FlyBase Allele Report: Dmel\HDAC1[GL01005]

General Information

Symbol

Dmel\HDAC1^GL01005

Species

D. melanogaster

Name

FlyBase ID

FBal0266332

Feature type

allele

Associated gene

Dmel\HDAC1

Associated Insertion(s)

Carried in Construct

P{TRiP.GL01005}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL01005}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL01005

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates acute myeloid leukemia

modeled by Hsap\HOXA9::Hsap\NUP98^WT.UAS

(Gavory et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage, with Scer\GAL4^fat

(Nakajima et al., 2016)

Phenotype Manifest In

adult fat body | nutrition conditional, with Scer\GAL4^Cg.PA

(Molaei et al., 2019)

Detailed Description

Statement

Reference

Expressing HDAC1^GL01005 under the control of Scer\GAL4^Cg.PA results in a significantly decreased lipid storage in the fat body of starved adult flies.

(Molaei et al., 2019)

Flies expressing HDAC1^JF01401 under the control of Scer\GAL4^fat exhibit significantly shorter survival time under starvation stress, as compared to controls.

(Nakajima et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

HDAC1^GL01005, Scer\GAL4^ey.PH is a suppressor | partially of abnormal size | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

HDAC1^GL01005, Scer\GAL4^ey.PH is a suppressor | partially of visible | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Phenotype Manifest In

Suppressor of

Statement

Reference

HDAC1^GL01005, Scer\GAL4^ey.PH is a suppressor | partially of eye phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36800

y¹ sc^* v¹ sev²¹; P{TRiP.GL01005}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

HDAC1^GL01005

(Nakajima et al., 2016)

Rpd3^GL01005

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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