FlyBase Allele Report: Scer\GAL4[fat]

General Information

Symbol

Scer\GAL4^fat

Species

S. cerevisiae

Name

FlyBase ID

FBal0098822

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GAL4}fat

Carried in Construct

Also Known As

FB-GAL4, fatbody-GAL4, P{w^+mW.hs=GawB}FB+SNS, FBGal4, Fat body Gal4

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Maxton-Kuchenmeister et al., 1999)

Progenitor genotype

Associated Insertion(s)

P{GAL4}fat

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GAL4}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval fat body

(Rynes et al., 2012, Zhao et al., 2012, Ballard et al., 2010, Grönke et al., 2007, Lind et al., 2006)

embryonic/larval midgut

(Rynes et al., 2012)

third instar larval stage

embryonic/larval fat body

(Gronke et al., 2003, Maxton-Kuchenmeister et al., 1999)

adult stage

adult fat body

(Missirlis et al., 2003)

Additional Information

Statement

Reference

Drives expression in fat bodies.

(FlyBase Curators, 2017)

Marker for

embryonic/larval fat body

(Thiel et al., 2013, Gronke et al., 2003)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | pupal stage, with ohgt^GD11111

(Wakabayashi et al., 2016)

abnormal cell size | larval stage, with Axn¹²⁷, Axn^HMJ23888

(Zhang et al., 2017)

abnormal cell size | larval stage, with Xlae\gsk3b.L^DN.UAS

(Zhang et al., 2017)

abnormal developmental rate, with Lsd-1^GD6641

(Men et al., 2016)

abnormal developmental rate, with Noc1^RNAi.UAS.cUa

(Destefanis et al., 2022)

abnormal developmental rate, with Noc2^HMJ03129

(Destefanis et al., 2022)

abnormal developmental rate, with Noc3^HMJ23361

(Destefanis et al., 2022)

abnormal feeding behavior | adult stage, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

abnormal immune response | adult stage, with Hmgcl^HMC03435

(Krejčová et al., 2025)

abnormal immune response | adult stage, with Hmgs^HMC04928

(Krejčová et al., 2025)

abnormal locomotor behavior | adult stage, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

abnormal size | adult stage | progressive, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

abnormal size | larval stage, with Lime^UAS.GFP

(Mihajlovic et al., 2019)

abnormal starvation stress response, with bez^GD2224, bez^NIG.3829R

(Carrera et al., 2024)

abnormal starvation stress response | adult stage, with HDAC1^GL01005

(Nakajima et al., 2016)

abnormal starvation stress response | adult stage, with HDAC1^JF01401

(Nakajima et al., 2016)

abnormal starvation stress response | adult stage, with HDAC1^UAS.Tag:V5

(Nakajima et al., 2016)

abnormal starvation stress response | adult stage, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

abnormal stress response, with Lsd-1^RNAi.UAS.cBa

(Beller et al., 2010)

decreased body size | P-stage, with Noc1^RNAi.UAS.cUa

(Destefanis et al., 2022)

decreased body size | P-stage, with Noc2^HMJ03129

(Destefanis et al., 2022)

decreased body size | P-stage, with Noc3^HMJ23361

(Destefanis et al., 2022)

decreased cell number | larval stage, with Lime^UAS.GFP

(Mihajlovic et al., 2019)

decreased rate of adult locomotory behavior | conditional, with Hmgcl^HMC03435

(Krejčová et al., 2025)

female sterile, with bez^GD2224, bez^NIG.3829R

(Carrera et al., 2024)

increased cell death | oogenesis, with bez^GD2224, bez^NIG.3829R

(Carrera et al., 2024)

increased cell size | adult stage | progressive, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

increased mortality, with bez^GD2224, bez^NIG.3829R

(Carrera et al., 2024)

increased mortality | conditional, with Hmgcl^HMC03435

(Krejčová et al., 2025)

increased mortality | conditional, with Hmgs^HMC04928

(Krejčová et al., 2025)

lethal, with Atg1^UAS.cSa

(Bjedov et al., 2020)

lethal, with Noc1^RNAi.UAS.cUa

(Destefanis et al., 2022)

lethal, with Noc2^HMJ03129

(Destefanis et al., 2022)

lethal, with Noc3^HMJ23361

(Destefanis et al., 2022)

lethal | heat sensitive, with Lsd-1^GD6641

(Men et al., 2016)

lethal - all die before end of pupal stage, with adp^UAS.cHa

(Hader et al., 2003)

lethal - all die before end of pupal stage | heat sensitive, with Aven^GD9098

(Zou et al., 2011)

long lived, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

long lived | calorie restriction conditional, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

short lived, with Sams^KK107709

(Obata and Miura, 2015)

some die during larval stage, with Noc1^RNAi.UAS.cUa

(Destefanis et al., 2022)

some die during larval stage, with Noc2^HMJ03129

(Destefanis et al., 2022)

some die during larval stage, with Noc3^HMJ23361

(Destefanis et al., 2022)

some die during P-stage, with Noc1^RNAi.UAS.cUa

(Destefanis et al., 2022)

some die during P-stage, with Noc2^HMJ03129

(Destefanis et al., 2022)

some die during P-stage, with Noc3^HMJ23361

(Destefanis et al., 2022)

some die during pupal stage, with adp^UAS.cHa

(Hader et al., 2003)

some die during pupal stage | heat sensitive, with Aven^GD9098

(Zou et al., 2011)

viable, with Irp-1A^UAS.cLa

(Lind et al., 2006)

viable, with Irp-1B^UAS.cLa

(Lind et al., 2006)

viable, with Noc1^{UAS.ORF.GW.Tag:HA}

(Destefanis et al., 2022)

visible | larval stage, with Axn¹²⁷, Axn^HMJ23888

(Zhang et al., 2017)

visible | larval stage, with Xlae\gsk3b.L^DN.UAS

(Zhang et al., 2017)

Phenotype Manifest In

adult abdomen | progressive, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

adult abdominal fat mass | progressive, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

adult fat body, with bmm^UAS.cGa

(Gronke et al., 2005)

adult fat body, with bmm^UAS.EGFP

(Gronke et al., 2005)

egg chamber, with bez^GD2224, bez^NIG.3829R

(Carrera et al., 2024)

embryonic/larval fat body, with adp^UAS.cHa

(Hader et al., 2003)

embryonic/larval fat body | third instar larval stage, with FIG4^KK102943

(Kyotani et al., 2016)

embryonic/larval hemocyte | larval stage, with Lime^UAS.GFP

(Mihajlovic et al., 2019)

embryonic/larval lymph gland | larval stage, with Lime^UAS.GFP

(Mihajlovic et al., 2019)

embryonic/larval oenocyte, with InR^K1409A.UAS

(Kohyama-Koganeya et al., 2008)

embryonic/larval salivary gland | third instar larval stage, with sturkopf^KK108771

(Thiel et al., 2013)

fat body, with Atg5^RNAi.UAS

(Scott et al., 2004)

fat body, with gbb^RNAi.UAS.cBa

(Ballard et al., 2010)

fat body, with Lsd-2^UAS.cGa

(Gronke et al., 2003)

fat cell | adult stage | progressive, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

larval abdomen, with Axn¹²⁷, Axn^HMJ23888

(Zhang et al., 2017)

larval abdomen, with Xlae\gsk3b.L^DN.UAS

(Zhang et al., 2017)

larval fat cell, with Axn¹²⁷, Axn^HMJ23888

(Zhang et al., 2017)

larval fat cell, with Xlae\gsk3b.L^DN.UAS

(Zhang et al., 2017)

lipid droplet, with Akh^UAS.cLa

(Grönke et al., 2007)

lipid droplet, with Lsd-1^RNAi.UAS.cBa

(Beller et al., 2010)

lipid droplet, with sturkopf^KK108771

(Thiel et al., 2013)

lipid droplet | adult stage | progressive, with Stim^RNAi.cEa.UAS

(Xu et al., 2019)

lysosome | third instar larval stage, with FIG4^KK102943

(Kyotani et al., 2016)

oocyte, with bez^GD2224, bez^NIG.3829R

(Carrera et al., 2024)

ovary, with bez^GD2224, bez^NIG.3829R

(Carrera et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^fat/Tmlh^GD11285 is an enhancer of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Scer\GAL4^fat/CPT2^HMC03474 is an enhancer of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Scer\GAL4^fat/CPT2^HMJ23935 is an enhancer of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Scer\GAL4^fat/α-Cat^HMS00317 is an enhancer of visible | larval stage phenotype of Axn¹²⁷

(Zhang et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^fat/unc-5^KK102074 is a suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Scer\GAL4^fat/InR^K1409A.UAS is a suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Scer\GAL4^fat/unc-5^HMS01099 is a suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Scer\GAL4^fat/Hsap\ATF3^UAS.Tag:FLAG is a suppressor | partially of lethal phenotype of Atf3⁷⁶

(Rynes et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\GAL4^fat/Hsap\PLIN1^UAS.cBa is a non-suppressor of increased body size phenotype of Lsd-1¹

(Beller et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^fat, bmm^UAS.cGa has phenotype, suppressible | partially by Lsd-2^UAS.cGa, Scer\GAL4^fat

(Gronke et al., 2005)

Enhancer of

Statement

Reference

Scer\GAL4^fat/α-Cat^HMS00317 is an enhancer of larval abdomen phenotype of Axn¹²⁷

(Zhang et al., 2017)

Suppressor of

Statement

Reference

Scer\GAL4^fat/Hsap\ATF3^UAS.Tag:FLAG is a suppressor | partially of lipid droplet phenotype of Atf3⁷⁶

(Rynes et al., 2012)

Lsd-2^UAS.cGa, Scer\GAL4^fat is a suppressor | partially of phenotype of Scer\GAL4^fat, bmm^UAS.cGa

(Gronke et al., 2005)

NOT Suppressor of

Statement

Reference

Scer\GAL4^fat/Hsap\PLIN1^UAS.cBa is a non-suppressor of lipid droplet phenotype of Lsd-1¹

(Beller et al., 2010)

Scer\GAL4^fat/Akh^UAS.cLa is a non-suppressor of lipid droplet phenotype of AkhR¹

(Grönke et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^fat, Scer\GAL4^c601, Scer\GAL4^byn-Gal4, Axn^EY10228 rescues Axn^EY10228/Axn¹²⁷

(Zhang et al., 2017)

Sik3^UAS.Tag:HA/Scer\GAL4^fat rescues Sik3⁴⁸

(Wang et al., 2011)

Scer\GAL4^fat/gbb^UAS.cKa rescues gbb¹

(Ballard et al., 2010)

Scer\GAL4^fat/Lsd-1^UAS.cBa rescues Lsd-1¹

(Beller et al., 2010)

Scer\GAL4^fat/cu^RC.UAS.EGFP rescues cu³

(Grönke et al., 2009)

Scer\GAL4^fat/Hnf4^UAS.cPa rescues Hnf4^Δ17/Hnf4^Δ33

(Palanker et al., 2009)

Scer\GAL4^fat/Lsd-2^UAS.cGa rescues Lsd-2^KG00149

(Gronke et al., 2003)

Partially rescues

Scer\GAL4^fat/Hsl^UAS.cHa partially rescues Hsl¹

(Heier et al., 2021)

puml^UAS.PA/Scer\GAL4^fat partially rescues puml¹

(Hehlert et al., 2019)

Scer\GAL4^fat/Axn^EY10228 partially rescues Axn^EY10228/Axn¹²⁷

(Zhang et al., 2017)

Fails to rescue

Scer\GAL4^fat/Sik3^{K70M.UAS.Tag:HA} fails to rescue Sik3⁴⁸

(Wang et al., 2011)

Scer\GAL4^fat/Sik3^{T196A.UAS.Tag:HA} fails to rescue Sik3⁴⁸

(Wang et al., 2011)

Scer\GAL4^fat/Sik3^{4A.UAS.Tag:HA} fails to rescue Sik3⁴⁸

(Wang et al., 2011)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scer\GAL4^fat

fat body specific Gal4 driver

(Gronke et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (77)

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