FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sik348
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General Information
Symbol
Dmel\Sik348
Species
D. melanogaster
Name
FlyBase ID
FBal0265610
Feature type
allele
Associated gene
Dmel\Sik3
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Wang et al., 2011)
Progenitor genotype
P{EPgy2}Sik3EY06260
(Wang et al., 2011)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes the first exon of Sik3.

(Wang et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sik348 mutants exhibit reduced sleep time in both a 12/12 light/dark cycle and in constant darkness, as compared to controls.

      (Funato et al., 2016)

      Homozygous adults have markedly reduced lipid stores and are more sensitive to starvation than controls.

      (Wang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Sik2Scer\UAS.cWa under the control of Scer\GAL4fat rescues lipid levels in Sik348 flies.

      Expression of either Akt1Scer\UAS.Exel or SNF1ATD.Scer\UAS under the control of Scer\GAL4fat does not rescue lipid levels in Sik348 flies.

      Lipid levels are partially restored in GRHR1 Sik348 double mutant flies.

      Lipid levels are completely restored in bmm1 Sik348, Sik348 ; foxo21/foxo25 and HDAC4KG09091/HDAC4e04575 ; Sik348double mutant flies.

      (Wang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Sik348 is rescued by Sik3UAS.Tag:HA/Scer\GAL4fat

      (Wang et al., 2011)
      Not rescued by

      Sik348 is not rescued by Scer\GAL4fat/Sik3K70M.UAS.Tag:HA

      (Wang et al., 2011)

      Sik348 is not rescued by Scer\GAL4fat/Sik3T196A.UAS.Tag:HA

      (Wang et al., 2011)

      Sik348 is not rescued by Scer\GAL4fat/Sik34A.UAS.Tag:HA

      (Wang et al., 2011)
      Comments

      Expression of Sik3Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4fat rescues lipid levels and starvation resistance in Sik348 flies.

      Expression of Sik34A.Scer\UAS.T:Ivir\HA1, Sik3K70M.Scer\UAS.T:Ivir\HA1 or Sik3T196A.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4fat fails to rescue lipid levels in Sik348 flies.

      (Wang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SIK348
      (Wang et al., 2011)
      Sik3(hypo)
      (Funato et al., 2016)
      Sik348
      Name Synonyms
      Secondary FlyBase IDs
        References (2)