FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AstA-R2GD339
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General Information
Symbol
Dmel\AstA-R2GD339
Species
D. melanogaster
Name
FlyBase ID
FBal0198607
Feature type
allele
Associated gene
Dmel\AstA-R2
Associated Insertion(s)
Carried in Construct
P{GD339}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD339}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD339
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Voßfeldt et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Knockdown of AstA-R2 by the expression of AstA-R2GD339 driven by Scer\GAL4Akh.PL or Scer\GAL4Ilp2.PR or Scer\GAL4GMR67E10 significantly increases survival under starvation conditions, compared to controls.

      (Hentze et al., 2015)

      Adults expressing AstA-R2GD339 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4pnr-MD237 may result in semi-lethality, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 30-40% or 40-50% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

      Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 50-60% or 70-80% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

      (Mummery-Widmer et al., 2009)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      AstA-R2GD339, Scer\GAL4Akh.PL has long lived | nutrition conditional phenotype, enhanceable by AkhKK113271, Scer\GAL4Akh.PL

      (Hentze et al., 2015)
      NOT suppressed by
      Statement
      Reference

      AstA-R2GD339, Scer\GAL4Akh.PL has long lived | nutrition conditional phenotype, non-suppressible by AkhUAS.cLa, Scer\GAL4Akh.PL

      (Hentze et al., 2015)
      Enhancer of
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of AkhScer\UAS.cLa does not affect the starvation resistance seen in flies with expression of AstA-R2GD339 driven by Scer\GAL4Akh.PL.

      Co-expression of AkhKK113271 and AstA-R2GD339 driven by Scer\GAL4Akh.PL significantly enhances starvation resistance (compared to starvation resistance in either Scer\GAL4Akh.PL>AkhKK113271 or Scer\GAL4Akh.PL>AstA-R2GD339 alone).

      (Hentze et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AR-2GD339
      AstA-R2GD339
      Name Synonyms
      Secondary FlyBase IDs
        References (8)