FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ilp21
Open Close
General Information
Symbol
Dmel\Ilp21
Species
D. melanogaster
Name
FlyBase ID
FBal0243891
Feature type
allele
Associated gene
Dmel\Ilp2
Associated Insertion(s)
TI{TI}Ilp21
Carried in Construct
Also Known As
dilp21, dilp2 KO
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
I-SceI
(Grönke et al., 2010)
FLPase
(Grönke et al., 2010)
ends-out gene targeting
(Grönke et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}Ilp21
Cytology
Description

The entire Ilp2 coding sequence has been replaced by a w+mW.hs marker.

(Grönke et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  fragile X syndrome
      modeled by Fmr13
      (Weisz et al., 2024, Monyak et al., 2017)
      ameliorates  cancer
      modeled by scrib1
      (Sanaki et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ilp21 homozygous mutant third instar larvae present similar numbers of abdominal adult muscle precursor cells, as compared to controls.

      (Aradhya et al., 2015)

      Female Ilp21 flies show a significantly reduced re-mating rate 24 hours after mating to wild-type flies, compared to control flies.

      (Wigby et al., 2011)

      Ilp21 mutants are 100% viable; show a delay in egg-to-adult development time; show a slight reduction in adult body weight; have an increased median lifespan (at all food concentrations, excepting starvation conditions); have significantly reduced lifetime fecundity; show normal paraquat resistance, starvation resistance, and lipid and glycogen storage; and increased whole body trehalose levels.

      (Grönke et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Other
      Statement
      Reference

      Ilp21, Ilp31, Ilp51, foxoΔ94 has lethal phenotype

      (Slack et al., 2011)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Ilp21/Ilp21 is a suppressor of ommatidium | cell non-autonomous phenotype of TBC1d7KO

      (Ren et al., 2018)

      Ilp21/Ilp21 is a suppressor of wing phenotype of TBC1d7KO

      (Ren et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Female Ilp21 flies show a significantly reduced re-mating rate 5 hours after mating to Acp70A0 flies.

      (Wigby et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ilp21 is rescued by Ilp2gd2.Tag:HA,Tag:FLAG

      (Park et al., 2014)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (9)
      References (30)