FlyBase Allele Report: Dmel\adp[UAS.cHa]

General Information

Symbol

Dmel\adp^UAS.cHa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Hader

FlyBase ID

FBal0240641

Feature type

allele

Associated gene

Dmel\adp

Associated Insertion(s)

Carried in Construct

P{UAS-adp.H}

Key Links

Transgenic product class

cDNA

(Hader et al., 2003)

wild_type

(Hader et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Hader et al., 2003)

wild_type

(Hader et al., 2003)

Mutagen

in vitro construct

(Hader et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-adp.H}

Cytology

Description

UAS regulatory sequences drive expression of a wild-type adp cDNA.

(Hader et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

adp

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile, with Scer\GAL4^elav-C155

(Hader et al., 2003)

lethal - all die before end of pupal stage, with Scer\GAL4^fat

(Hader et al., 2003)

some die during pupal stage, with Scer\GAL4^fat

(Hader et al., 2003)

viable, with Scer\GAL4^elav-C155

(Hader et al., 2003)

Phenotype Manifest In

embryonic/larval fat body, with Scer\GAL4^fat

(Hader et al., 2003)

fat body, with Scer\GAL4^DcG

(Suh et al., 2007)

fat body, with Scer\GAL4^FBI-19

(Suh et al., 2007)

Detailed Description

Statement

Reference

Expression of adp^Scer\UAS.cHa in a fat restricted manner under the control of Scer\GAL4^DcG inhibits fat formation and the size of the fat body.

Upon RU486 treatment, expression of adp⁶⁰ under the control of Scer\GAL4^FBI-19 results in reduced fat accumulation as compared with those treated with vehicle.

(Suh et al., 2007)

Larvae expressing adp^Scer\UAS.cHa under the control of Scer\GAL4^fat have reduced triglyceride levels compared to control larvae. The amount of fat body tissue is significantly reduced compared to controls in third instar larvae expressing adp^Scer\UAS.cHa under the control of Scer\GAL4^fat. These animals continue to develop until pupation, but die in the pupal case.

Third instar larvae expressing adp^Scer\UAS.cHa under the control of Scer\GAL4^elav-C155 have a normal triglyceride content and develop into normal-looking, healthy, fertile adults.

Larvae expressing adp^Scer\UAS.cHa under the control of Scer\GAL4^how-24B have normal triglyceride levels.

Expression of adp^Scer\UAS.cHa under the control of Scer\GAL4^F4 does not result in any visible defects in the salivary glands.

(Hader et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

adp^Scer\UAS.cHa

adp^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Hader

Secondary FlyBase IDs

References (2)

Report Sections

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