FlyBase Allele Report: Dmel\Akh[1]

General Information

Symbol

Dmel\Akh¹

Species

D. melanogaster

Name

FlyBase ID

FBal0320779

Feature type

allele

Associated gene

Dmel\Akh

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

TALEN

Nature of the Allele

Allele class

Mutagen

TALEN

(Sajwan et al., 2015)

Progenitor genotype

Cytology

Description

3bp deletion resulting in the loss of the second amino acid residue (Leu) from the Akh protein.

(Sajwan et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response

(Zemanová et al., 2016)

abnormal starvation stress response | adult stage

(Saedi et al., 2024, Sajwan et al., 2015)

increased body size | adult stage

(Sajwan et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Akh¹/Akh¹ 5 day old males show significantly reduced mortality under starvation conditions compared to wild type. Akh¹/Akh¹ flies have similar mortality rates in response to paraquat toxicity (20mM) as wild type.

(Zemanová et al., 2016)

Akh¹ homozygotes are viable with no obvious morphological defects. The adult flies are slightly but significantly heavier than controls and their survival rate upon starvation is significantly increased compared to controls.

(Sajwan et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Akh¹ has abnormal starvation stress response | adult stage phenotype, enhanceable by mir-137^CR

(Saedi et al., 2024)

Akh¹ has abnormal starvation stress response | adult stage phenotype, enhanceable by mir-137^KO

(Saedi et al., 2024)

Suppressed by

Statement

Reference

Akh¹ has abnormal starvation stress response phenotype, suppressible by AdoR¹/AdoR¹

(Zemanová et al., 2016)

Enhancer of

Statement

Reference

Akh¹ is an enhancer of abnormal starvation stress response | adult stage | semidominant phenotype of mir-137^CR

(Saedi et al., 2024)

Akh¹ is an enhancer of abnormal starvation stress response | adult stage | semidominant phenotype of mir-137^KO

(Saedi et al., 2024)

Suppressor of

Statement

Reference

Akh¹/Akh¹ is a suppressor of abnormal starvation stress response phenotype of AdoR¹

(Zemanová et al., 2016)

Other

Statement

Reference

AdoR¹, Akh¹ has abnormal oxidative stress response phenotype

(Zemanová et al., 2016)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Akh¹/Akh¹;AdoR¹/AdoR¹ double mutants have similar mortality rates to wild type flies under starvation conditions. Akh¹/Akh¹;AdoR¹/AdoR¹ double mutants have significantly higher mortality rates than controls in response to 20mM paraquat (Akh¹/Akh¹ single mutants are similar to wild type and AdoR¹/AdoR¹ single mutants show resistance to paraquat).

(Zemanová et al., 2016)

Ectopic expression of Akh^Scer\UAS.cLa under the control of Scer\GAL4^Act.PU in the Akh¹ mutant background suppresses the increased survival rate of Akh¹ adult flies under starvation: the survival rate of Akh^Scer\UAS.cLa expressing flies is significantly lower than in both Akh¹ mutants and wild-type controls.

(Sajwan et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Akh¹ is partially rescued by Scer\GAL4^Act.PU/Akh^UAS.cLa

(Sajwan et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Akh¹

(Saedi et al., 2024, Zemanová et al., 2016, Sajwan et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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