FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ets21CKK103211
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General Information
Symbol
Dmel\Ets21CKK103211
Species
D. melanogaster
Name
FlyBase ID
FBal0232230
Feature type
allele
Associated gene
Dmel\Ets21C
Associated Insertion(s)
Carried in Construct
P{KK103211}
Also Known As
UAS-Ets21C-RNAi, UAS-ets21cRNAi, KK103211
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK103211}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK103211
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  colorectal cancer
      modeled by SH3PX1JF02730
      (Zhang et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ets21CKK103211 under the control of Scer\GAL4esg.PU, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, prevents the increased cell division seen in controls in response to oxidative stress (paraquat) and significantly reduces survival of females, but not males, under these conditions; expression under normal conditions significantly reduces intestinal stem cell division and reduces epithelial turnover, compared to controls, with no loss of precursor cells, and suppresses aging-induced effects in the guts of older flies such as precursor cell accumulation and dysplasia, compared to controls.

      Expression of Ets21CKK103211 under the control of Scer\GAL4NP0001, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, prevents the elimination of enterocytes seen in controls in response to oxidative stress (paraquat) and significantly reduces survival of females, but not males, under these conditions; expression under normal conditions prevents aging-associated loss of enterocytes and gut remodelling in older flies, compared to controls; in 10 day old flies, the posterior midgut is significantly reduced in diameter and there are fewer apoptotic enterocytes, compared to controls.

      (Mundorf et al., 2019)

      Expression of Ets21CKK103211 RNAi under the control of Scer\GAL4esg-NP5130 (using tub-Gal80[ts] to limit the time of RNAi expression) results in a suppression of regeneration-associated proliferation of intestinal stem cells in the adult midgut upon Pseudomonas entomophila enteric infection.

      (Jin et al., 2015)

      Expression of Ets21CKK103211 under the control of Scer\GAL4Act.PU in clones in the eye-antennal disc does not result in any significant defect in differences in number or morphology of clones, eye-antennal disc morphology, photoreceptor differentiation, or adult eye development, as compared to controls.

      (Külshammer et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Suppressor of
      Statement
      Reference

      Ets21CKK103211, Scer\GAL4esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4esg.PU, hepUAS.cBa

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4esg.PU is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4esg.PU, hepUAS.cBa

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4NP0001 is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4NP0001, hepUAS.cBa

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4NP0001 is a suppressor of abnormal cell number | adult stage phenotype of Scer\GAL4NP0001, hepUAS.cBa

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of SH3PX1JF02730, Scer\GAL4esg.PU

      (Zhang et al., 2019)

      Ets21CKK103211, Scer\GAL4Act.PU is a suppressor | partially | somatic clone of majority die during third instar larval stage | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, scrib1

      (Külshammer et al., 2015)

      Ets21CKK103211, Scer\GAL4Act.PU is a suppressor | partially | somatic clone of abnormal developmental rate | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, scrib1

      (Külshammer et al., 2015)

      Ets21CKK103211, Scer\GAL4Act.PU is a suppressor | partially | somatic clone of abnormal developmental rate | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, ftz-f1JF02738, scrib1

      (Külshammer et al., 2015)

      Ets21CKK103211, Scer\GAL4Act.PU is a suppressor | somatic clone of majority die during third instar larval stage | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, kay3, scrib1

      (Külshammer et al., 2015)
      NOT Suppressor of
      Statement
      Reference

      Ets21CKK103211, Scer\GAL4NP0001 is a non-suppressor of abnormal cell number | adult stage phenotype of Ras85DV12.UAS, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4NP0001 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Ras85DV12.UAS, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4NP0001 is a non-suppressor of abnormal endomitotic cell cycle | adult stage phenotype of Ras85DV12.UAS, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4esg.PU is a non-suppressor of increased cell number | adult stage phenotype of Ras85DV12.UAS, Scer\GAL4esg.PU

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4esg.PU is a non-suppressor of increased cell number | adult stage phenotype of Scer\GAL4esg.PU, btl::Egfrλ.UAS

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4NP0001 is a non-suppressor of abnormal cell number | adult stage phenotype of Scer\GAL4NP0001, btl::Egfrλ.UAS

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4NP0001 is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4NP0001, btl::Egfrλ.UAS

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4NP0001 is a non-suppressor of abnormal endomitotic cell cycle | adult stage phenotype of Scer\GAL4NP0001, btl::Egfrλ.UAS

      (Mundorf et al., 2019)

      Ets21CKK103211, Scer\GAL4Act.PU is a non-suppressor | somatic clone of neoplasia | somatic clone phenotype of Ras85DV12.UAS, Scer\GAL4Act.PU, scrib1

      (Külshammer et al., 2015)
      Other
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Third instar larval eye-antennal imaginal disc clones homozygous for scrib1 and expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU do not induce significant autophagosomes (assessed by a Atg8a fluorescence reporter) in neighboring disc cells if the clones also co-express both Ets21CKK103211 and kaydsRNA.Scer\UAS.cUa under the control of Scer\GAL4Act.PU.

      (Katheder et al., 2017)

      Larvae with eye-antennal disc clones co-expressing Ets21CKK103211 and Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU exhibit developmental delay, a noticeable enlargement of clonal tissue that eventually outcompetes the non-clonal tissue, defective photoreceptor differentiation, and clonal tissue exhibits invasive behavior and infiltrates the brain lobes and the ventral nerve cord, as compared to controls.

      Clonal co-expression of bskDN.Scer\UAS.cUa suppresses the invasiveness of clonal cells, but does not suppress tumor formation or developmental delay seen with eye-antennal disc clones co-expressing Ets21CKK103211 and Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU.

      Clonal co-expression of Ets21CKK103211 partially suppresses the lethality and developmental delay seen in larvae with scrib1 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU, but fails to suppress the invasive infiltration of the ventral nerve cord exhibited by cells of these clones.

      Larvae with scrib1, kay3 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS and Ets21CKK103211 under the control of Scer\GAL4Act.PU exhibit suppression of larval lethality as compared to either larvae with scrib1, kay3 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS under the control of Scer\GAL4Act.PU, or those with scrib1 mutant eye-antennal disc clones expressing Ras85DV12.Scer\UAS and Ets21CKK103211 under the control of Scer\GAL4Act.PU; but these larvae still exhibit pupal lethality.

      (Külshammer et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ets21CKK103211
      ets21c<up>LONG RNAi</up>
      (Külshammer et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)