wood et al., 2006)

embryonic/larval tracheal section

(Wood et al., 2006)

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 10 -- 12

tracheal branch primordium

(Cho et al., 2002)

embryonic stage 10 -- 15

posterior ectoderm | restricted

(Cho et al., 2002)

presumptive embryonic salivary gland

(Cho et al., 2002)

embryonic stage 11 -- 12

anal pad primordium

Comment: reported as anal pad specific anlage

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13

tracheal branch primordium | restricted

(Cho et al., 2002)

embryonic stage 13 -- 16

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

embryonic stage 13 -- 17

Malpighian tubule

(Cho et al., 2002)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

Comment: Expression is strongest in female adults and in early embryos.

(Heino et al., 2001)

Additional Descriptive Data

Pvf1 expression begins in the embryonic salivary gland in stage 12, reaches peak levels in stage 15, and persists through stage 17. Pvf1 is not expressed in the ventral midline.

(Harris et al., 2007)

Stron Pvf1 expression was observed in the tracheal cells, caudal ectoderm, Malpighian tubules, and in a posterior ectodermal ring in embryos. Expression is not observed in the ventral midline.

(Wood et al., 2006)

In stage 10 embryos, expression was detected in an ectodermal patch at the caudal margin of the germband where hemocytes enter the tail. This expression continued through stage 12 and subsequently a posterior ring of ectodermal cells expressed transcript. Transcript was also detected in the salivary glands and developing trachea. Salivary gland expression persists through stage 15. General tracheal expression persisted through stage 12. During stage 13 tracheal expression was restricted to the tips of growing ganglionic branches and the visceral branches.

(Cho et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 15

embryonic/larval salivary gland

(Harris et al., 2007)

embryonic primordium of adult salivary gland

(Harris et al., 2007)

third instar larval stage -- pupal stage

wing disc

• apical plasma membrane

(Rosin et al., 2004)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular region

inferred from direct assay

(Rosin et al., 2004, Duchek et al., 2001)

Expression Deduced from Reporters

Reporter: P{GawB}LP23

Stage

Tissue/Position (including subcellular localization)

Reference

male terminalia

(Bloomington Drosophila Stock Center, 2017)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pvf1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pvf1

View exonic expression by tissue for Dmel\Pvf1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030964

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32876/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030964

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030964

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030964

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7103

Flygut - An atlas of the Drosophila adult midgut

FBgn0030964

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Pvf1

Stages(s) 1-3
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pvf1

Transgenic constructs containing regulatory region of Pvf1

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(1)Exel7465

(Ryder, 2004.4.26)

Df(1)LP23^semil2

(Macias et al., 2004)

Df(1)shop

(Otto et al., 2018)

Gene duplicated in

Dp(1;3)DC353

(Popodi, 2010.10.8)

Dp(1;Y)W39

(Macias et al., 2004)

Inferred from location ( 25 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage

Pvf1^EP1624

partially lethal

Pvf1^EP1624

partially lethal - majority die | recessive

Pvf1^G0146

viable

Pvf1^EP1624

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Pvf1^GD3432

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

semi-fertile

Pvf1^EP1624

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

Pvf1^EP1624

increased cell death | conditional

Pvf1^MB01242

increased cell death | conditional, with Scer\GAL4^VP16.bam

Pvf1^HMS01958

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Pvf1^GD3432

some die during pupal stage

Pvf1^EP1624

wild-type, with Scer\GAL4^dpp.blk1

Pvf1^EPg11235

wild-type, with Scer\GAL4^hh-Gal4

Pvf1^EPg11235

Phenotype manifest in

Allele

adult external abdomen | dorsal

Pvf1^LP23semil1

anterior fascicle & synapse, with Scer\GAL4^elav-C155

Pvf1^EP1624

border follicle cell

Pvf1^EP1624

border follicle cell, with Scer\GAL4^slbo.2.6

border follicle cell & filopodium, with Scer\GAL4^slbo.2.6

Pvf1^EPg11235

border follicle cell | cell non-autonomous | somatic clone, with Scer\GAL4^Act5C.PI

Pvf1^UAS.cMa

border follicle cell | somatic clone, with Scer\GAL4^cb41

Pvf1^UAS.cMa

border follicle cell | somatic clone, with Scer\GAL4^slbo.2.6

Pvf1^EPg11235

border follicle cell | somatic clone, with Scer\GAL4^Tub.PU

Pvf1^EPg11235

ejaculatory bulb

embryonic anterior Malpighian tubule

Pvf1^G0146

embryonic dorsal epidermis

Pvf1^EP1624

female germline stem cell | conditional

Pvf1^MB01242

female germline stem cell | conditional, with Scer\GAL4^VP16.bam

Pvf1^HMS01958

larval intersegmental nerve, with Scer\GAL4^elav-C155

Pvf1^EP1624

male terminalia

male terminalia, with Pvf1^EPg11235, Scer\GAL4^en-e16E

Pvf1^UASp.cRb

male terminalia, with Pvf1^EPg11235, Scer\GAL4^hh-Gal4

Pvf1^UASp.cRb

male terminalia, with Pvf1^UASp.cRb, Scer\GAL4^en-e16E

Pvf1^EPg11235

male terminalia, with Pvf1^UASp.cRb, Scer\GAL4^hh-Gal4

Pvf1^EPg11235

male terminalia, with Scer\GAL4^en-e16E

Pvf1^EPg11235

male terminalia, with Scer\GAL4^hh-Gal4

Pvf1^EPg11235

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\PDGFA

7 of 14

Yes

Hsap\PDGFB

7 of 14

Yes

Hsap\PDGFC

2 of 14

Yes

Hsap\PDGFD

2 of 14

Yes

Hsap\PGF

2 of 14

Yes

Hsap\VEGFA

2 of 14

Yes

Hsap\VEGFB

2 of 14

Yes

Hsap\VEGFC

2 of 14

Yes

Hsap\VEGFD

2 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Pdgfa

6 of 14

Yes

Rnor\Pdgfb

6 of 14

Yes

Rnor\Pdgfc

2 of 14

Yes

Rnor\Pdgfd

2 of 14

Yes

Rnor\Pgf

2 of 14

Yes

Rnor\Vegfa

2 of 14

Yes

Rnor\Vegfb

2 of 14

Yes

Rnor\Vegfc

2 of 14

Yes

Rnor\Vegfd

2 of 14

Yes

Mus musculus (laboratory mouse) (9)

Mmus\Pdgfa

7 of 14

Yes

Mmus\Pdgfb

6 of 14

Yes

Mmus\Pdgfc

2 of 14

Yes

Mmus\Pdgfd

2 of 14

Yes

Mmus\Pgf

2 of 14

Yes

Mmus\Vegfa

2 of 14

Yes

Mmus\Vegfb

2 of 14

Yes

Mmus\Vegfd

2 of 14

Yes

Mmus\Vegfc

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (8)

Xtro\pdgfb

6 of 13

Yes

Xtro\pdgfa

3 of 13

Yes

Xtro\vegfa

2 of 13

Yes

Xtro\vegfd

2 of 13

Yes

Xtro\crybb1

1 of 13

Yes

Xtro\lgalsl

1 of 13

Xtro\vegfb

1 of 13

Xtro\vegfc

1 of 13

Yes

Danio rerio (Zebrafish) (15)

Drer\pdgfbb

6 of 14

Yes

Drer\pdgfaa

5 of 14

Yes

Drer\si:ch211-79m20.1

5 of 14

Yes

Drer\pdgfab

4 of 14

Yes

Drer\vegfaa

4 of 14

Yes

Drer\pdgfba

3 of 14

Yes

Drer\pgfa

3 of 14

Yes

Drer\pgfb

3 of 14

Yes

Drer\vegfab

3 of 14

Yes

Drer\vegfba

3 of 14

Yes

Drer\vegfbb

3 of 14

Yes

Drer\vegfc

2 of 14

Yes

Drer\vegfd

2 of 14

Yes

Drer\pdgfc

1 of 14

Yes

Drer\pdgfd

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\pvf-1

8 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP000574

11 of 12

Yes

Agam\AgaP_AGAP009549

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pvf1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

Pvf2

2 of 13

Pvf3

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PDGFB; platelet derived growth factor subunit B

model of basal ganglia calcification

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 5 )

Allele

Disease

Interaction

References

Pvf1^UASp.cRb

exacerbates cancer

modeled by upd3^UAS.cUa

(Ding et al., 2021)

Pvf1^KK112211

ameliorates intestinal cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Xu et al., 2024)

Pvf1^NIG.7103R

ameliorates cancer

modeled by Ras85D^V12.cUa.UAS, dlg1^RNAi.UAS.cUa

(Lodge et al., 2021)

Pvf1^d06222

ameliorates Huntington's disease

modeled by Hsap\HTT^NT.128Q.UAS

(Lu et al., 2013)

Pvf1^KG01713

exacerbates Huntington's disease

modeled by Hsap\HTT^NT.128Q.UAS

(Lu et al., 2013)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PDGFA; platelet derived growth factor subunit A

7 of 14

173430

PDGFB; platelet derived growth factor subunit B

7 of 14

190040

basal ganglia calcification

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Pvf1 - Atg8a

experimental knowledge based

(Guruharsha et al., 2011)

Pvf1 - Pvr

affinity technology, inferred by author

(Duchek et al., 2001)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pvf1

enhanceable

Egfr

(Poukkula et al., 2011)

Pvf1

enhanceable

hep

(Mathieu et al., 2007)

Pvf1

enhanceable

Pvr

(Fulga and Rorth, 2002, Duchek et al., 2001)

Pvf1

enhanceable

tai

(McDonald et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

E2f1

suppressible

Pvf1

(Bilak et al., 2014)

Egfr

enhanceable

Pvf1

(Poukkula et al., 2011, Duchek et al., 2001)

Ets21C

suppressible

Pvf1

(Mundorf et al., 2019)

kay

suppressible

Pvf1

(Franciscovich et al., 2008)

Pvr

enhanceable

Pvf1

(Rosin et al., 2004, Fulga and Rorth, 2002)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59185

DroID - A comprehensive database of gene and protein interactions.

FBgn0030964

MIST (genetic) - An integrated Molecular Interaction Database

32876

MIST (protein-protein) - An integrated Molecular Interaction Database

32876

Pathways

Signaling Pathways (FlyBase)

PVR SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-61

Cytogenetic map

17E1-17E1

Sequence location

X:18,832,682..18,842,901 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

17E1-17E1

Limits computationally determined from genome sequence between P{EP}EP1597 and P{EP}Pvf1^EP1624

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

17E-17E

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.12.14)

17E1-17E2

(Roos, 2000.7.19)

Experimentally Determined Recombination Data

Location

1-61

(FlyBase, 2016)

1-60.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (24)

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (108)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD28763

Other clones

DPiM_LD28763

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030964

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030964

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Rosin et al., 2004)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Pvf1 has a role in controlling the embryonic migration of blood cells.

(Cho et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: Pvf1 l(1)G0146

(Peter et al., 2002)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Pvf1 CG7103

(Rorth and Roos, 2001.8.16)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG7103

(Hosono et al., 2015, Lu et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Cho et al., 2002, Munier et al., 2002, Peter et al., 2002)

DmVEGF-1

(Heino et al., 2001)

EP1624

PVF

(Mishra et al., 2021, Friedman and Perrimon, 2006, Meller et al., 2005, Starz-Gaiano and Montell, 2004, Reif and Cyster, 2002)

PVF1

(Diaz et al., 2025, George et al., 2025, Dai et al., 2020, Lan et al., 2020, Richardson and Portela, 2018, Sopko and Perrimon, 2013, Hidalgo et al., 2011, Bunt et al., 2007, McDonald et al., 2006, Montell, 2006, McDonald et al., 2004, Starz-Gaiano and Montell, 2004, Duchek and Rorth, 2002, Rorth, 2002, Rosin et al., 2002)

PVFs

(Ribeiro et al., 2003)

Pvf

(Sims et al., 2009)

Pvf-1

(Neves et al., 2016, Gold and Brückner, 2015)

Pvf1

(Cruz et al., 2026, Hu et al., 2026, Cheng et al., 2025, Lee and Kwon, 2025, Medina et al., 2025, Scopelliti et al., 2025, Balakireva et al., 2024, Li et al., 2024, Luo et al., 2024, Meyer et al., 2024, Saez-Carrion et al., 2024, Floc'hlay et al., 2023, Xu et al., 2023, Baonza et al., 2022, Kharrat et al., 2022, Koranteng et al., 2022, Kubrak et al., 2022, Alvarez-Ochoa et al., 2021, Bilder et al., 2021, Cox et al., 2021, Csordás et al., 2021, DeAngelis et al., 2021, Dillard et al., 2021, Ding et al., 2021, García-López et al., 2021, Lodge et al., 2021, Millet-Boureima et al., 2021, Morin-Poulard et al., 2021, Pan and O'Connor, 2021, Pang et al., 2021, Parra-Peralbo et al., 2021, Bakshi and Joshi, 2020, Kurihara et al., 2020, Luo et al., 2020, Zhou et al., 2020, Mele and Johnson, 2019, Nixon et al., 2019, Saavedra and Perrimon, 2019, Sanchez et al., 2019, Song et al., 2019, Tudrej et al., 2019, Gene Disruption Project members, 2018-, Read, 2018, Stuelten et al., 2018, Tsai et al., 2018, Transgenic RNAi Project members, 2017-, Wang et al., 2017, Parsons and Foley, 2016, Toggweiler et al., 2016, Vanha-Aho et al., 2016, Doggett et al., 2015, Ratheesh et al., 2015, Sansone et al., 2015, Shaukat et al., 2015, Su, 2015, Xing et al., 2015, Bilak et al., 2014, Evans et al., 2014, Tsuzuki et al., 2014, Lu et al., 2013, Mbodj et al., 2013, Morin-Poulard et al., 2013, Zhang et al., 2013, Amoyel and Bach, 2012, Chakrabarti et al., 2012, Inaki et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kelsey et al., 2012, Rynes et al., 2012, Poukkula et al., 2011, Janssens et al., 2010, Popodi, 2010.10.8, Wasbrough et al., 2010, Hill-Burns and Clark, 2009, Sims et al., 2009, Witsell et al., 2009, Wu et al., 2009, Brandt and Corces, 2008, Franciscovich et al., 2008, Bianco et al., 2007, Harris et al., 2007, Mathieu et al., 2007, Zeitlinger et al., 2007, Legube et al., 2006, Wood et al., 2006, Jekely et al., 2005, Macias et al., 2004, Munier et al., 2002)

VEGF

(Zeitouni et al., 2007, Traver and Zon, 2002)

VEGF2-B

(Cho, 2002.2.19)

VEGFA

(Mickael et al., 2021)

Vegf17E

(Cho et al., 2002, Cho et al., 2002)

Vegf17e-a

(Carroll, 2002.2.19)

Vegf17e-b

(Cho, 2002.2.19)

l(1)G0146

(Schäfer et al., 1999.12.14)

pvf1

(Destalminil-Letourneau et al., 2021, Gan et al., 2021, Dai et al., 2020, Ghosh et al., 2020, Mundorf et al., 2019, Xu et al., 2017, Álvarez-Fernández et al., 2015, Parsons and Foley, 2013, Weavers and Skaer, 2013, Zhang et al., 2013, Bunt et al., 2010, Learte et al., 2008, McDonald et al., 2003)

vegf1

(Li and White, 2003)

Name Synonyms

PDGF (platelet-derived growth factor)- and VEGF (vascular endothelial growth factor)-related factor 1

(Montell, 2006)

PDGF- and VEGF-related factor 1

Secondary FlyBase IDs

FBgn0029073
FBgn0044470

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32876

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VWP6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VWP6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030964

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32876/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030964

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030964

FlyMine - An integrated database for Drosophila genomics

FBgn0030964

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7103

MARRVEL_MODEL - MARRVEL (model organism gene)

32876

Linkouts

BioGRID - A database of protein and genetic interactions.

59185

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030964

DroID - A comprehensive database of gene and protein interactions.

FBgn0030964

DRSC - Results frm RNAi screens

FBgn0030964

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pvf1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030964

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030964

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7103

Flygut - An atlas of the Drosophila adult midgut

FBgn0030964

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0030964

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007448

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

32876

MIST (protein-protein) - An integrated Molecular Interaction Database

32876

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (209)

The following external sites may use different assemblies or annotations than FlyBase.

0.43

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