FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TBC1d7KO
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General Information
Symbol
Dmel\TBC1d7KO
Species
D. melanogaster
Name
FlyBase ID
FBal0343481
Feature type
allele
Associated gene
Dmel\TBC1d7
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Ren et al., 2018)
Mutagen
CRISPR/Cas9
(Ren et al., 2018)
Progenitor genotype
Cytology
Description

Deletion of an 800bp fragment, including the first exon and part of the second exon of TBC1d7.

(Ren et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TBC1d7KO homozygotes exhibit a significant decrease in adult climbing ability and increased body size both at pupal and adult stages; TBC1d7KO homozygotes also show a significant increase in adult body weight, small but significant increases in ommatidia area and wing area.

      TBC1d7KO homozygotes show vacuolated mitochondria with disrupted cristae in the indirect flight muscles, as compared to controls.

      (Ren et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      TBC1d7KO has ommatidium | cell non-autonomous phenotype, suppressible by Ilp21/Ilp21

      (Ren et al., 2018)

      TBC1d7KO has wing phenotype, suppressible by Ilp21/Ilp21

      (Ren et al., 2018)

      TBC1d7KO has ommatidium | cell non-autonomous phenotype, suppressible by Scer\GAL4Ilp2.PR/Hsap\TBC1D7UAS.cRa

      (Ren et al., 2018)

      TBC1d7KO has wing phenotype, suppressible | partially by Scer\GAL4Ilp2.PR/Hsap\TBC1D7UAS.cRa

      (Ren et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      TBC1d7KO is partially rescued by TBC1d7UAS.cRa/Scer\GAL4da.G32

      (Ren et al., 2018)

      TBC1d7KO is partially rescued by TBC1d7UAS.cRa/Scer\GAL4elav-C155

      (Ren et al., 2018)

      TBC1d7KO is partially rescued by TBC1d7UAS.cRa/Scer\GAL4Ilp2.PR

      (Ren et al., 2018)

      TBC1d7KO is partially rescued by TBC1d7125Q.UAS/Scer\GAL4Ilp2.PR

      (Ren et al., 2018)
      Not rescued by

      TBC1d7KO is not rescued by TBC1d7UAS.cRa/Scer\GAL4Mhc.PK

      (Ren et al., 2018)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TBC1d7KO
      dTBC1D7KO
      (Ren et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)