FB2026_03 , released September 17, 2026
Pathway: PVR SIGNALING PATHWAY CORE COMPONENTS
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General Information
Name
PVR SIGNALING PATHWAY CORE COMPONENTS
Species
D. melanogaster
Symbol
PVR-C
FlyBase ID
FBgg0000973
Date last reviewed
2025-06-11
Number of members
33
Description
Description
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Notes and selected reviews
Biological Process Gene Ontology (GO) term(s)
vascular endothelial growth factor receptor signaling pathway
Related Gene Groups
Parent group(s)
PVR SIGNALING PATHWAY
Physical Interaction Network
Members (33)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
PVR-C
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components
PVR SIGNALING PATHWAY CORE COMPONENTS
Pvr Signaling Pathway Core Components
Secondary FlyBase ID(s)
References (17)