FB2022_02, released March 29, 2022

Gene: Dmel\Pvf2

Open Close
General Information
Symbol
Dmel\Pvf2
Species
D. melanogaster
Name
PDGF- and VEGF-related factor 2
Annotation Symbol
CG13780
Feature Type
protein_coding_gene
FlyBase ID
FBgn0031888
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
PDGF- and VEGF-related factor 2 (Pvf2) encodes a ligand for the receptor tyrosine kinase enocded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DmVEGF-2, Pvf, Vegf27Cb, VEGF

Key Links
Genomic Location
Cytogenetic map
27E1-27E1
Sequence location
Recombination map
2-25
RefSeq locus
NT_033779 REGION:7069536..7084635
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables chemoattractant activity
inferred from mutant phenotype
(Wood et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables growth factor activity
inferred from electronic annotation with InterPro:IPR000072
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables vascular endothelial growth factor receptor binding
inferred from sequence or structural similarity with HGNC:12680
(Cho et al., 2002)
Biological Process (10 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in glial cell migration
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Learte et al., 2008)
involved_in hemocyte migration
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Parsons and Foley, 2013, Wood et al., 2006)
inferred from expression pattern
(Cho et al., 2002)
inferred from genetic interaction with FLYBASE:Pvf1; FB:FBgn0030964, FLYBASE:Pvf3; FB:FBgn0085407
(Cho et al., 2002)
involved_in hemocyte proliferation
inferred from mutant phenotype
(Munier et al., 2002)
involved_in lymph gland development
inferred from mutant phenotype
(Ferguson and Martinez-Agosto, 2017)
involved_in negative regulation of humoral immune response
inferred from mutant phenotype
(Tsuzuki et al., 2014)
involved_in positive regulation of cell migration
inferred from mutant phenotype
(Harris et al., 2007)
involved_in positive regulation of cell size
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Sims et al., 2009)
involved_in positive regulation of innate immune response
inferred from mutant phenotype
(Tsuzuki et al., 2014)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Harris et al., 2007)
involved_in vascular endothelial growth factor receptor signaling pathway
inferred from mutant phenotype
(Ragab et al., 2011, Sims et al., 2009)
(Read, 2018)
inferred from direct assay
(Tsuzuki et al., 2014)
inferred from genetic interaction with FLYBASE:Pvf3; FB:FBgn0085407
(Cho et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in hemocyte migration
inferred from biological aspect of ancestor with PANTHER:PTN001094163
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
is_active_in extracellular space
inferred from direct assay
(Tsuzuki et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR000072
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
PDGF- and VEGF-related factor 2 (Pvf2) encodes a ligand for the receptor tyrosine kinase enocded by Pvr. It has roles in embryonic plasmatocyte survival and migration, and in the proliferation of adult midgut intestinal stem cells. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Gene Group (FlyBase)
PDGF- AND VEGF-RELATED FACTORS -
PDGF- and VEGF-related factors bind and activate the PDGF/VEGF-receptor related receptor tyrosine kinase, Pvr. (Adapted from FBrf0221727.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pvf2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VM43)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pvf2-RA
FBtr0079423
NM_078775
2102
405
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pvf2-PA
FBpp0079051
46.9
405
8.62
NP_523499
AAF52484
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pvf2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
ventral midline of embryo
(Wheeler et al., 2009)
embryonic stage 9 -- 11
posterior ectoderm | restricted
(Cho et al., 2002)
embryonic hindgut
(Cho et al., 2002)
embryonic stage 9 -- 15
embryonic foregut
(Cho et al., 2002)
embryonic stage 11 -- 12
cardiogenic mesoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
Malpighian tubule primordium
(Fisher et al., 2012)
midline primordium
(Fisher et al., 2012)
embryonic stage 11 -- 13
larval ventral nerve cord
(Cho et al., 2002)
Malpighian tubule
(Cho et al., 2002)
embryonic stage 12 -- 15
ventral midline of embryo
(Wood et al., 2006)
embryonic stage 13 -- 14
ventral midline of embryo | dorsal
(Evans et al., 2010)
embryonic stage 13 -- 16
embryonic foregut
(Fisher et al., 2012)
embryonic leading edge cell
(Fisher et al., 2012)
embryonic Malpighian tubule
(Fisher et al., 2012)
embryonic salivary gland duct
(Fisher et al., 2012)
embryonic stomatogastric nervous system
(Fisher et al., 2012)
embryonic/larval circulatory system
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
embryonic stage 14
embryonic/larval dorsal vessel
(Wood et al., 2006)
Additional Descriptive Data

Pvf2 expression is restricted to the dorsal side of the midline in stage 13,14 embryos.

(Evans et al., 2010)

Pvf2 is expressed in the ventral midline starting at embryonic stage 12. Levels are strongest at stage 14. Over the next two hours of development, RNA levels decrease in a wave from anterior to posterior such that by stage 15 it is expressed in small, segmentally repeated points along the posterior region of the ventral nerve cord. These points of expression correspond to locations at which hemocytes cluster at the midline at this stage.

(Wood et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in extracellular space
inferred from direct assay
(Tsuzuki et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pvf2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pvf2
Transgenic constructs containing regulatory region of Pvf2
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(2L)Exel7030
(Ryder, 2004.4.26)
Df(2L)Mnn1Δ65
(Cerrato et al., 2006)
Gene partially disrupted in
Df(2L)Pvf2-3
(Parsons and Foley, 2013)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of P-stage, with Scer\GAL4Hml.Δ
lethal - all die before end of pupal stage, with Scer\GAL4da.G32
lethal - all die before end of pupal stage, with Scer\GAL4e33C
lethal - all die before end of second instar larval stage
partially lethal, with Scer\GAL4NP5130
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
decreased occurrence of cell division | adult stage
increased cell number | larval stage, with Scer\GAL4Hml.Δ
increased occurrence of cell division | adult stage, with Scer\GAL4NP5130
majority die during larval stage, with Scer\GAL4Hml.Δ
some die during pupal stage, with Scer\GAL4da.G32
some die during pupal stage, with Scer\GAL4e33C
Phenotype manifest in
Allele
adult midgut
adult midgut, with Scer\GAL4NP5130
embryonic/larval crystal cell, with Scer\GAL4e33C
embryonic/larval hemocyte
embryonic/larval hemocyte, with Scer\GAL4en-e16E
embryonic/larval hemocyte, with Scer\GAL4sim.PS
embryonic/larval hemocyte | increased number, with Scer\GAL4da.G32
embryonic/larval hemocyte | increased number, with Scer\GAL4e33C
embryonic/larval hemocyte | increased number | third instar larval stage, with Scer\GAL4Hml.Δ
embryonic/larval plasmatocyte, with Scer\GAL4e33C
enterocyte, with Scer\GAL4NP5130
enteroendocrine cell | increased number, with Scer\GAL4NP5130
hemocyte, with Scer\GAL4btl.PS
intestinal stem cell, with Scer\GAL4NP5130
lamellocyte | increased number | larval stage, with Scer\GAL4Hml.Δ
larval ventral nerve cord | embryonic stage, with Scer\GAL4en-e16E
lipid droplet | larval stage, with Scer\GAL4Hml.Δ
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\VEGFC
2 of 15
Yes
No
Hsap\PGF
1 of 15
No
No
Hsap\VEGFA
1 of 15
No
No
Hsap\VEGFB
1 of 15
No
No
Hsap\VEGFD
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Pgf
1 of 15
Yes
No
Mmus\Vegfa
1 of 15
Yes
No
Mmus\Vegfb
1 of 15
Yes
No
Mmus\Vegfc
1 of 15
Yes
No
Mmus\Vegfd
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (5)
Rnor\Vegfc
2 of 13
Yes
No
Rnor\Pgf
1 of 13
No
No
Rnor\Vegfa
1 of 13
No
No
Rnor\Vegfb
1 of 13
No
No
Rnor\Vegfd
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\pdgfb
1 of 12
Yes
No
Xtro\vegfa
1 of 12
Yes
No
Xtro\vegfb
1 of 12
Yes
No
Xtro\vegfc
1 of 12
Yes
No
Xtro\vegfd
1 of 12
Yes
No
Danio rerio (Zebrafish) (10)
Drer\pdgfbb
1 of 15
Yes
No
Drer\pgfa
1 of 15
Yes
Yes
Drer\pgfb
1 of 15
Yes
Yes
Drer\si:ch211-79m20.1
1 of 15
Yes
No
Drer\vegfaa
1 of 15
Yes
No
Drer\vegfab
1 of 15
Yes
No
Drer\vegfba
1 of 15
Yes
No
Drer\vegfbb
1 of 15
Yes
Yes
Drer\vegfc
1 of 15
Yes
No
Drer\vegfd
1 of 15
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\pvf-1
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Pvf3
3 of 10
Pvf1
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Pvf2 - P58IPK
    experimental knowledge based
    (Guruharsha et al., 2011)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Pvr Signaling Pathway Core Components -
    PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-25
    Cytogenetic map
    27E1-27E1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    27E1-27E1
    Limits computationally determined from genome sequence between P{PZ}snRNP70K02107 and P{PZ}wg02657
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    27C-27C
    (Larsen, 2002.2.19)
    27D6-27D6
    (Roos, 2001.6.13)
    Experimentally Determined Recombination Data
    Location

    2-25

    (FlyBase, 2016)

    2-23.2

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (12)
    Genomic Clones (23)
    cDNA Clones (20)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Tsuzuki et al., 2014)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Pvf2 CG13780

      (Rorth and Roos, 2001.8.16)
      Source for database merge of
      Additional comments

      "smi27E" may correspond to "Pvf2"; the P{lArB}smi27E1 insertion is 41bp downstream of "Pvf2".

      (Anholt et al., 2003)
      Other Comments

      Pvf2 has a role in controlling the embryonic migration of blood cells.

      (Cho et al., 2002)
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 37 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (16)
      Reported As
      Symbol Synonym
      CG13780
      (Mosallanejad et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Cho et al., 2002, Munier et al., 2002, Heino et al., 2001, Roos, 2001.6.14)
      DmVEGF-2
      (Heino et al., 2001)
      PV2
      (Bunt et al., 2007)
      PVF
      (Starz-Gaiano and Montell, 2004, Reif and Cyster, 2002)
      PVF2
      (Sopko and Perrimon, 2013, Hidalgo et al., 2011, McDonald et al., 2006, Montell, 2006, McDonald et al., 2004)
      PVFs
      (Ribeiro et al., 2003)
      Pvf
      (Zhang et al., 2013, Sims et al., 2009)
      Pvf2
      (DeAngelis et al., 2021, Millet-Boureima et al., 2021, Pan and O'Connor, 2021, Bakshi and Joshi, 2020, Cho et al., 2020, Nakajima et al., 2020, Pan et al., 2020, Ramond et al., 2020, Ramond et al., 2020, Zhou et al., 2020, Araki et al., 2019, Banerjee et al., 2019, Hall et al., 2019, Mele and Johnson, 2019, Douglas, 2018, Doupé et al., 2018, Jia et al., 2018, Read, 2018, Swevers et al., 2018, Ferguson and Martinez-Agosto, 2017, Liu and Jin, 2017, Transgenic RNAi Project members, 2017-, Ou et al., 2016, Parsons and Foley, 2016, Vanha-Aho et al., 2016, Doggett et al., 2015, Morán et al., 2015, Pasco et al., 2015, Ratheesh et al., 2015, Sansone et al., 2015, Bilak et al., 2014, Shlyueva et al., 2014, Tsuzuki et al., 2014, Wang et al., 2014, Mbodj et al., 2013, Parsons and Foley, 2013, Weavers and Skaer, 2013, Bond and Foley, 2012, Kelsey et al., 2012, Fauvarque and Williams, 2011, Marcu et al., 2011, Ragab et al., 2011, Razzell et al., 2011, Evans et al., 2010, Moreira et al., 2010, Siekhaus et al., 2010, Bond and Foley, 2009, Sims et al., 2009, Wheeler et al., 2009, Wu et al., 2009, Choi et al., 2008, Harris et al., 2007, Zeitlinger et al., 2007, Zeitouni et al., 2007, Cerrato et al., 2006, Wood et al., 2006, Johansson et al., 2005, Munier et al., 2002)
      VEGF
      (Dormann and Weijer, 2003, Traver and Zon, 2002)
      VEGF-2
      (Evans et al., 2003)
      VEGF27Cb
      (Larsen, 2002.2.19)
      Vegf27Cb
      (Cho et al., 2002, Cho et al., 2002)
      pvf2
      (Destalminil-Letourneau et al., 2021, Higareda Alvear et al., 2021, Ghosh et al., 2020, Liu et al., 2017, Ikmi et al., 2014, Zhang et al., 2013, Bunt et al., 2010, Learte et al., 2008, McDonald et al., 2003)
      Name Synonyms
      PDGF- and VEGF-receptor related factor 2
      (Zeitouni et al., 2007)
      PDGF- and VEGF-related factor 2
      (Marcu et al., 2011)
      VEGF-related factor 2
      (Boutros et al., 2002)
      Secondary FlyBase IDs
        Datasets (8)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (8)
        Result
        Result Type
        Title
        scRNAseq_2020_Cattenoz_NI_seq_clustering
        Clustering analysis of hemocytes from non-infested third instar larvae
        scRNAseq_2020_Cattenoz_WI_seq_clustering
        Clustering analysis of hemocytes from wasp-infested third instar larvae
        scRNAseq_2020_Cho_NI72LG_seq_clustering
        Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
        scRNAseq_2020_Cho_NI96LG_seq_clustering
        Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
        scRNAseq_2020_Cho_NI120LG_seq_clustering
        Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
        scRNAseq_2020_Cho_WI96LG_seq_clustering
        Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
        scRNAseq_2020_Cho_NI96HL_seq_clustering
        Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
        scRNAseq_2020_Cho_NI120HL_seq_clustering
        Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
        References (135)