UAS regulatory sequences drive expression of 100 pure repeats of a "protein-only" version of Zzzz\poly-GR using alternative codons to those found within the GGGGCC repeat.
FlyBase curator comment: "FTDALS1" is associated with human C9ORF72 dipeptide repeat proteins.
partially lethal - majority die, with Scer\GAL4GMR.PU
short lived | RU486 conditional, with Scer\GAL4elav.Switch.PO
eye, with Scer\GAL4GMR.PU
Expression of Zzzz\poly-GRPO-100.Scer\UAS using Scer\GAL4GMR.PU causes eye degeneration and increased lethality.
Expression of Zzzz\poly-GRPO-100.Scer\UAS in adult neurons using Scer\GAL4elav.Switch.PO (in combination with RU486 treatment) causes a substantial decrease in survival.