FlyBase Allele Report: Dmel\Pvf1[KK112211]

General Information

Symbol

Dmel\Pvf1^KK112211

Species

D. melanogaster

Name

FlyBase ID

FBal0237969

Feature type

allele

Associated gene

Dmel\Pvf1

Associated Insertion(s)

Carried in Construct

P{KK112211}

Also Known As

UAS-Pvf1-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK112211}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK112211

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates intestinal cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Xu et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Pvf1^KK112211 under the control of Scer\GAL4^esg.PU or Scer\GAL4^NP0001, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, does not cause any obvious midgut phenotypes, compared to controls.

(Mundorf et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Pvf1^KK112211, Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Ets21C^{UAS.LONG.Tag:MYC}, Scer\GAL4^esg.PU

(Mundorf et al., 2019)

Pvf1^KK112211, Scer\GAL4^NP0001 is a suppressor of increased occurrence of cell division | adult stage phenotype of Ets21C^{UAS.LONG.Tag:MYC}, Scer\GAL4^NP0001

(Mundorf et al., 2019)

NOT Suppressor of

Statement

Reference

Pvf1^KK112211, Scer\GAL4^NP0001 is a non-suppressor of abnormal cell death | adult stage phenotype of Ets21C^{UAS.LONG.Tag:MYC}, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Pvf1^KK112211, Scer\GAL4^esg.PU is a suppressor of intestinal stem cell phenotype of Ets21C^{UAS.LONG.Tag:MYC}, Scer\GAL4^esg.PU

(Mundorf et al., 2019)

Pvf1^KK112211, Scer\GAL4^esg.PU is a suppressor | partially of adult midgut epithelium phenotype of Ets21C^{UAS.LONG.Tag:MYC}, Scer\GAL4^esg.PU

(Mundorf et al., 2019)

Pvf1^KK112211, Scer\GAL4^NP0001 is a suppressor of intestinal stem cell phenotype of Ets21C^{UAS.LONG.Tag:MYC}, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Pvf1^KK112211, Scer\GAL4^NP0001 is a suppressor | partially of adult midgut epithelium phenotype of Ets21C^{UAS.LONG.Tag:MYC}, Scer\GAL4^NP0001

(Mundorf et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102699

P{KK112211}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Pvf1^KK112211

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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