FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NetBΔ
Open Close
General Information
Symbol
Dmel\NetBΔ
Species
D. melanogaster
Name
FlyBase ID
FBal0260874
Feature type
allele
Associated gene
Dmel\NetB
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Brankatschk and Dickson, 2006)
Progenitor genotype
P{GawB}NP6098
(Brankatschk and Dickson, 2006)
Cytology
Description

A 4184 bp deletion resulting from the imprecise excision of P{GawB}NP6098 removing promoter sequences and the first 370 codons of NetB.

(Brankatschk and Dickson, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:14,746,952..14,751,135 [-]
Comment:

Approximate boundaries of 4184 bp deletion resulting from the imprecise excision of P{GawB}NP6098. The deletion removes the first 370 codons of NetB and part of the 5' UTR.

(Brankatschk and Dickson, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by Ras85DV12.GMR
      (Okada et al., 2023)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rh6-positive R8 axons target correctly to the M3 layer in the optic lobe in NetAΔ mutants.

      (Timofeev et al., 2012)

      The number of embryonic peripheral glia (ePG) present on the intersegmental nerve distal to the SNc nerve branch is reduced compared to wild type.

      (von Hilchen et al., 2010)

      The commissural axons appear to form normally in homozygous NetBΔ mutants. Both the anterior and posterior commissures are intact and of normal size in every segment in the NetBΔ mutants.

      (Brankatschk and Dickson, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      NetBΔ is an enhancer of visible | adult stage phenotype of hidGMR.PG

      (Newquist et al., 2013)
      Suppressor of
      Statement
      Reference

      NetBΔ is a suppressor of increased mortality during development phenotype of Ras85DV12.GMR

      (Okada et al., 2023)
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      NetBΔ is a suppressor of eye phenotype of hidGMR.PG

      (Newquist et al., 2013)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      NetBΔ enhances the cell death seen in flies expressing WGMR.PG, resulting in a further reduced eye size.

      (Newquist et al., 2013)

      Both ventral nerve cord commissures are absent in every segment of embryos expressing unc-5Scer\UAS.cKa under the control of Scer\GAL41407 in a homozygous NetBΔ mutant genetic background.

      Homozygous NetBΔ has little effect on long-range repulsion of axons expressing unc-5Scer\UAS.cKa under the control of Scer\GAL4ato-NP6558.

      (Brankatschk and Dickson, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (9)