FlyBase Allele Report: Dmel\ftz-f1[JF02738]

General Information

Symbol

Dmel\ftz-f1^JF02738

Species

D. melanogaster

Name

FlyBase ID

FBal0242320

Feature type

allele

Associated gene

Dmel\ftz-f1

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02738}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02738}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02738

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS, scrib¹

(Külshammer et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4²²¹

(Iyer et al., 2013)

abnormal neuroanatomy, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

increased mortality during development | parental effect, with Scer\GAL4^NP0001

(Parasram et al., 2024)

Phenotype Manifest In

abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.1.9

(Iyer et al., 2013)

larval dorsal multidendritic neuron ddaD, with Scer\GAL4²²¹

(Iyer et al., 2013)

Detailed Description

Statement

Reference

Expression of ftz-f1^JF02738 under the control of Scer\GAL4^Act.PU in clones in the eye-antennal disc does not result in any significant defect in eye-antennal disc morphology, photoreceptor differentiation, or adult eye development, as compared to controls.

(Külshammer et al., 2015)

Expression of ftz-f1^JF02738 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

(Ugrankar et al., 2015)

Expression of ftz-f1^JF02738 in C-I neurons under the control of Scer\GAL4²²¹ results in ddaD neurons that have an increased number of dendritic branches compared to controls.

Expression of ftz-f1^JF02738 in C-IV neurons under the control of Scer\GAL4^ppk.1.9 results in a reduction in total dendritic length in ddaC and v'ada neurons. The total number of dendritic branches is also reduced in ddaC neurons.

(Iyer et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has abnormal developmental rate | somatic clone phenotype, suppressible | partially | somatic clone by Ets21C^KK103211, Scer\GAL4^Act.PU

(Külshammer et al., 2015)

Suppressor of

Statement

Reference

ftz-f1^JF02738, Scer\GAL4^Act.PU is a suppressor | partially | somatic clone of majority die during third instar larval stage | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Külshammer et al., 2015)

ftz-f1^JF02738, Scer\GAL4^Act.PU is a suppressor | partially | somatic clone of abnormal developmental rate | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Külshammer et al., 2015)

ftz-f1^JF02738, Scer\GAL4^Act.PU is a suppressor | partially | somatic clone of abnormal developmental rate | somatic clone phenotype of Ets21C^KK103211, Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Külshammer et al., 2015)

ftz-f1^JF02738, Scer\GAL4^Act.PU is a suppressor | partially | somatic clone of neoplasia | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Külshammer et al., 2015)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has visible | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has abnormal size | somatic clone phenotype

(Külshammer et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

ftz-f1^JF02738, Scer\GAL4^Act.PU is a suppressor | partially | somatic clone of eye-antennal disc | somatic clone phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, scrib¹

(Külshammer et al., 2015)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has ommatidium | somatic clone phenotype

(Külshammer et al., 2015)

Ras85D^V12.UAS, Scer\GAL4^Act.PU, ftz-f1^JF02738, scrib¹ has eye | somatic clone phenotype

(Külshammer et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Clonal co-expression of ftz-f1^JF02738 partially suppresses the lethality and developmental delay seen in larvae with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, and suppresses the invasive infiltration of the ventral nerve cord exhibited by cells of these clones, although the tumor mass is not significantly decreased.

Larvae with scrib¹ mutant eye-antennal disc clones expressing ftz-f1^JF02738, Ets21C^KK103211, and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU reach pupation faster than larvae with scrib¹ mutant eye-antennal disc clones expressing ftz-f1^JF02738 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU, or those with scrib¹ mutant eye-antennal disc clones expressing Ets21C^KK103211 and Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Clonal co-expression of ftz-f1^JF02738 fails to suppress the defective photoreceptor differentiation seen in scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU.

Adults with scrib¹ mutant eye-antennal disc clones expressing Ras85D^V12.Scer\UAS and ftz-f1^JF02738 under the control of Scer\GAL4^Act.PU exhibit a rough eye that is increased in size, and contains fewer clonally-derived ommatidia, as compared to controls.

(Külshammer et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27659

y¹ v¹; P{TRiP.JF02738}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ftz-f1^JF02738

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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