Glucose levels are significantly elevated in Df(3L)Ilp2-3, Ilp53 mutant larvae.
Df(3L)Ilp2-3 mutant flies live for approximately 30% longer than controls on both sugar-yeast and holidic (containing 50mM sucrose and 200mM biologically available nitrogen) media.
Central nervous system neuroblasts of fed Df(3L)Ilp2-3 second instar larvae show a moderate reduction in EdU incorporation compared to controls.
Female Df(3L)Ilp2-3 flies show a significantly reduced re-mating rate 24 hours after mating to wild-type flies, compared to control flies. The fecundity of females is reduced in these flies.
Df(3L)Ilp2-3 mutants are 100% viable; show a slight reduction in adult body weight; have increased median lifespan (females); show reduced lifetime fecundity; and show normal paraquat resistance and starvation resistance.