FlyBase Allele Report: Dmel\Axn[127]

General Information

Symbol

Dmel\Axn¹²⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0302752

Feature type

allele

Associated gene

Dmel\Axn

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Zhang et al., 2014)

Progenitor genotype

Cytology

Description

Exon 10 of Axn is linked to a repetitive heterochromatin sequence instead of exon 11.

(Zhang et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell size | larval stage

(Zhang et al., 2017)

abnormal cell size | larval stage, with Axn^HMJ23888, Scer\GAL4^fat

(Zhang et al., 2017)

abnormal cell size | larval stage, with Axn^HMJ23888, SREBP^GAL4::VP16

(Zhang et al., 2017)

abnormal cell size | larval stage (with Axn^EY10228)

(Zhang et al., 2017)

abnormal starvation stress response

(Zhang et al., 2014)

abnormal starvation stress response | somatic clone

(Zhang et al., 2014)

increased cell death | somatic clone | nutrition conditional

(Zhang et al., 2014)

lethal - all die before end of pupal stage

(Zhang et al., 2014)

visible | larval stage

(Zhang et al., 2017)

visible | larval stage, with Axn^HMJ23888, Scer\GAL4^fat

(Zhang et al., 2017)

visible | larval stage, with Axn^HMJ23888, SREBP^GAL4::VP16

(Zhang et al., 2017)

visible | larval stage (with Axn^EY10228)

(Zhang et al., 2017)

Phenotype Manifest In

eye disc | somatic clone | nutrition conditional

(Zhang et al., 2014)

larval abdomen

(Zhang et al., 2017)

larval abdomen, with Axn^HMJ23888, Scer\GAL4^fat

(Zhang et al., 2017)

larval abdomen, with Axn^HMJ23888, SREBP^GAL4::VP16

(Zhang et al., 2017)

larval abdomen (with Axn^EY10228)

(Zhang et al., 2017)

larval fat cell

(Zhang et al., 2017)

larval fat cell, with Axn^HMJ23888, Scer\GAL4^fat

(Zhang et al., 2017)

larval fat cell, with Axn^HMJ23888, SREBP^GAL4::VP16

(Zhang et al., 2017)

larval fat cell (with Axn^EY10228)

(Zhang et al., 2017)

Detailed Description

Statement

Reference

Axn¹²⁷ mutant larvae are more sensitive to fasting than controls, and this sensitivity can be largely suppressed by the addition of glutamine to food. Fasting also results in increased levels of apoptosis in Axn¹²⁷ mutant eye disc clones compared to controls. Very little apoptosis is seen in non-fasted Axn¹²⁷ mutant eye discs.

(Zhang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Axn¹²⁷ has visible | larval stage phenotype, enhanceable by Scer\GAL4^fat/α-Cat^HMS00317

(Zhang et al., 2017)

Axn¹²⁷ has abnormal starvation stress response phenotype, enhanceable by Rbf^120a

(Zhang et al., 2014)

Axn¹²⁷ has abnormal starvation stress response | somatic clone phenotype, enhanceable by Lkb1^X5

(Zhang et al., 2014)

Axn¹²⁷ has increased cell death | somatic clone | nutrition conditional phenotype, enhanceable by Lkb1^X5

(Zhang et al., 2014)

Suppressed by

Statement

Reference

Axn¹²⁷ has visible | larval stage phenotype, suppressible by pan^JF02306/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Axn¹²⁷ has visible | larval stage phenotype, suppressible by lgs^GL00619/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Axn¹²⁷ has visible | larval stage phenotype, suppressible by pygo^GL00647/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Axn¹²⁷ has visible | larval stage phenotype, suppressible by SREBP^GAL4::VP16/pan^JF02306

(Zhang et al., 2017)

Axn¹²⁷ has visible | larval stage phenotype, suppressible by SREBP^GAL4::VP16/lgs^GL00619

(Zhang et al., 2017)

Axn¹²⁷ has visible | larval stage phenotype, suppressible by SREBP^GAL4::VP16/α-Cat^UAS.sgGFP

(Zhang et al., 2017)

Axn¹²⁷ has abnormal cell size | larval stage phenotype, suppressible | partially by SREBP^GAL4::VP16/α-Cat^UAS.sgGFP

(Zhang et al., 2017)

Axn¹²⁷ has visible | larval stage phenotype, suppressible by arm^HMS01414/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Enhancer of

Statement

Reference

Axn¹²⁷ is an enhancer of increased cell death | somatic clone phenotype of Rbf^15aΔ

(Zhang et al., 2014)

Axn¹²⁷ is an enhancer of abnormal starvation stress response phenotype of Rbf^120a

(Zhang et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Axn¹²⁷ has larval abdomen phenotype, enhanceable by Scer\GAL4^fat/α-Cat^HMS00317

(Zhang et al., 2017)

Axn¹²⁷ has eye disc | somatic clone | nutrition conditional phenotype, enhanceable by Lkb1^X5

(Zhang et al., 2014)

Suppressed by

Statement

Reference

Axn¹²⁷ has larval abdomen phenotype, suppressible by arm^HMS01414/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Axn¹²⁷ has larval abdomen phenotype, suppressible by pan^JF02306/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Axn¹²⁷ has larval abdomen phenotype, suppressible by lgs^GL00619/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Axn¹²⁷ has larval abdomen phenotype, suppressible by pygo^GL00647/Scer\GAL4^arm.PS

(Zhang et al., 2017)

Axn¹²⁷ has larval abdomen phenotype, suppressible by SREBP^GAL4::VP16/pan^JF02306

(Zhang et al., 2017)

Axn¹²⁷ has larval abdomen phenotype, suppressible by SREBP^GAL4::VP16/lgs^GL00619

(Zhang et al., 2017)

Axn¹²⁷ has larval abdomen phenotype, suppressible by SREBP^GAL4::VP16/α-Cat^UAS.sgGFP

(Zhang et al., 2017)

Axn¹²⁷ has larval fat cell phenotype, suppressible | partially by SREBP^GAL4::VP16/α-Cat^UAS.sgGFP

(Zhang et al., 2017)

Enhancer of

Statement

Reference

Axn¹²⁷ is an enhancer of eye | somatic clone phenotype of Rbf^15aΔ

(Zhang et al., 2014)

Axn¹²⁷ is an enhancer of eye disc | somatic clone phenotype of Rbf^15aΔ

(Zhang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Axn¹²⁷ enhances the decrease in clone size seen in Rbf^15aΔ mutant adult eyes.

lkb1^X5 enhances the increase in apoptosis seen in Axn¹²⁷ mutant eye disc clones following fasting for three hours

Axn¹²⁷ Rbf^120a double mutant larvae show enhanced sensitivity to fasting than either mutant alone.

(Zhang et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Axn^EY10228/Axn¹²⁷ is rescued by Scer\GAL4^arm.PS/Axn^EY10228

(Zhang et al., 2017)

Axn^EY10228/Axn¹²⁷ is rescued by Scer\GAL4^fat/Scer\GAL4^c601/Scer\GAL4^byn-Gal4/Axn^EY10228

(Zhang et al., 2017)

Axn^EY10228/Axn¹²⁷ is rescued by SREBP^GAL4::VP16/Axn^EY10228

(Zhang et al., 2017)

Partially rescued by

Axn^EY10228/Axn¹²⁷ is partially rescued by Scer\GAL4^fat/Axn^EY10228

(Zhang et al., 2017)

Axn^EY10228/Axn¹²⁷ is partially rescued by Scer\GAL4^c601/Scer\GAL4^byn-Gal4/Axn^EY10228

(Zhang et al., 2017)

Axn¹²⁷ is partially rescued by Axn^UAS.GFP/Scer\GAL4^hs.PU

(Zhang et al., 2014)

Comments

Expression of Axn^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^hs.PU partially rescues the pupal lethality seen in Axn¹²⁷ mutants, resulting in the development of adult flies without obvious defects.

(Zhang et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

606863

w^*; Axn¹²⁷/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Axn¹²⁷

(Liu et al., 2024, Zhang et al., 2017)

axn¹²⁷

(Zhang et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close