FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ets21C
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General Information
Symbol
Dmel\Ets21C
Species
D. melanogaster
Name
Ets at 21C
Annotation Symbol
CG2914
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005660
Gene Model Status
Current
Stock Availability
24 publicly available
Gene Summary
Ets at 21C (Ets21C) encodes a stress-inducible transcription factor that binds specifically to purine-rich DNA motifs. It cooperates with transcription factors acting downstream of the MAP kinase pathways to fine tune gene expression in response to stress, such as infection or oncogene activation. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

D-ets-6

Key Links
Genomic Location
Cytogenetic map
21E2-21E2
Sequence location
Recombination map
2-1.5
RefSeq locus
NT_033779 REGION:544925..552923
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR000418, InterPro:IPR046328
(InterPro Project Members, 2004-)
enables sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR000418
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR000418, InterPro:IPR003118
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in defense response to bacterium
inferred from mutant phenotype
(Ayres et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR000418
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR046328
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000218930
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ETS family. (P29776)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Ets at 21C (Ets21C) encodes a stress-inducible transcription factor that binds specifically to purine-rich DNA motifs. It cooperates with transcription factors acting downstream of the MAP kinase pathways to fine tune gene expression in response to stress, such as infection or oncogene activation. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
ETS DOMAIN TRANSCRIPTION FACTORS -
The E26 transformation specific (ETS) domain transcription factors are sequence-specific DNA-binding proteins that regulate transcription. These factors are characterized by a conserved 85 amino acid DNA binding ETS domain that binds specifically to purine-rich DNA motif GGAA/T. (Adapted from PMID:11715049 and PMID:9570133).
Summary (Interactive Fly)

stress-induced transcription factor - controls intestinal stem cell proliferation & enterocyte apoptosis through distinct sets of target genes - loss of function prevents epithelial aging - ectopic expression increases tumor size - expression is regulated by the JNK pathway - Capicua represses cell proliferation via direct targets including Ets21C

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Ets21C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P29776)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.53

Antisense UTR: extended 3' UTR of alternative transcript isoform of this gene overlaps nAcRbeta-21C on the opposite strand.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ets21C-RA
FBtr0078079
NM_078721
2423
475
Ets21C-RB
FBtr0112854
NM_001103577
1603
305
Ets21C-RC
FBtr0344014
NM_001298618
4461
475
Ets21C-RD
FBtr0345429
NM_001298619
2892
475
Additional Transcript Data and Comments
Reported size (kB)

2.5, 0.85 (northern blot)

(Chen et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ets21C-PA
FBpp0077739
51.8
475
9.29
P29776
NP_523445
AAF51484
Ets21C-PB
FBpp0111767
33.5
305
9.24
A8DYS7
NP_001097047
ABV53596
Ets21C-PC
FBpp0310465
51.8
475
9.29
P29776
NP_001285547
AHN54062
Ets21C-PD
FBpp0311554
51.8
475
9.29
P29776
NP_001285548
AHN54063
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

475 aa isoforms: Ets21C-PA, Ets21C-PC, Ets21C-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ets21C using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.79

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval ventral nerve cord | restricted
(Chen et al., 1992)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 10
organism | ubiquitous
(Chen et al., 1992)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
pars intercerebralis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 15
embryonic ventral nerve cord | segmentally repeated
(Chen et al., 1992)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
organism
(Chen et al., 1992)
Additional Descriptive Data

0.85kb Ets21C transcripts are expressed at approximately equal levels throughout development. The 2.5kb transcripts are detected in larval and mid pupal stages. Ets21C transcripts are expressed throughout the embryo during germ band extension. During germ band retraction, expression becomes increasingly restricted to the ventral nerve cord. Expression is higher in one pair of neurons in each thoracic segment than in the abdominal segments

(Chen et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Dorus et al., 2006)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ets21C in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ets21C
Transgenic constructs containing regulatory region of Ets21C
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene partially disrupted in
Df(2L)ΔEts21C-21
(Toggweiler et al., 2016)
Df(2L)nAChRβ3attP
(Rao and Deng, 2019.10.23)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal aging | adult stage
abnormal aging | adult stage, with Scer\GAL4esg.PU
abnormal aging | adult stage, with Scer\GAL4NP0001
abnormal cell death | adult stage, with Scer\GAL4NP0001
abnormal cell number | adult stage, with Scer\GAL4NP0001
abnormal immune response | adult stage, with Scer\GAL4NP5130
abnormal oxidative stress response | adult stage
abnormal oxidative stress response | adult stage, with Scer\GAL4esg.PU
abnormal oxidative stress response | adult stage, with Scer\GAL4NP0001
abnormal oxidative stress response | adult stage | female limited, with Scer\GAL4esg.PU
abnormal oxidative stress response | adult stage | female limited, with Scer\GAL4NP0001
abnormal stress response | adult stage
abnormal wound healing | RU486 conditional, with Scer\GAL4repo.Switch.2301
decreased occurrence of cell division | adult stage, with Scer\GAL4esg.PU
increased mortality | RU486 conditional, with Scer\GAL4repo.Switch.2301
increased occurrence of cell division | adult stage, with Scer\GAL4Delta.PU
increased occurrence of cell division | adult stage, with Scer\GAL4esg.PU
increased occurrence of cell division | adult stage, with Scer\GAL4NP0001
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
long lived
short lived, with Scer\GAL4da.Switch.PT
visible, with Scer\GAL4Bx-MS1096
visible | adult stage
Phenotype manifest in
Allele
adult midgut, with Scer\GAL4Delta.PU
adult midgut, with Scer\GAL4NP5130
adult midgut enterocyte, with Scer\GAL4NP0001
adult midgut epithelium
adult midgut epithelium, with Scer\GAL4esg.PU
adult midgut epithelium, with Scer\GAL4NP0001
adult posterior midgut, with Scer\GAL4NP0001
enteroblast, with Scer\GAL4NP0001
intestinal stem cell, with Scer\GAL4esg.PU
intestinal stem cell, with Scer\GAL4NP0001
intestinal stem cell | adult stage, with Scer\GAL4Delta.PU
intestinal stem cell | adult stage, with Scer\GAL4NP5130
wing
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (29)
Hsap\ERG
6 of 14
Yes
No
1  
Hsap\FLI1
6 of 14
Yes
No
1  
Hsap\FEV
3 of 14
No
Yes
0  
Hsap\ELK3
2 of 14
No
Yes
Hsap\ELK4
2 of 14
No
Yes
Hsap\ERF
2 of 14
No
Yes
Hsap\ETS1
2 of 14
No
No
2  
Hsap\ETV1
2 of 14
No
No
1  
Hsap\ETV2
2 of 14
No
No
Hsap\ETV3
2 of 14
No
Yes
Hsap\ETV3L
2 of 14
No
Yes
Hsap\ETV4
2 of 14
No
No
Hsap\ETV5
2 of 14
No
No
Hsap\GABPA
2 of 14
No
No
Hsap\EHF
1 of 14
No
No
Hsap\ELF1
1 of 14
No
No
1  
Hsap\ELF2
1 of 14
No
No
Hsap\ELF3
1 of 14
No
Yes
Hsap\ELF4
1 of 14
No
No
1  
Hsap\ELF5
1 of 14
No
No
Hsap\ELK1
1 of 14
No
No
2  
Hsap\ERFL
1 of 14
No
Yes
Hsap\ETS2
1 of 14
No
No
Hsap\ETV6
1 of 14
No
No
1  
Hsap\ETV7
1 of 14
No
No
1  
Hsap\SPDEF
1 of 14
No
No
Hsap\SPI1
1 of 14
No
No
Hsap\SPIB
1 of 14
No
No
Hsap\SPIC
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (27)
Rnor\Fli1
6 of 14
Yes
No
Rnor\Erg
5 of 14
No
No
Rnor\Elk1
2 of 14
No
No
Rnor\Elk3
2 of 14
No
Yes
Rnor\Elk4
2 of 14
No
Yes
Rnor\Erf
2 of 14
No
Yes
Rnor\Ets1
2 of 14
No
No
Rnor\Ets2
2 of 14
No
No
Rnor\Etv1
2 of 14
No
No
Rnor\Etv2
2 of 14
No
No
Rnor\Etv3l
2 of 14
No
Yes
Rnor\Etv3
2 of 14
No
Yes
Rnor\Etv4
2 of 14
No
No
Rnor\Etv5
2 of 14
No
No
Rnor\Fev
2 of 14
No
Yes
Rnor\Ehf
1 of 14
No
No
Rnor\Elf1
1 of 14
No
No
Rnor\Elf2
1 of 14
No
No
Rnor\Elf3
1 of 14
No
No
Rnor\Elf4
1 of 14
No
No
Rnor\Elf5
1 of 14
No
No
Rnor\Etv6
1 of 14
No
No
Rnor\Gabpa
1 of 14
No
No
Rnor\Spdef
1 of 14
No
No
Rnor\Spi1
1 of 14
No
No
Rnor\Spib
1 of 14
No
No
Rnor\Spic
1 of 14
No
No
Mus musculus (laboratory mouse) (28)
Mmus\Fli1
6 of 14
Yes
No
Mmus\Erg
5 of 14
No
No
Mmus\Elk1
2 of 14
No
No
Mmus\Elk3
2 of 14
No
Yes
Mmus\Erf
2 of 14
No
Yes
Mmus\Ets1
2 of 14
No
No
Mmus\Ets2
2 of 14
No
No
Mmus\Etv1
2 of 14
No
No
Mmus\Etv2
2 of 14
No
No
Mmus\Etv3
2 of 14
No
Yes
Mmus\Etv4
2 of 14
No
No
Mmus\Etv5
2 of 14
No
No
Mmus\Fev
2 of 14
No
Yes
Mmus\Gabpa
2 of 14
No
No
Mmus\Ehf
1 of 14
No
No
Mmus\Elf1
1 of 14
No
No
Mmus\Elf2
1 of 14
No
No
Mmus\Elf3
1 of 14
No
No
Mmus\Elf4
1 of 14
No
No
Mmus\Elf5
1 of 14
No
No
Mmus\Elk4
1 of 14
No
Yes
Mmus\Erfl
1 of 14
No
Yes
Mmus\Etv3l
1 of 14
No
Yes
Mmus\Etv6
1 of 14
No
No
Mmus\Spdef
1 of 14
No
No
Mmus\Spi1
1 of 14
No
No
Mmus\Spib
1 of 14
No
No
Mmus\Spic
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (18)
Xtro\erg
5 of 13
Yes
No
Xtro\fli1
5 of 13
Yes
No
Xtro\fev
2 of 13
No
Yes
Xtro\ankfn1l
1 of 13
No
No
Xtro\ehf
1 of 13
No
Yes
Xtro\elf1
1 of 13
No
No
Xtro\elf2
1 of 13
No
No
Xtro\elf5
1 of 13
No
Yes
Xtro\elk4
1 of 13
No
Yes
Xtro\ets1
1 of 13
No
No
Xtro\ets2
1 of 13
No
No
Xtro\etv3l
1 of 13
No
Yes
Xtro\etv3
1 of 13
No
Yes
Xtro\etv6
1 of 13
No
No
Xtro\gabpa
1 of 13
No
No
Xtro\LOC100495385
1 of 13
No
No
Xtro\psme3ip1
1 of 13
No
No
Xtro\saxo2
1 of 13
No
No
Danio rerio (Zebrafish) (29)
Drer\erg
5 of 14
Yes
No
Drer\fli1
5 of 14
Yes
No
Drer\fli1rs
4 of 14
No
No
Drer\fev
3 of 14
No
Yes
Drer\elk1
2 of 14
No
No
Drer\elk3
2 of 14
No
Yes
Drer\elk4
2 of 14
No
Yes
Drer\erf
2 of 14
No
Yes
Drer\erfl3
2 of 14
No
Yes
Drer\etsrp
2 of 14
No
No
Drer\etv4
2 of 14
No
No
Drer\etv5a
2 of 14
No
No
Drer\gabpa
2 of 14
No
No
Drer\ehf
1 of 14
No
No
Drer\elf1
1 of 14
No
No
Drer\elf2a
1 of 14
No
No
Drer\elf2b
1 of 14
No
No
Drer\elf3
1 of 14
No
Yes
Drer\erfl1
1 of 14
No
Yes
Drer\ets2
1 of 14
No
No
Drer\etv1
1 of 14
No
No
Drer\etv5b
1 of 14
No
No
Drer\etv7
1 of 14
No
No
Drer\LOC100537796
1 of 14
No
Yes
Drer\spdef
1 of 14
No
No
Drer\spi1a
1 of 14
No
No
Drer\spi1b
1 of 14
No
No
Drer\spi2
1 of 14
No
No
Drer\spic
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\ast-1
3 of 14
Yes
No
Cele\ets-5
3 of 14
Yes
No
Cele\elf-1
2 of 14
No
No
Cele\ets-7
2 of 14
No
Yes
Cele\ets-8
2 of 14
No
No
Cele\F19F10.1
2 of 14
No
Yes
Cele\C52B9.19
1 of 14
No
Yes
Cele\elk-2
1 of 14
No
Yes
Cele\ets-4
1 of 14
No
No
Cele\ets-9
1 of 14
No
Yes
Cele\lin-1
1 of 14
No
Yes
Cele\svh-5
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (7)
Agam\AgaP_AGAP009494
10 of 12
Yes
Yes
Agam\AgaP_AGAP004337
2 of 12
No
No
Agam\AgaP_AGAP004619
2 of 12
No
No
Agam\AgaP_AGAP005755
2 of 12
No
No
Agam\AgaP_AGAP009513
2 of 12
No
No
Agam\AgaP_AGAP007327
1 of 12
No
No
Agam\AgaP_AGAP009350
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ets21C. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
pnt
5 of 13
Ets65A
4 of 13
Ets96B
4 of 13
Ets97D
4 of 13
aop
3 of 13
Eip74EF
3 of 13
Ets98B
3 of 13
edl
1 of 13
Pbp49
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 5 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ERG; ETS transcription factor ERG
    6 of 14
    165080
       
      FLI1; Fli-1 proto-oncogene, ETS transcription factor
      6 of 14
      193067
         
        FEV; FEV transcription factor, ETS family member
        3 of 14
        607150
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Ras85D|Ets21C
            suppressible
            bsk
            (Külshammer et al., 2015)
            Ets21C
            suppressible
            Eip93F
            (Mundorf et al., 2019)
            Ras85D|scrib|Ets21C
            suppressible
            ftz-f1
            (Külshammer et al., 2015)
            Ets21C
            suppressible
            Imp
            (Mundorf et al., 2019)
            Ras85D|scrib|Ets21C
            suppressible
            kay
            (Külshammer et al., 2015)
            Ets21C
            suppressible
            Pvf1
            (Mundorf et al., 2019)
            Ets21C
            suppressible
            upd3
            (Mundorf et al., 2019)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            hep
            suppressible
            Ets21C
            (Mundorf et al., 2019)
            Ras85D|scrib
            suppressible
            Ets21C|kay
            (Katheder et al., 2017)
            Ras85D|scrib
            suppressible
            Ets21C
            (Külshammer et al., 2015)
            Ras85D|scrib|ftz-f1
            suppressible
            Ets21C
            (Külshammer et al., 2015)
            Ras85D|scrib|kay
            suppressible
            Ets21C
            (Külshammer et al., 2015)
            SH3PX1
            suppressible
            Ets21C
            (Zhang et al., 2019)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-1.5
            Cytogenetic map
            21E2-21E2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            21E2-21E2
            Limits computationally determined from genome sequence between P{lacW}l(2)k09610k09610&P{lacW}Sk09538a and P{PZ}l(2)1068510685&P{lacW}Tango14k00619
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            21C-21C
            (determined by in situ hybridisation)
            (Chen et al., 1992)
            Experimentally Determined Recombination Data
            Location

            2-1.5

            (FlyBase, 2016)

            2-0.2

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (24)
            Genomic Clones (18)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (5)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

                (Liu and Lehmann, 2008)

                dsRNA has been made from templates generated with primers directed against this gene. RNAi of Ets21C results in reduced arborization of ddaD and ddaE neurons and defects in dendrite morphogenesis.

                (Parrish et al., 2006)

                Ets21C has been cloned, sequenced and its RNA expression pattern characterised.

                (Chen et al., 1992)
                Relationship to Other Genes
                Source for database merge of
                Additional comments
                Nomenclature History
                Source for database identify of

                Source for identity of: Ets21C CG2914

                (Guan, 1999.11)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (12)
                Reported As
                Symbol Synonym
                CG2914
                (National Institute of Genetics Fly Stocks, 2022-, Palu and Thummel, 2016, Chambers et al., 2012, Ni et al., 2010.12.1, Baltzer et al., 2009, Keleman et al., 2009.8.5, Ayres et al., 2008)
                D-Ets-6
                (Chen et al., 1992)
                D-Ets6
                (Craig and Bateman, 2007)
                D-ets-6
                (Hsu and Schulz, 2000, Chen, 1999.9.28)
                ETS6
                (Wasylyk et al., 1993)
                Ets
                (Guruharsha et al., 2004)
                Ets21C
                (Martinez, 2025, Soffers et al., 2025, Camilleri-Robles et al., 2024, Jans et al., 2024, Meyer et al., 2024, Nigg et al., 2024, Sanderson et al., 2024, Taylor et al., 2024, Zhou et al., 2024, Bharti et al., 2023, Floc'hlay et al., 2023, Kuyateh and Obbard, 2023, Zane et al., 2023, Ding et al., 2022, Logeay et al., 2022, Waring et al., 2022, Yan et al., 2022, Zhang et al., 2022, Ahmed-Braimah et al., 2021, Ai et al., 2020, Hung et al., 2020, La Marca and Richardson, 2020, Rao and Deng, 2019.10.23, Ray et al., 2019, Shokri et al., 2019, Si et al., 2019, Zhang et al., 2019, Bischof et al., 2018, La Fortezza et al., 2018, Rajpurohit et al., 2018, Sriskanthadevan-Pirahas et al., 2018, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Jones et al., 2016, Sarov et al., 2016, Toggweiler et al., 2016, Jin et al., 2015, Katsuyama et al., 2015, Schertel et al., 2015, Short and Lazzaro, 2013, Spokony and White, 2012.5.22, Blanco et al., 2010, Radyuk et al., 2010, Baltzer et al., 2009, Lee et al., 2008, Liu and Lehmann, 2008, Copley et al., 2007, Dorus et al., 2006, Parrish et al., 2006, Johansson et al., 2005, Wang et al., 2004, Pickeral et al., 2000)
                Ets21c
                (Josserand et al., 2023, Boumard and Bardin, 2021, Gan et al., 2021, Herrera and Bach, 2021)
                Ets6
                ets21C
                (Radyuk et al., 2010, Baltzer et al., 2009, Ayres et al., 2008)
                ets21c
                (Brutscher et al., 2025, Mundorf et al., 2019, Külshammer et al., 2015, Chambers et al., 2012, Casso et al., 2005, Park et al., 2004)
                Name Synonyms
                Ets at 21C
                Secondary FlyBase IDs
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 47 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (121)