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General Information
Symbol
Dmel\Pi3K92EUAS.Exel
Species
D. melanogaster
Name
FlyBase ID
FBal0156075
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-PI3K, UAS-PI3K92E
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The coding region of wild type Pi3K92E (FBgn0015279) was cloned into P{Express-UAS}. Expression is governed by UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Pi3K92EUAS.Exel under the control of Scer\GAL4en-e16E leads to an increase in cell death in third instar larval wing discs.

Overexpression of Pi3K92EScer\UAS.Exel in the developing eye, under the control of Scer\GAL4GMR.PF, causes large, disorganised eyes.

Overexpression of Pi3K92EScer\UAS.Exel in the posterior compartment of the wing, under the control of Scer\GAL4e22c, results in an overgrowth phenotype in the wing.

Neuronal expression of Pi3K92EScer\UAS.Exel under the control of Scer\GAL4elav-C155 increases sensitivity to ethanol sedation.

Expression of Pi3K92EScer\UAS.Exel under the control of Scer\GAL4Bx-MS1096 results in a down-curled wing phenotype in 5.5% of flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Enhancer of
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Suppressed by
Enhancer of
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Pi3K92EScer\UAS.Exel does not suppress the reduction in trichome density seen in the wings of flies expressing trblScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4e16A.

Expression of Pi3K92EScer\UAS.Exel under the control of Scer\GAL4ppk.PG enhances the dendrite pruning defects seen in Mical15256 mutant ddaC neuron clones at 16 hours after puparium formation.

Depletion of Hdac3 in the eye, through expression of Hdac3dsRNA.Sym.Scer\UAS under the control of Scer\GAL4GMR.PF, strongly suppresses the overgrown, disorganised eye phenotype (with increased ommatidial size) found upon expression of Pi3K92EScer\UAS.Exel in the eye. These double-mutant flies exhibit a phenotype similar to Hdac3dsRNA.Sym.Scer\UAS single mutants.

Depletion of Hdac3 in the posterior compartment of the wing, through expression of Hdac3dsRNA.Sym.Scer\UAS under the control of Scer\GAL4e22c, strongly suppresses the overgrowth phenotype in the wing, upon expression of Pi3K92EScer\UAS.Exel.

Co-expression of His4K16A.Scer\UAS and Pi3K92EScer\UAS.Exel in the developing eye, under the control of Scer\GAL4GMR.PF results in an increase in eye size and the ommatidial overgrowth phenotype found upon expression of Pi3K92EScer\UAS.Exel alone.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Pi3K92EScer\UAS.Exel
Pi3K92EUAS.Exel
Name Synonyms
Secondary FlyBase IDs
    References (13)