FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ilp53
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General Information
Symbol
Dmel\Ilp53
Species
D. melanogaster
Name
FlyBase ID
FBal0243969
Feature type
allele
Associated gene
Dmel\Ilp5
Associated Insertion(s)
TI{TI}Ilp53
Carried in Construct
Also Known As
dilp53
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
I-SceI
(Gronke, 2010.5.12)
FLPase
(Gronke, 2010.5.12)
ends-out gene targeting
(Gronke, 2010.5.12)
Progenitor genotype
Associated Insertion(s)
TI{TI}Ilp53
Cytology
Description

The entire Ilp5 coding sequence has been replaced by a w+mW.hs marker.

(Gronke, 2010.5.12)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by scrib1
      (Sanaki et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Glucose levels are significantly elevated in Df(3L)Ilp2-3, Ilp53 mutant larvae.

      (Ugrankar et al., 2015)

      Development from egg to adult of Df(3L)Ilp2-3, Ilp53 animals takes ~6 days longer than controls. Adults show reduced wing length and elevated levels of trehalose.

      (Park et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Df(3L)Ilp2-3, Ilp53 has wing phenotype, suppressible | partially by Ilp2+tgd2

      (Park et al., 2014)

      Df(3L)Ilp2-3, Ilp53 has wing phenotype, suppressible | partially by Ilp2gd2.Tag:HA,Tag:FLAG

      (Park et al., 2014)
      NOT suppressed by
      Statement
      Reference

      Df(3L)Ilp2-3, Ilp53 has wing phenotype, non-suppressible by Ilp2C119Y.gd2.Tag:HA,Tag:FLAG

      (Park et al., 2014)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Central nervous system neuroblasts of fed Df(3L)Ilp2-3 Ilp53 second instar larvae show a strong reduction in EdU incorporation compared to controls.

      (Sousa-Nunes et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (16)