The increase in the number of proliferating (EdU+) cells observed in the posterior midgut of adult flies upon expression of InRA1325D.Scer\UAS driven by Scer\GAL4esg-NP5130 (combined with Gal80[ts] for temporal control) is completely abolished by co-expression of Sam-SKK107709.
Larval fat body clones co-expressing Tl10b.UAS.cUa and InRA1325D.UAS under the control of Scer\GAL4Act5C.PP, however, do not show exhibit the nucleus sizes increases and decreases respectively observed upon single expressions of Akt1UAS.Tag:Myr(Unk) and Tl10b.UAS.cUa.
The ability of Scer\GAL4insc-Mz1407-driven expression of InRA1325D.Scer\UAS to induce central brain neuroblast reactivation in the absence of dietary amino acids is prevented by co-expression of ChroKK105370.
The increased cell-death phenotype of CskQ156Stop/CskQ156Stop somatic clones (induced specifically in the eye disc) expressing Ras85DV12.Scer\UAS under Scer\GAL4Act.PU is fully suppressed by co-expression of InRA1325D.Scer\UAS, resulting in tumor overgrowth of the eye disc in nearly all larvae. Majority of the larvae fail to pupariate, the ones that manage do so with a significant delay.
Expression of InRA1325D.Scer\UAS enhances the R8 photoreceptor phenotype seen when gogoScer\UAS.T1 is expressed under the control of Scer\GAL4GMR.PF, resulting in an increase in the size of the blob-like structures seen in the medulla M1 layer. Many of the R8 axons terminate before reaching their final destination, the M3 layer. A number of axons also stop in the medulla M1 layer.