FlyBase Allele Report: Scer\GAL4[Desat1.PB]

ScerGAL4^Desat1.PB drives expression in a pattern that largely recapitulates that of the Desat-RE transcript. It drives expression in larval oenocytes, adult female oenocytes, and in the male reproductive system.

(Billeter et al., 2009)

Marker for

adult oenocyte

(Wu et al., 2023)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | adult stage, with Dmoj\mElo^UAS.cWa

(Wang et al., 2023)

abnormal behavior | adult stage, with fru^KK112763

(Sun et al., 2023)

abnormal behavior | adult stage | female, with mElo^UAS.cWa

(Wang et al., 2023)

abnormal courtship behavior, with dsx^HMC03795

(Sun et al., 2023)

abnormal courtship behavior, with fru^JF01182

(Sun et al., 2023)

abnormal courtship behavior, with fru^KK112763

(Sun et al., 2023)

abnormal courtship behavior, with Hnf4^HMC05862

(Sun et al., 2023)

abnormal courtship behavior, with Hnf4^JF02539

(Sun et al., 2023)

abnormal courtship behavior, with Scer\GAL80^ts.αTub84B, hid^UAS.cZa

(Billeter et al., 2009)

abnormal developmental rate | male | heat sensitive, with Scer\GAL80^ts.αTub84B, spidey^GD3274

(Chiang et al., 2016)

abnormal endomitotic cell cycle | larval stage | nutrition conditional, with Pi3K92E^UAS.Tag:MYC

(Cinnamon et al., 2016)

abnormal endomitotic cell cycle | larval stage | nutrition conditional, with spidey^NIG.1444R

(Cinnamon et al., 2016)

abnormal mating rhythm | male, with cyc^{Δ.UAS.Tag:MYC}

(Krupp et al., 2013)

abnormal meiotic cell cycle | fertilized egg stage | maternal effect, with CG6432^GD11925

(Poidevin et al., 2024)

abnormal meiotic cell cycle | fertilized egg stage | maternal effect, with FASN3^RNAi.WIZ.UAS

(Poidevin et al., 2024)

abnormal starvation stress response | larval stage, with Acc^GD3482

(Cinnamon et al., 2016)

abnormal starvation stress response | larval stage, with Cpr^GD945

(Cinnamon et al., 2016)

abnormal starvation stress response | larval stage, with Cyp4g1^RNAi.UAS

(Cinnamon et al., 2016)

abnormal starvation stress response | larval stage, with FarO^GD3202

(Cinnamon et al., 2016)

abnormal starvation stress response | larval stage, with mdy^GD1749

(Cinnamon et al., 2016)

abnormal starvation stress response | larval stage, with spidey^NIG.1444R

(Cinnamon et al., 2016)

decreased cell size | larval stage, with Pi3K92E^A2860C.UAS

(Cinnamon et al., 2016)

decreased fecundity | progressive, with Acc^GD3482

(Poidevin et al., 2024)

decreased fecundity | progressive, with CG6432^GD11925

(Poidevin et al., 2024)

decreased fecundity | progressive, with CG6432^HMJ22106

(Poidevin et al., 2024)

decreased fecundity | progressive, with CG6660^HMJ23876

(Poidevin et al., 2024)

decreased fecundity | progressive, with CG6660^KK106710

(Poidevin et al., 2024)

decreased fecundity | progressive, with CG6660^NIG.6660R

(Poidevin et al., 2024)

decreased fecundity | progressive, with FASN3^HMS05300

(Poidevin et al., 2024)

decreased fecundity | progressive, with FASN3^RNAi.WIZ.UAS

(Poidevin et al., 2024)

decreased fecundity | progressive, with Fatp1^GD1069

(Poidevin et al., 2024)

decreased fecundity | progressive, with Fatp1^KK104809

(Poidevin et al., 2024)

decreased fecundity | progressive, with spidey^GD3274

(Poidevin et al., 2024)

decreased fecundity | progressive, with spidey^HMC05887

(Poidevin et al., 2024)

decreased rate of feeding behavior | adult stage, with fru^KK112763

(Sun et al., 2023)

female sterile, with Acc^GD3482

(Poidevin et al., 2024)

female sterile, with CG6432^GD11925

(Poidevin et al., 2024)

female sterile, with CG6432^HMJ22106

(Poidevin et al., 2024)

female sterile, with CG6660^HMJ23876

(Poidevin et al., 2024)

female sterile, with CG6660^KK106710

(Poidevin et al., 2024)

female sterile, with CG6660^NIG.6660R

(Poidevin et al., 2024)

female sterile, with FASN3^HMS05300

(Poidevin et al., 2024)

female sterile, with FASN3^RNAi.WIZ.UAS

(Poidevin et al., 2024)

female sterile, with Fatp1^GD1069

(Poidevin et al., 2024)

female sterile, with Fatp1^KK104809

(Poidevin et al., 2024)

female sterile, with spidey^GD3274

(Poidevin et al., 2024)

female sterile, with spidey^HMC05887

(Poidevin et al., 2024)

increased cell size | larval stage, with FarO^GD3202

(Cinnamon et al., 2016)

increased cell size | larval stage, with Pi3K92E^UAS.Tag:MYC

(Cinnamon et al., 2016)

increased cell size | larval stage, with spidey^NIG.1444R

(Cinnamon et al., 2016)

increased mortality during development | maternal effect, with CG6432^GD11925

(Poidevin et al., 2024)

increased mortality during development | maternal effect, with FASN3^RNAi.WIZ.UAS

(Poidevin et al., 2024)

increased rate of adult locomotory behavior | adult stage, with fru^KK112763

(Sun et al., 2023)

lethal, with FASN3^RNAi.UAS

(Chung et al., 2014)

lethal, with hid^UAS.cZa

(Billeter et al., 2009)

lethal - all die before end of P-stage, with Cyp18a1^UAS.cGa

(Scanlan and Robin, 2024)

lethal - all die before end of P-stage | heat sensitive, with Scer\GAL80^ts.αTub84B, spidey^GD3274

(Chiang et al., 2016)

lethal - all die before end of P-stage | heat sensitive, with Scer\GAL80^ts.αTub84B, spidey^{UAS.ORF.GW.Tag:HA}

(Chiang et al., 2016)

majority die during prepupal stage, with spidey^UAS.cCa

(Chiang et al., 2016)

partially lethal - majority die | female | heat sensitive, with Scer\GAL80^ts.αTub84B, spidey^GD3274

(Chiang et al., 2016)

partially lethal - majority live | male | heat sensitive, with Scer\GAL80^ts.αTub84B, spidey^GD3274

(Chiang et al., 2016)

some die during pharate adult stage, with spidey^UAS.cCa

(Chiang et al., 2016)

some die during pharate adult stage | heat sensitive, with Scer\GAL80^ts.αTub84B, spidey^{UAS.ORF.GW.Tag:HA}

(Chiang et al., 2016)

some die during prepupal stage | recessive | heat sensitive, with Scer\GAL80^ts.αTub84B, spidey^{UAS.ORF.GW.Tag:HA}

(Chiang et al., 2016)

viable, with FASN2^KK106426

(Chung et al., 2014)

viable, with Scer\GAL80^ts.αTub84B, hid^UAS.cZa

(Billeter et al., 2009)

viable, with wall^EY20330

(Scanlan and Robin, 2024)

viable, with wall^UAS.pU

(Scanlan and Robin, 2024)

Phenotype Manifest In

adult midgut region R3, with Hnf4^HMC05862

(Vonolfen et al., 2024)

adult midgut region R3, with Hnf4^NIG.9310R

(Vonolfen et al., 2024)

adult midgut region R3, with Nplp2^GD4710

(Vonolfen et al., 2024)

adult midgut region R5, with Hnf4^HMC05862

(Vonolfen et al., 2024)

adult midgut region R5, with Nplp2^GD4710

(Vonolfen et al., 2024)

adult oenocyte, with Scer\GAL80^ts.αTub84B, hid^UAS.cZa

(Billeter et al., 2009)

adult oenocyte, with spidey^GD3274

(Chiang et al., 2016)

embryonic/larval oenocyte | larval stage, with Acc^GD3482

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage, with Cyp4g1^RNAi.UAS

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage, with FarO^GD3202

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage, with Pi3K92E^A2860C.UAS

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage, with Pi3K92E^UAS.Tag:MYC

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage, with spidey^NIG.1444R

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage | nutrition conditional, with Acc^GD3482

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage | nutrition conditional, with Cpr^GD945

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage | nutrition conditional, with FarO^GD3202

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage | nutrition conditional, with Lsd-2^UAS.cGa

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage | nutrition conditional, with mdy^GD1749

(Cinnamon et al., 2016)

embryonic/larval oenocyte | larval stage | nutrition conditional, with spidey^GD3274

(Cinnamon et al., 2016)

embryonic/larval spiracle | larval stage, with Acc^GD3482

(Parvy et al., 2012)

embryonic/larval spiracle | larval stage, with grim^UAS.cNa

(Parvy et al., 2012)

embryonic/larval tracheal section | larval stage, with Acc^GD3482

(Cinnamon et al., 2016)

embryonic/larval tracheal section | larval stage, with rpr^UAS.C

(Cinnamon et al., 2016)

embryonic/larval tracheal section | larval stage, with spidey^NIG.1444R

(Cinnamon et al., 2016)

fertilized egg | maternal effect, with CG6432^GD11925

(Poidevin et al., 2024)

fertilized egg | maternal effect, with FASN3^RNAi.WIZ.UAS

(Poidevin et al., 2024)

leg | P-stage, with spidey^GD3274

(Chiang et al., 2016)

lipid droplet | adult stage, with Hnf4^HMC05862

(Vonolfen et al., 2024)

lipid droplet | adult stage, with Hnf4^NIG.9310R

(Vonolfen et al., 2024)

lipid droplet | adult stage, with Nplp2^GD4710

(Vonolfen et al., 2024)

lipid droplet | adult stage | increased number, with fru^KK112763

(Sun et al., 2023)

lipid droplet | adult stage | increased number, with Hnf4^JF02539

(Sun et al., 2023)

nucleus | decreased number | fertilized egg stage | maternal effect, with CG6432^GD11925

(Poidevin et al., 2024)

nucleus | decreased number | fertilized egg stage | maternal effect, with FASN3^RNAi.WIZ.UAS

(Poidevin et al., 2024)

nucleus | larval stage | nutrition conditional, with FarO^GD3202

(Cinnamon et al., 2016)

nucleus | larval stage | nutrition conditional, with spidey^GD3274

(Cinnamon et al., 2016)

nucleus | larval stage | nutrition conditional, with spidey^NIG.1444R

(Cinnamon et al., 2016)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Desat1.PB, spidey^NIG.1444R has abnormal starvation stress response | larval stage phenotype, non-enhanceable by Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

Suppressed by

Statement

Reference

Scer\GAL4^Desat1.PB, fru^KK112763 has abnormal courtship behavior phenotype, suppressible | partially by Hnf4^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^Desat1.PB

(Sun et al., 2023)

Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB has decreased cell size | larval stage phenotype, suppressible by FarO^GD3202, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

Scer\GAL4^Desat1.PB, spidey^NIG.1444R has increased cell size | larval stage phenotype, suppressible | partially by Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

NOT suppressed by

Statement

Reference

Scer\GAL4^Desat1.PB, spidey^NIG.1444R has abnormal starvation stress response | larval stage phenotype, non-suppressible by Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

NOT Enhancer of

Statement

Reference

Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB is a non-enhancer of abnormal starvation stress response | larval stage phenotype of Scer\GAL4^Desat1.PB, spidey^NIG.1444R

(Cinnamon et al., 2016)

Suppressor of

Statement

Reference

Hnf4^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^Desat1.PB is a suppressor | partially of abnormal courtship behavior phenotype of Scer\GAL4^Desat1.PB, fru^KK112763

(Sun et al., 2023)

FarO^GD3202, Scer\GAL4^Desat1.PB is a suppressor of decreased cell size | larval stage phenotype of Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB is a suppressor | partially of increased cell size | larval stage phenotype of Scer\GAL4^Desat1.PB, spidey^NIG.1444R

(Cinnamon et al., 2016)

NOT Suppressor of

Statement

Reference

InR^K1409A.UAS/Scer\GAL4^Desat1.PB is a non-suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB is a non-suppressor of abnormal starvation stress response | larval stage phenotype of Scer\GAL4^Desat1.PB, spidey^NIG.1444R

(Cinnamon et al., 2016)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Desat1.PB, spidey^NIG.1444R has embryonic/larval oenocyte | larval stage phenotype, non-enhanceable by Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

Suppressed by

Statement

Reference

Scer\GAL4^Desat1.PB, fru^KK112763 has lipid droplet | increased number | adult stage phenotype, suppressible | partially by Hnf4^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^Desat1.PB

(Sun et al., 2023)

Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB has embryonic/larval oenocyte | larval stage phenotype, suppressible by FarO^GD3202, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

Scer\GAL4^Desat1.PB, spidey^NIG.1444R has embryonic/larval oenocyte | larval stage phenotype, suppressible | partially by Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

NOT Enhancer of

Statement

Reference

Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB is a non-enhancer of embryonic/larval oenocyte | larval stage phenotype of Scer\GAL4^Desat1.PB, spidey^NIG.1444R

(Cinnamon et al., 2016)

Suppressor of

Statement

Reference

Hnf4^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^Desat1.PB is a suppressor | partially of lipid droplet | increased number | adult stage phenotype of Scer\GAL4^Desat1.PB, fru^KK112763

(Sun et al., 2023)

Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB is a suppressor | partially of embryonic/larval oenocyte | larval stage phenotype of Scer\GAL4^Desat1.PB, spidey^NIG.1444R

(Cinnamon et al., 2016)

FarO^GD3202, Scer\GAL4^Desat1.PB is a suppressor of embryonic/larval oenocyte | larval stage phenotype of Pi3K92E^A2860C.UAS, Scer\GAL4^Desat1.PB

(Cinnamon et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

PGRP-LB^UAS.PC.EGFP/Scer\GAL4^Desat1.PB rescues PGRP-LB^Δ

(Charroux et al., 2018)

Partially rescues

Scer\GAL4^Desat1.PB/fru^B.UAS.cSa partially rescues fru^KK112763

(Sun et al., 2023)

Fails to rescue

Pgr^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^Desat1.PB fails to rescue Pgr^A1/Pgr^B1

(Fujinaga et al., 2025)

cPges^{UAS.Tag:FLAG,Tag:HA}/Scer\GAL4^Desat1.PB fails to rescue cPges^KO

(Fujinaga et al., 2025)

Scer\GAL4^Desat1.PB/PGRP-LB^UAS.PA.EGFP fails to rescue PGRP-LB^Δ

(Charroux et al., 2018)

Scer\GAL4^Desat1.PB/PGRP-LB^{UAS.PC-C177S.EGFP} fails to rescue PGRP-LB^Δ

(Charroux et al., 2018)

Scer\GAL4^Desat1.PB/PGRP-LB^UAS.PD.EGFP fails to rescue PGRP-LB^Δ

(Charroux et al., 2018)

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

65405

w^*; P{Desat1-GAL4.E800}4M

65404

w^*; P{Desat1-GAL4.E800}2M/CyO

65407

P{Desat1-GAL4.E800}4M, P{tubP-GAL80^ts}2

65406

P{Desat1-GAL4.E800}2M, P{tubP-GAL80^ts}20

606649

w^*; P{Desat1-GAL4.E800}4M, P{UAS-sfGFP-TurboID-ER}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Scer\GAL4^Desat1.PB

Scer\GAL4^desat1.PB

oeno^Gal4

(Charroux et al., 2018)

Name Synonyms

desat1 promoter construct of Billeter

Secondary FlyBase IDs

References (49)

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