FB2026_03 , released September 17, 2026
Gene: Dmel\FASN3
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General Information
Symbol
Dmel\FASN3
Species
D. melanogaster
Name
Fatty acid synthase 3
Annotation Symbol
CG17374
Feature Type
protein_coding_gene
FlyBase ID
FBgn0287184
Gene Model Status
Current
Stock Availability
5 publicly available
Enzyme Name (EC)
[acyl-carrier-protein] S-acetyltransferase (2.3.1.38)
beta-ketoacyl-[acyl-carrier-protein] synthase I (2.3.1.41)
fatty-acid synthase system (2.3.1.85)
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

l4B, l(3)Lh4B, FASNCG17374, lethal 4B

Key Links
Genomic Location
Cytogenetic map
80F9-80F9
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:25752859..25762779
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity
inferred from electronic annotation with InterPro:IPR018201
(InterPro Project Members, 2004-)
enables [acyl-carrier-protein] S-acetyltransferase activity
inferred from sequence or structural similarity with UniProtKB:P49327
(Gene Ontology Curators, 2002-)
enables acyltransferase activity
inferred from electronic annotation with InterPro:IPR016039
(InterPro Project Members, 2004-)
enables fatty acid synthase activity
inferred from biological aspect of ancestor with PANTHER:PTN000196555
(GO Reference Genome Project, 2011-)
enables oxidoreductase activity
inferred from electronic annotation with InterPro:IPR020843
(InterPro Project Members, 2004-)
enables phosphopantetheine binding
inferred from electronic annotation with InterPro:IPR020806
(InterPro Project Members, 2004-)
enables transferase activity
inferred from electronic annotation with InterPro:IPR001227
(InterPro Project Members, 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in fatty acid biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN000196555
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR018201
(InterPro Project Members, 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group / Complex (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
[acyl-carrier-protein] S-acetyltransferase activity
holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA (2.3.1.38)
RHEA 41788: 3-oxoacyl-[acyl-carrier-protein] synthase activity
a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo- [ACP] + CO2 (2.3.1.41)
RHEA 22836: fatty acid synthase activity
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+) (2.3.1.85)
RHEA 14993:
Summaries
Gene Group / Complex (FlyBase)
FATTY ACID SYNTHASES -
Fatty acid elongation occurs in three cellular compartments: the cytosol, mitochondria, and endoplasmic reticulum (microsomes). In the cytosol, fatty acid elongation is part of de novo lipogenesis and involves acetyl-CoA carboxylase and fatty acid synthase. Fatty acid synthases utilize acetyl CoA and malonyl CoA to elongate fatty acids by two carbons. The primary end product of de novo lipogenesis is palmitate ( 16:0 ) and to a lesser extent myristate ( 14:0 ) and stearate ( 18:0 ). (Adapted from PMID:19763486.)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\FASN3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q7PLB8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FASN3-RC
FBtr0305959
NM_001015405
7395
2394
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FASN3 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.38

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult oenocyte
(Chung et al., 2014)
Additional Descriptive Data

FASN3 expression is detected at high levels in carcass but minimally in internal organs by RT-qPCR.

(Garrido et al., 2015)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\FASN3 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of FASN3
Transgenic constructs containing regulatory region of FASN3
Aberrations (Deficiencies and Duplications) ( 60 )
Inferred from experimentation ( 60 )
Gene disrupted in
Df(3L)1-16
(Schulze et al., 2001, Sinclair et al., 2000, Marchant and Holm, 1988)
Df(3L)1-17
(Marchant and Holm, 1988)
Df(3L)1-104
(Marchant and Holm, 1988)
Df(3L)1B-28
(Syrzycka et al., 2019)
Df(3L)2A-54
(Syrzycka et al., 2019)
Df(3L)2A-176
(Syrzycka et al., 2019)
Df(3L)3-10
(Marchant and Holm, 1988)
Df(3L)3-52
(Schulze et al., 2001)
Df(3L)3-135
(Marchant and Holm, 1988)
Df(3L)3A-243
(Syrzycka et al., 2019)
Df(3L)3B-296
(Syrzycka et al., 2019)
Df(3L)4-134
(Marchant and Holm, 1988)
Df(3L)4A-6
(Marchant and Holm, 1988)
Df(3L)4A-1677
(Syrzycka et al., 2019)
Df(3L)5-84
(Marchant and Holm, 1988)
Df(3L)5A-406
(Syrzycka et al., 2019)
Df(3L)6-21
(Marchant and Holm, 1988)
Df(3L)6B-29+Df(3R)6B-29
(Syrzycka et al., 2019, Schulze et al., 2001, Sinclair et al., 2000)
Df(3L)7B-75
(Syrzycka et al., 2019)
Df(3L)8-15
(Marchant and Holm, 1988)
Df(3L)8-68
(Marchant and Holm, 1988)
Df(3L)8A-80
(Marchant and Holm, 1988)
Df(3L)9-37
(Marchant and Holm, 1988)
Df(3L)9-52
(Marchant and Holm, 1988)
Df(3L)10-26+Df(3R)10-26
(Pauli et al., 1995)
Df(3L)10-39
(Marchant and Holm, 1988)
Df(3L)10-58
(Marchant and Holm, 1988)
Df(3L)10-109
(Marchant and Holm, 1988)
Df(3L)11B-1005
(Syrzycka et al., 2019)
Df(3L)13B-672
(Syrzycka et al., 2019)
Df(3L)14A-1343
(Syrzycka et al., 2019)
Df(3L)18A-1677
(Syrzycka et al., 2019)
Df(3L)99
(Schulze et al., 2001)
Df(3L)406
(Syrzycka et al., 2019)
Df(3L)C-2
(Syrzycka et al., 2019, Schulze et al., 2001, Sinclair et al., 2000)
Df(3L)DDD
(Syrzycka et al., 2019)
Df(3L)EEE
(Syrzycka et al., 2019)
Df(3L)FX53
(Syrzycka et al., 2019)
Df(3L)G-1
(Schulze et al., 2001, Sinclair et al., 2000)
Df(3L)γ-28
(Syrzycka et al., 2019, Schulze et al., 2001, Sinclair et al., 2000)
Df(3L)γ-29
(Schulze et al., 2001, Sinclair et al., 2000)
Df(3L)MX18
(Honda, 2019.5.6)
Df(3L)Snap253
(Syrzycka et al., 2019)
Df(3L)TTT
(Syrzycka et al., 2019)
Df(3L)vtd2
(Schulze et al., 2001)
Df(3L)vtd3
(Schulze et al., 2001)
Df(3L)vtd11
(Schulze et al., 2001)
Gene not disrupted in
Df(3L)1-166
(Schulze et al., 2001, Marchant and Holm, 1988)
Df(3L)2-66
(Schulze et al., 2001)
Df(3L)6-18
(Marchant and Holm, 1988)
Df(3L)9-56
(Schulze et al., 2001)
Df(3L)γ-26
(Schulze et al., 2001)
Df(3L)K-2
(Schulze et al., 2001)
Df(3L)O-1
(Schulze et al., 2001)
Df(3L)vtd6
(Schulze et al., 2001)
Df(3L)vtd7
(Schulze et al., 2001)
Df(3L)vtd8
(Schulze et al., 2001)
Df(3L)vtd10
(Schulze et al., 2001)
Df(3L)vtd12
(Schulze et al., 2001)
In(3L)vtd9
(Schulze et al., 2001)
Inferred from location ( 16 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Desat1.PB
lethal, with Scer\GAL4Tub.PU
lethal, with Scer\GAL4αTub84B.PL
lethal (with Df(3L)6B-29+Df(3R)6B-29)
lethal (with Df(3L)FX53)
lethal - all die during larval stage, with Scer\GAL4sal.BO
lethal - all die during second instar larval stage, with Scer\GAL4da.PU
viable, with Scer\GAL4Cg.PA
viable, with Scer\GAL4da.PU, Scer\GAL80svp.3kb
viable, with Scer\GAL4Mef2.PU
viable (with Df(3L)Δ1AK)
viable (with Df(3R)XM3)
Sterility
Allele
female fertile, with Scer\GAL4insc-Mz1407, Scer\GAL80svp.3kb
female fertile, with Scer\GAL4nanos.PU
female sterile, with Scer\GAL4Desat1.PB
female sterile, with Scer\GAL4insc-Mz1407
male fertile, with Scer\GAL4bam.PU
male fertile, with Scer\GAL4insc-Mz1407
Other Phenotypes
Allele
abnormal meiotic cell cycle | fertilized egg stage | maternal effect, with Scer\GAL4Desat1.PB
abnormal stress response | adult stage, with Scer\GAL4insc-Mz1407
decreased fecundity | progressive, with Scer\GAL4Desat1.PB
increased mortality during development | maternal effect, with Scer\GAL4Desat1.PB
Phenotype manifest in
Allele
embryonic/larval spiracle | larval stage, with Scer\GAL4sal.BO
fertilized egg | maternal effect, with Scer\GAL4Desat1.PB
nucleus | decreased number | fertilized egg stage | maternal effect, with Scer\GAL4Desat1.PB
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (17)
Hsap\FASN
9 of 14
Yes
No
Hsap\LINC00614
2 of 14
No
Yes
Hsap\ADH1A
1 of 14
No
No
1  
Hsap\ADH1B
1 of 14
No
No
Hsap\ADH1C
1 of 14
No
No
Hsap\ADH4
1 of 14
No
No
Hsap\ADH6
1 of 14
No
No
1  
Hsap\ADH7
1 of 14
No
No
1  
Hsap\CRYZ
1 of 14
No
No
Hsap\MCAT
1 of 14
No
No
Hsap\MECR
1 of 14
No
No
4  
Hsap\OXSM
1 of 14
No
No
Hsap\RTN4IP1
1 of 14
No
No
Hsap\TP53I3
1 of 14
No
No
Hsap\VAT1
1 of 14
No
No
1  
Hsap\VAT1L
1 of 14
No
No
Hsap\ZADH2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Fasn
9 of 14
Yes
No
Rnor\Cryz
1 of 14
No
No
Rnor\Mcat
1 of 14
No
No
Rnor\Oxsm
1 of 14
No
No
Rnor\Rtn4ip1
1 of 14
No
No
Rnor\Tp53i3
1 of 14
No
No
Rnor\Vat1l
1 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Fasn
8 of 14
Yes
No
Mmus\Cryzl2
1 of 14
No
No
Mmus\Cryz
1 of 14
No
No
Mmus\Mcat
1 of 14
No
No
Mmus\Oxsm
1 of 14
No
No
Mmus\Vat1l
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\fasn
4 of 13
Yes
No
Xtro\adh1c
1 of 13
No
No
Xtro\adh5
1 of 13
No
No
Xtro\alx1
1 of 13
No
No
Xtro\mcat
1 of 13
No
No
Xtro\mecr
1 of 13
No
No
Xtro\oxsm
1 of 13
No
No
Xtro\ptgr1.2
1 of 13
No
Yes
Xtro\ptgr1.3
1 of 13
No
Yes
Xtro\tp53i3
1 of 13
No
No
Xtro\vat1
1 of 13
No
Yes
Xtro\zadh2
1 of 13
No
No
Danio rerio (Zebrafish) (10)
Drer\fasn
9 of 14
Yes
No
Drer\ccdc57
7 of 14
No
No
Drer\fasn2
5 of 14
No
Yes
Drer\cryz
1 of 14
No
No
Drer\mcat
1 of 14
No
No
Drer\oxsm
1 of 14
No
No
Drer\pks1
1 of 14
No
Yes
Drer\rtn4ip1
1 of 14
No
No
Drer\vat1
1 of 14
No
No
Drer\vat1l
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\fasn-1
9 of 14
Yes
No
Cele\F32H2.6
4 of 14
No
Yes
Cele\pks-1
3 of 14
No
Yes
Cele\adh-5
1 of 14
No
No
Cele\C50D2.9
1 of 14
No
No
Cele\D2063.1
1 of 14
No
No
Cele\F10G8.9
1 of 14
No
No
Cele\F39B2.3
1 of 14
No
No
Cele\M106.3
1 of 14
No
No
Cele\mecr-1
1 of 14
No
No
Cele\rad-8
1 of 14
No
No
Cele\sodh-2
1 of 14
No
No
Cele\Y48A6B.9
1 of 14
No
No
Cele\ZK829.7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (13)
Agam\AgaP_AGAP001899
12 of 12
Yes
Yes
Agam\AgaP_AGAP008468
7 of 12
No
Yes
Agam\AgaP_AGAP009176
5 of 12
No
No
Agam\AgaP_AGAP000288
1 of 12
No
No
Agam\AgaP_AGAP000289
1 of 12
No
No
Agam\AgaP_AGAP002809
1 of 12
No
No
Agam\AgaP_AGAP005650
1 of 12
No
No
Agam\AgaP_AGAP006478
1 of 12
No
No
Agam\AgaP_AGAP009178
1 of 12
No
No
Agam\AgaP_AGAP009224
1 of 12
No
No
Agam\AgaP_AGAP011189
1 of 12
No
No
Agam\AgaP_AGAP011633
1 of 12
No
No
Agam\AgaP_AGAP011834
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (15)
Atha\AT4G21580
3 of 13
Yes
No
Atha\AOR
2 of 13
No
No
Atha\AT5G61510
2 of 13
No
No
Atha\AT5G63620
2 of 13
No
No
Atha\NQR
2 of 13
No
No
Atha\AT1G22440
1 of 13
No
No
Atha\AT2G04540
1 of 13
No
No
Atha\AT3G15090
1 of 13
No
No
Atha\AT3G45770
1 of 13
No
No
Atha\AT3G56460
1 of 13
No
No
Atha\AT4G13010
1 of 13
No
No
Atha\AT5G51970
1 of 13
No
No
Atha\EMB3147
1 of 13
No
No
Atha\FAB1
1 of 13
No
No
Atha\KASI
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (10)
Scer\ADH1
1 of 13
Yes
No
Scer\ADH2
1 of 13
Yes
No
Scer\ADH3
1 of 13
Yes
No
Scer\ADH5
1 of 13
Yes
No
Scer\AST1
1 of 13
Yes
No
Scer\AST2
1 of 13
Yes
No
Scer\CEM1
1 of 13
Yes
No
Scer\YCR102C
1 of 13
Yes
No
Scer\YIM1
1 of 13
Yes
No
Scer\ZTA1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\SPBC1773.06c
3 of 12
Yes
No
Spom\SPBC16A3.02c
2 of 12
No
No
Spom\SPAC11G7.05c
1 of 12
No
No
Spom\SPBC887.13c
1 of 12
No
No
Spom\zta1
1 of 12
No
No
Escherichia coli (enterobacterium) (3)
Ecol\fabB
1 of 11
Yes
No
Ecol\fabD
1 of 11
Yes
No
Ecol\fabF
1 of 11
Yes
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:FASN3. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (7)
FASN2
8 of 13
FASN1
7 of 13
Rtn4ip1
2 of 13
beg
1 of 13
CG12170
1 of 13
Drat
1 of 13
Mecr
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FASN; fatty acid synthase
    9 of 14
    600212
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        Summary of Genetic Interactions
        Interaction Browsers
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-47
        Cytogenetic map
        80F9-80F9
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        80F9-80F9
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        h48-h50
        (Drosophila Heterochromatin Genome Project, 2004)
        Experimentally Determined Recombination Data
        Location

        3-47

        (FlyBase, 2016)

        3-44.1

        (Comeron et al., 2012)

        3-[47]

        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (5)
        Genomic Clones (11)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (4)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Cell Line Information
              Publicly Available Cell Lines
               
                Other Stable Cell Lines
                 
                  Other Comments

                  Fatty acid synthase (FASN) is encoded by three distinct genes: CG3523, CG3524 and CG17374. Of these, CG3523 is the only FASN gene that is expressed in internal organs, has an essential function (outside of oenocytes), and whose expression affects total triacylglycerol levels in vivo.

                  (Garrido et al., 2015)

                  One of a series of EMS-induced lethals detected by failure to complement proximal heterochromatic deficiencies in 3L or 3R, which resulted from detachments, i.e., reconstitutions of normal third chromosomes, from irradiated C(3L)RM/C(3R)RM-bearing females; a large set of such proximal heterochromatic deficiencies was employed in deficiency mapping of these lethals (Marchant and Holm, 1988).

                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: FASN3 l(3)80Ff

                  (Syrzycka et al., 2019)
                  Additional comments
                  Nomenclature History
                  Source for database identify of

                  Source for identity of: FASN3 CG17374

                  (FlyBase, 2009-)
                  Nomenclature comments

                  There are 3 Fatty acid synthase genes in the Dmel genome (FBrf0219401, FBrf0224329): CG3523 (aka FAS), CG3524 (aka mFAS) and CG17374. The CG3523 gene product is the major, ubiquitously expressed Fatty acid synthase of the three (and the most studied), while CG3524 and CG17374 have lower and more restricted expression (FBrf0219401, FBrf0224329; also see modENCODE RNAseq). The following systematic and informative symbols have therefore been adopted: CG3523 = 'FASN1', CG3524 = 'FASN2' and CG17374 = 'FASN3'. ('FASN', rather than 'FAS', has been used as a shared prefix as this more clearly distinguishes these 'Fatty acid synthase' genes from the unrelated 'faint sausage' gene (symbol 'fas') and 'Fasciclin' genes (symbols 'Fas1', 'Fas2' and 'Fas3'). Furthermore 'FASN' is the HGNC symbol for the human ortholog.)

                  (FlyBase, 2009-)
                  Etymology
                  Synonyms and Secondary IDs (16)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
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                  Study result (0)
                  Result
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                  External Crossreferences and Linkouts ( 58 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  Linkouts
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  References (67)