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General Information
Symbol
Dmel\AkhUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lee
FlyBase ID
FBal0157367
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Akh, UAS-dAkh
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an Akh cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of AkhScer\UAS.cLa driven by Scer\GAL4Akh.PL significantly decreases survival under starvation conditions, compared to controls.

Mid-third instar larvae expressing AkhScer\UAS.cLa under the control of Scer\GAL4Act.PU exhibit moderately increased glucose levels.

Expression of AkhScer\UAS.cLa under the control of Scer\GAL4fat largely depletes lipid storage droplets and organismal fat stores.

Expression of AkhScer\UAS.cLa under the control of Scer\GAL4Akh.PL does not alter larval hemolymph trehalose levels. Expression of AkhScer\UAS.cLa under the control of Scer\GAL4r4 results in larval hemolymph trehalose levels that are about 34% above normal. In addition, hemolymph glycerol concentrations are significantly higher than normal, while the triglyceride content of the fat body is reduced.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference

AkhUAS.cLa, Scer\GAL4Akh.PL is a non-suppressor of long lived | nutrition conditional phenotype of AstA-R2GD339, Scer\GAL4Akh.PL

Phenotype Manifest In
NOT Suppressor of
Statement
Reference

Scer\GAL4fat/AkhUAS.cLa is a non-suppressor of lipid droplet phenotype of AkhR1

Additional Comments
Genetic Interactions
Statement
Reference

Expression of AkhScer\UAS.cLa under the control of Scer\GAL4fat has no effect on the increased organismal fat content and accumulation of lipid storage droplets seen in GRHR1 mutant flies.

Expression of AkhScer\UAS.cLa under the control of Scer\GAL4fat reduces the increased organismal fat content seen in bmm1 mutant flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Ectopic expression of AkhScer\UAS.cLa under the control of Scer\GAL4Act.PU in the Akh1 mutant background suppresses the increased survival rate of Akh1 adult flies under starvation: the survival rate of AkhScer\UAS.cLa expressing flies is significantly lower than in both Akh1 mutants and wild-type controls.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
AkhScer\UAS.cLa
AkhUAS.cLa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Lee
Secondary FlyBase IDs
    References (12)