FlyBase Allele Report: Dmel\Ptp61F[HMS00421]

General Information

Symbol

Dmel\Ptp61F^HMS00421

Species

D. melanogaster

Name

FlyBase ID

FBal0248182

Feature type

allele

Associated gene

Dmel\Ptp61F

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00421}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00421}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00421

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of intestinal cancer

CEA

(Liu et al., 2022)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of intestinal cancer

is ameliorated by ex^UASp.EGFP

(Liu et al., 2022)

is ameliorated by yki^GD11187

(Liu et al., 2022)

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^UAS.cEa

(Lee et al., 2020)

model of cancer

is ameliorated by Hsap\PTPN2^UAS.Tag:HA

(Liu et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ptp61F^HMS00421 driven by Scer\GAL4^nos.PU does not significantly affect germline stem cell number in testes.

(Tarayrah et al., 2015)

Females heterozygous for Ptp61F^HMS00421 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Ptp61F^HMS00421 males results in: 90% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of abnormal starvation stress response | semidominant | adult stage phenotype of mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of decreased rate of adult locomotory behavior phenotype of mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor | partially of increased body weight | adult stage phenotype of mir-137^KO/mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of abnormal starvation stress response | adult stage phenotype of mir-137^KO/mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of decreased rate of adult locomotory behavior phenotype of mir-137^KO/mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of increased body weight | adult stage phenotype of mir-137^KO

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of decreased rate of adult locomotory behavior phenotype of mir-137^KO

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of abnormal starvation stress response | semidominant | adult stage phenotype of mir-137^KO

(Saedi et al., 2024)

Scer\GAL4^arm.PS/Ptp61F^HMS00421 is a suppressor of abnormal starvation stress response | adult stage phenotype of mir-137^KO/mir-137^CR

(Saedi et al., 2024)

Ptp61F^HMS00421/Scer\GAL4^r4 is a suppressor of abnormal starvation stress response | adult stage phenotype of mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^arm.PS/Ptp61F^HMS00421 is a suppressor of increased body weight | adult stage phenotype of mir-137^KO/mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^elav-C155/Ptp61F^HMS00421 is a suppressor of increased body weight | adult stage phenotype of mir-137^CR

(Saedi et al., 2024)

Ptp61F^HMS00421, Scer\GAL4^repo.PU is a suppressor | partially of short lived phenotype of Hsap\TARDBP^UAS.cEa, Scer\GAL4^repo.PU

(Lee et al., 2020)

Ptp61F^HMS00421, Scer\GAL4^repo.PU is a suppressor | partially of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\TARDBP^UAS.cEa, Scer\GAL4^repo.PU

(Lee et al., 2020)

Ptp61F^HMS00421, Scer\GAL4^nanos.PU is a suppressor of decreased cell number phenotype of Kdm5^GL00612, Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

NOT Suppressor of

Statement

Reference

Ptp61F^HMS00421/Scer\GAL4^r4 is a non-suppressor of increased body weight | adult stage phenotype of mir-137^CR

(Saedi et al., 2024)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ptp61F^HMS00421, Scer\GAL4^repo.PU is a suppressor of NMJ bouton | third instar larval stage | decreased number phenotype of Hsap\TARDBP^UAS.cEa, Scer\GAL4^repo.PU

(Lee et al., 2020)

Ptp61F^HMS00421, Scer\GAL4^nanos.PU is a suppressor of male germline stem cell phenotype of Kdm5^GL00612, Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Ptp61F^HMS00421 suppresses the loss of germline stem cells in testes with lid^GL00612 driven by Scer\GAL4^nos.PU.

(Tarayrah et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

32426

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00421}attP2

NIG-Fly

HMS00421

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00421}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ptp61F^HMS00421

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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