FlyBase Allele Report: Dmel\Ras85D[V12.GMR]

General Information

Symbol

Dmel\Ras85D^V12.GMR

Species

D. melanogaster

Name

FlyBase ID

FBal0122002

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

Carried in Construct

P{GMR-Ras85D.V12}

Also Known As

GMR-ras^v12

Key Links

Transgenic product class

missense_variant

(Tang et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Tang et al., 2001)

Mutagen

in vitro construct

(Tang et al., 2001)

Progenitor genotype

Carried in construct

P{GMR-Ras85D.V12}

Cytology

Description

GMR regulatory sequences drive expression of a constitutively active form of Ras85D.

(Tang et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Ras85D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Okada et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is ameliorated by InR^GL00139

(Okada et al., 2023)

is ameliorated by InR^JF01183

(Okada et al., 2023)

is ameliorated by InR^JF01482

(Okada et al., 2023)

is ameliorated by NetB^VSH330183

(Okada et al., 2023)

is ameliorated by InR^K1409A.UAS

(Okada et al., 2023)

is ameliorated by NetB^Δ

(Okada et al., 2023)

is ameliorated by NetB^KK103672

(Okada et al., 2023)

is ameliorated by unc-5^HMS01099

(Okada et al., 2023)

is ameliorated by unc-5^KK102074

(Okada et al., 2023)

is ameliorated by unc-5^MI04273

(Okada et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | adult stage

(Okada et al., 2023)

partially lethal - majority die

(Okada et al., 2023)

short lived

(Okada et al., 2023)

visible | adult stage

(Okada et al., 2023)

Phenotype Manifest In

eye

(Okada et al., 2023)

eye disc

(Okada et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ras85D^V12.GMR has increased mortality during development phenotype, enhanceable by Tmlh^GD11285/Scer\GAL4^Cg.PA

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, enhanceable by Scer\GAL4^fat/Tmlh^GD11285

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, enhanceable by Scer\GAL4^Cg.PA/Tmlh^HMC04962

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, enhanceable by Scer\GAL4^fat/CPT2^HMC03474

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, enhanceable by Scer\GAL4^fat/CPT2^HMJ23935

(Okada et al., 2023)

Suppressed by

Statement

Reference

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by NetB^KK103672/Scer\GAL4^GMR.PU

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by NetB^VSH330183/Scer\GAL4^GMR.PU

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by NetB^Δ

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Scer\GAL4^fat/unc-5^KK102074

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by unc-5^MI04273

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by InR^GL00139/Scer\GAL4^Cg.PA

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Scer\GAL4^Cg.PA/InR^JF01183

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by InR^K1409A.UAS/Scer\GAL4^Cg.PA

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Scer\GAL4^Cg.PA/InR^JF01482

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Ilp2¹

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Ilp3¹

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Ilp5¹

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Ilp3¹/Ilp5¹/Ilp2¹

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Scer\GAL4^fat/InR^K1409A.UAS

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, suppressible by Scer\GAL4^fat/unc-5^HMS01099

(Okada et al., 2023)

NOT suppressed by

Statement

Reference

Ras85D^V12.GMR has decreased size | adult stage phenotype, non-suppressible by NetB^KK103672/Scer\GAL4^GMR.PU

(Okada et al., 2023)

Ras85D^V12.GMR has visible | adult stage phenotype, non-suppressible by NetB^KK103672/Scer\GAL4^GMR.PU

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, non-suppressible by InR^K1409A.UAS/Scer\GAL4^Desat1.PB

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, non-suppressible by InR^K1409A.UAS/Scer\GAL4^esg.PU

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, non-suppressible by InR^K1409A.UAS/Scer\GAL4^GMR.PU

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, non-suppressible by InR^K1409A.UAS/Scer\GAL4^Mef2.PR

(Okada et al., 2023)

Ras85D^V12.GMR has increased mortality during development phenotype, non-suppressible by InR^K1409A.UAS/Scer\GAL4^nub.PU

(Okada et al., 2023)

Suppressor of

Statement

Reference

Ras85D^V12.GMR is a suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ras85D^V12.GMR has phenotype, suppressible by lilli^XS575

(Tang et al., 2001)

Ras85D^V12.GMR has phenotype, suppressible by lilli^XS407

(Tang et al., 2001)

Ras85D^V12.GMR has phenotype, suppressible by lilli^s35

(Tang et al., 2001)

NOT suppressed by

Statement

Reference

Ras85D^V12.GMR has eye phenotype, non-suppressible by NetB^KK103672/Scer\GAL4^GMR.PU

(Okada et al., 2023)

Suppressor of

Statement

Reference

Ras85D^V12.GMR is a suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ras85D^V12.GMR

[Ras^v12]^gl

(Sullivan and Rubin, 2002)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections