FlyBase Allele Report: Dmel\mir-137[KO]

General Information

Symbol

Dmel\mir-137^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0301901

Feature type

allele

Associated gene

Dmel\mir-137

Associated Insertion(s)

TI{TI}mir-137^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2014)

Mutagen

ends-out gene targeting

(Chen et al., 2014)

FLPase

(Chen et al., 2014)

I-SceI

(Chen et al., 2014)

Progenitor genotype

Associated Insertion(s)

TI{TI}mir-137^KO

Cytology

Description

The mir-137 hairpin has been deleted. A w^+mW.hs marker which is flanked firstly by a pair of loxP sites and secondly (flanking the loxP sites) by a pair of inverted attP sites is present in place of the deleted sequence.

(Chen et al., 2014)

Allele components

Component

Use(s)

Also carries

attP

integrase target site

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye

(Padma et al., 2025)

germline cell | embryonic stage (with Df(2R)BSC888)

(Chen et al., 2014)

Detailed Description

Statement

Reference

mir-137^KO/Df(2R)BSC888 embryos show a significant increase in primordial germ cell number compared to controls.

3-5 day old homozygotes show reduced climbing ability in a negative geotaxis assay.

(Chen et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mir-137^KO has abnormal starvation stress response | adult stage | semidominant phenotype, enhanceable by Akh¹

(Saedi et al., 2024)

NOT Enhanced by

Statement

Reference

mir-137^KO has abnormal starvation stress response | adult stage | semidominant phenotype, non-enhanceable by Scer\GAL4^elav-C155/Akt^GD1361

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | adult stage | semidominant phenotype, non-enhanceable by Scer\GAL4^elav-C155/Pi3K92E^A2860C.UAS

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | adult stage | semidominant phenotype, non-enhanceable by Scer\GAL4^elav-C155/InR^K1409A.UAS

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | adult stage | semidominant phenotype, non-enhanceable by Scer\GAL4^elav-C155/InR^GD104

(Saedi et al., 2024)

Suppressed by

Statement

Reference

mir-137^KO/mir-137^CR has abnormal starvation stress response | adult stage phenotype, suppressible by Scer\GAL4^arm.PS/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO/mir-137^CR has increased body weight | adult stage phenotype, suppressible by Scer\GAL4^arm.PS/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO has increased body weight | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO has decreased rate of adult locomotory behavior phenotype, suppressible by Scer\GAL4^elav-C155/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | semidominant | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO/mir-137^CR has increased body weight | adult stage phenotype, suppressible | partially by Scer\GAL4^elav-C155/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO/mir-137^CR has abnormal starvation stress response | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO/mir-137^CR has decreased rate of adult locomotory behavior phenotype, suppressible by Scer\GAL4^elav-C155/Ptp61F^HMS00421

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | semidominant | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Ilp2^UAS.cBa

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | semidominant | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Ilp5^UAS.cUa

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | semidominant | adult stage phenotype, suppressible by Scer\GAL4^Ilp2.PR/Ilp2^UAS.cBa

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | semidominant | adult stage phenotype, suppressible by InR^A1325D.UAS/Scer\GAL4^InR.PU

(Saedi et al., 2024)

mir-137^KO has abnormal starvation stress response | semidominant | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Pi3K92E^UAS.Exel

(Saedi et al., 2024)

Enhancer of

Statement

Reference

mir-137^KO is an enhancer of abnormal starvation stress response | adult stage phenotype of Akh¹

(Saedi et al., 2024)

NOT Enhancer of

Statement

Reference

mir-137^KO is a non-enhancer of abnormal starvation stress response | adult stage phenotype of Akt^GD1361, Scer\GAL4^elav-C155

(Saedi et al., 2024)

mir-137^KO is a non-enhancer of abnormal starvation stress response | adult stage phenotype of Pi3K92E^A2860C.UAS, Scer\GAL4^elav-C155

(Saedi et al., 2024)

mir-137^KO is a non-enhancer of abnormal starvation stress response | adult stage phenotype of InR^K1409A.UAS, Scer\GAL4^elav-C155

(Saedi et al., 2024)

mir-137^KO is a non-enhancer of abnormal starvation stress response | adult stage phenotype of InR^GD104, Scer\GAL4^elav-C155

(Saedi et al., 2024)

Suppressor of

Statement

Reference

mir-137^KO is a suppressor | partially of abnormal starvation stress response | adult stage phenotype of InR^A1325D.UAS, Scer\GAL4^elav-C155

(Saedi et al., 2024)

mir-137^KO is a suppressor | partially of increased mortality phenotype of InR^A1325D.UAS, Scer\GAL4^elav-C155

(Saedi et al., 2024)

Other

Statement

Reference

Myc^JF01761, Scer\GAL4^ey.PH, mir-137^KO/mir-137[+] has decreased size | adult stage phenotype

(Padma et al., 2025)

Akt^UAS.ORF, Scer\GAL4^elav-C155, mir-137^KO has abnormal starvation stress response | adult stage phenotype

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^elav-C155, mir-137^KO has abnormal starvation stress response | adult stage phenotype

(Saedi et al., 2024)

Phenotype Manifest In

Other

Statement

Reference

Myc^JF01761, Scer\GAL4^ey.PH, mir-137^KO/mir-137[+] has eye phenotype

(Padma et al., 2025)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

mir-137^KO is partially rescued by Scer\GAL4^elav-C155/mir-137^UAS.cUa

(Saedi et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58893

w^*; TI{TI}mir-137^KO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

miR-137^KO

(Padma et al., 2025, Saedi et al., 2024)

mir-137^KO

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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