FlyBase Allele Report: Scer\GAL4[Akh.PL]

Drives expression at embryonic stage 14 in the corpus cardiacum primordium. Expression is stronger in later embryos and in first instar larvae. In third instar larvae, expression is observed in neuronal processes that innervate the prothoracic gland; these processes are not labeled in first instar larvae. In the adult corpus cardiacum, expression is observed in AKHergic neurons that project to the brain and to the crop.

(FlyBase Curators, 2017)

ScerGAL4^Akh.PL is expressed in various neurons that innervate the ring gland, but is not expressed in the glandular cells themselves.

(Mattaliano et al., 2007)

ScerGAL4^Akh.PL first drives expression at embryonic stage 14 in the corpus cardiacum primordium. ScerGAL4^Akh.PL-driven expression is stronger in later embryos and in first instar larvae. In third instar larvae, expression is observed in neuronal processes that innervate the prothoracic gland; these processes are not labeled in first instar larvae. In the adult corpus cardiacum, expression is observed in AKHergic neurons that project to the brain and to the crop.

(Lee and Park, 2004)

Marker for

Reflects expression of

Akh

(Mattaliano et al., 2007, Lee and Park, 2004)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate | larval stage, with ImpL2^HMC05809

(Ghosh et al., 2022)

abnormal feeding behavior, with Hsap\OPRM1^UAS.Tag:FLAG

(Sellami et al., 2010)

abnormal starvation stress response | adult stage, with Akh^KK113271

(Koyama et al., 2021, Yoshinari et al., 2021)

abnormal starvation stress response | adult stage, with AstC-R2^JF01960

(Kubrak et al., 2022)

abnormal starvation stress response | adult stage, with AstC-R2^UAS.KO.pCFD6, Spyo\Cas9^UAS.P2

(Kubrak et al., 2022)

abnormal starvation stress response | adult stage, with CapaR^{UAS.gRNAx4.pCFD6}, Spyo\Cas9^UAS.P2

(Koyama et al., 2021)

abnormal starvation stress response | adult stage, with NPFR^JF01959

(Yoshinari et al., 2021)

abnormal starvation stress response | adult stage, with NPFR^KK112704

(Yoshinari et al., 2021)

abnormal starvation stress response | adult stage | female, with Akh^KK113271

(Kubrak et al., 2022)

abnormal starvation stress response | adult stage | female, with AstC-R2^KK102954

(Kubrak et al., 2022)

decreased rate of feeding behavior | female, with Akh^KK113271

(Kubrak et al., 2022)

decreased rate of feeding behavior | female, with AstC-R2^KK102954

(Kubrak et al., 2022)

fertile, with rpr^UAS.cZa

(Lee and Park, 2004)

increased body weight | larval stage, with ImpL2^HMC05809

(Ghosh et al., 2022)

increased rate of feeding behavior | adult stage, with NPFR^JF01959

(Yoshinari et al., 2021)

increased sleep | adult stage | nutrition conditional, with AstC-R2^UAS.KO.pCFD6, Spyo\Cas9^UAS.P2

(Kubrak et al., 2022)

long lived | calorie restriction conditional, with Akh^KK113271

(Koyama et al., 2021)

long lived | nutrition conditional, with Akh^KK113271

(Hentze et al., 2015)

long lived | nutrition conditional, with AstA-R2^GD339

(Hentze et al., 2015)

short lived | calorie restriction conditional, with CapaR^{UAS.gRNAx4.pCFD6}, Spyo\Cas9^UAS.P2

(Koyama et al., 2021)

short lived | nutrition conditional, with Akh^UAS.cLa

(Hentze et al., 2015)

viable, with Cyp303a1^KK105532

(Wu et al., 2019)

viable, with nvd^RNAi.1.UAS

(Yoshiyama et al., 2006)

viable, with rpr^UAS.cZa

(Lee and Park, 2004)

Phenotype Manifest In

adult fat body, with CapaR^{UAS.gRNAx4.pCFD6}, Spyo\Cas9^UAS.P2

(Koyama et al., 2021)

lipid droplet | adult stage, with CapaR^{UAS.gRNAx4.pCFD6}, Spyo\Cas9^UAS.P2

(Koyama et al., 2021)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Akh^KK113271, Scer\GAL4^Akh.PL has long lived | nutrition conditional phenotype, enhanceable by AstA-R2^GD339, Scer\GAL4^Akh.PL

(Hentze et al., 2015)

AstA-R2^GD339, Scer\GAL4^Akh.PL has long lived | nutrition conditional phenotype, enhanceable by Akh^KK113271, Scer\GAL4^Akh.PL

(Hentze et al., 2015)

Suppressed by

Statement

Reference

AstC-R2^KK102954, Scer\GAL4^Akh.PL has abnormal starvation stress response | female | adult stage phenotype, suppressible by Akh^KK113271, Scer\GAL4^Akh.PL

(Kubrak et al., 2022)

CapaR^{UAS.gRNAx4.pCFD6}, Scer\GAL4^Akh.PL, Spyo\Cas9^UAS.P2 has abnormal starvation stress response | adult stage phenotype, suppressible by Akh^KK113271, Scer\GAL4^Akh.PL

(Koyama et al., 2021)

CapaR^{UAS.gRNAx4.pCFD6}, Scer\GAL4^Akh.PL, Spyo\Cas9^UAS.P2 has short lived | calorie restriction conditional phenotype, suppressible by Akh^KK113271, Scer\GAL4^Akh.PL

(Koyama et al., 2021)

NPFR^JF01959, Scer\GAL4^Akh.PL has abnormal starvation stress response | adult stage phenotype, suppressible by Akh^KK113271, Scer\GAL4^Akh.PL

(Yoshinari et al., 2021)

NOT suppressed by

Statement

Reference

Akh^KK113271, Scer\GAL4^Akh.PL has long lived | calorie restriction conditional phenotype, non-suppressible by CapaR^{UAS.gRNAx4.pCFD6}/Spyo\Cas9^UAS.P2, Scer\GAL4^Akh.PL

(Koyama et al., 2021)

Akh^KK113271, Scer\GAL4^Akh.PL has abnormal starvation stress response | adult stage phenotype, non-suppressible by CapaR^{UAS.gRNAx4.pCFD6}/Spyo\Cas9^UAS.P2, Scer\GAL4^Akh.PL

(Koyama et al., 2021)

AstA-R2^GD339, Scer\GAL4^Akh.PL has long lived | nutrition conditional phenotype, non-suppressible by Akh^UAS.cLa, Scer\GAL4^Akh.PL

(Hentze et al., 2015)

Enhancer of

Statement

Reference

AstA-R2^GD339, Scer\GAL4^Akh.PL is an enhancer of long lived | nutrition conditional phenotype of Akh^KK113271, Scer\GAL4^Akh.PL

(Hentze et al., 2015)

Akh^KK113271, Scer\GAL4^Akh.PL is an enhancer of long lived | nutrition conditional phenotype of AstA-R2^GD339, Scer\GAL4^Akh.PL

(Hentze et al., 2015)

Suppressor of

Statement

Reference

Akh^KK113271, Scer\GAL4^Akh.PL is a suppressor of abnormal starvation stress response | female | adult stage phenotype of AstC-R2^KK102954, Scer\GAL4^Akh.PL

(Kubrak et al., 2022)

Akh^KK113271, Scer\GAL4^Akh.PL is a suppressor of abnormal starvation stress response | adult stage phenotype of CapaR^{UAS.gRNAx4.pCFD6}, Scer\GAL4^Akh.PL, Spyo\Cas9^UAS.P2

(Koyama et al., 2021)

Akh^KK113271, Scer\GAL4^Akh.PL is a suppressor of short lived | calorie restriction conditional phenotype of CapaR^{UAS.gRNAx4.pCFD6}, Scer\GAL4^Akh.PL, Spyo\Cas9^UAS.P2

(Koyama et al., 2021)

Akh^KK113271, Scer\GAL4^Akh.PL is a suppressor of abnormal starvation stress response | adult stage phenotype of NPFR^JF01959, Scer\GAL4^Akh.PL

(Yoshinari et al., 2021)

NOT Suppressor of

Statement

Reference

CapaR^{UAS.gRNAx4.pCFD6}/Spyo\Cas9^UAS.P2, Scer\GAL4^Akh.PL is a non-suppressor of long lived | calorie restriction conditional phenotype of Akh^KK113271, Scer\GAL4^Akh.PL

(Koyama et al., 2021)

CapaR^{UAS.gRNAx4.pCFD6}/Spyo\Cas9^UAS.P2, Scer\GAL4^Akh.PL is a non-suppressor of abnormal starvation stress response | adult stage phenotype of Akh^KK113271, Scer\GAL4^Akh.PL

(Koyama et al., 2021)

Akh^UAS.cLa, Scer\GAL4^Akh.PL is a non-suppressor of long lived | nutrition conditional phenotype of AstA-R2^GD339, Scer\GAL4^Akh.PL

(Hentze et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^Akh.PL/CapaR^UAS.cKa rescues CapaR^{UAS.gRNAx4.pCFD6}

(Koyama et al., 2021)

NPFR^UAS.cYa/Scer\GAL4^Akh.PL rescues Df(3R)BSC464/NPFR^sk8

(Yoshinari et al., 2021)

Fails to rescue

Scer\GAL4^Akh.PL/Kdm5^UASp.cSa fails to rescue Kdm5¹⁴⁰

(Drelon et al., 2019)

ERR^UAS.cTa/Scer\GAL4^Akh.PL fails to rescue ERR²/ERR¹

(Tennessen et al., 2011)

Arc1^UAS.cMb/Scer\GAL4^Akh.PL fails to rescue Arc1^esm18

(Mattaliano et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

25684

y¹ w^*; P{Akh-gal4.L}3

25683

y¹ w^*; P{Akh-gal4.L}2/CyO, y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Scer\GAL4^Akh.PL

Name Synonyms

Adipokinetic hormone-like promoter construct of Lee

(Lee and Park, 2004)

Secondary FlyBase IDs

References (58)

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