FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ets21CUAS.LONG.Tag:MYC
Open Close
General Information
Symbol
Dmel\Ets21CUAS.LONG.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0323833
Feature type
allele
Associated gene
Dmel\Ets21C
Associated Insertion(s)
Carried in Construct
P{UAS-Myc-Ets21C.LONG}
Key Links
Transgenic product class
wild_type
(Külshammer et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Külshammer et al., 2015)
Mutagen
in vitro construct
(Külshammer et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Myc-Ets21C.LONG}
Cytology
Description

UAS regulatory sequences drive expression of the coding sequence of the Ets21C-RA isoform. The protein is tagged at the N-terminal end with Tag:MYC.

(Külshammer et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Ets21C
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ets21CUAS.LONG.Tag:MYC under the control of Scer\GAL4esg.PU, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, significantly increases intestinal stem cell division, compared to controls, resulting in gut remodelling and increased epithelial turnover; adult females, but not males, also have significantly reduced survival when exposed to oxidative stress (paraquat), compared to controls.

      Expression of Ets21CUAS.LONG.Tag:MYC under the control of Scer\GAL4NP0001, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, increases apoptosis and results in loss of differentiated enterocytes; there is an increase in intestinal stem cell proliferation and numbers of immature pre-enterocytes; the posterior midgut is significantly increased in diameter and the epithelium undergoes luminal extrusion; these adults also have significantly reduced survival when exposed to oxidative stress (paraquat), compared to controls.

      (Mundorf et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4esg.PU has intestinal stem cell phenotype, suppressible by ImpGD9232, Scer\GAL4esg.PU

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4esg.PU has adult midgut epithelium phenotype, suppressible | partially by ImpGD9232, Scer\GAL4esg.PU

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has adult midgut enterocyte phenotype, suppressible | partially by Eip93FHMC04773, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has intestinal stem cell phenotype, suppressible by Eip93FHMC04773, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has adult midgut epithelium phenotype, suppressible | partially by Eip93FHMC04773, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has adult midgut enterocyte phenotype, suppressible | partially by BacA\p35UAS.cHa, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has intestinal stem cell phenotype, suppressible by BacA\p35UAS.cHa, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has adult midgut epithelium phenotype, suppressible | partially by BacA\p35UAS.cHa, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4esg.PU has intestinal stem cell phenotype, suppressible by Pvf1KK112211, Scer\GAL4esg.PU

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4esg.PU has adult midgut epithelium phenotype, suppressible | partially by Pvf1KK112211, Scer\GAL4esg.PU

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has intestinal stem cell phenotype, suppressible by Pvf1KK112211, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has adult midgut epithelium phenotype, suppressible | partially by Pvf1KK112211, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has intestinal stem cell phenotype, suppressible by upd3GD6811, Scer\GAL4NP0001

      (Mundorf et al., 2019)

      Ets21CUAS.LONG.Tag:MYC, Scer\GAL4NP0001 has adult midgut epithelium phenotype, suppressible | partially by upd3GD6811, Scer\GAL4NP0001

      (Mundorf et al., 2019)
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ets21CScer\UAS.LONG.T:Hsap\MYC
      Ets21CUAS.LONG.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (3)